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Posted by Nootropics Depot on February 28, 2019
There are thousands of different herbs that get used by various traditional medicine systems and cultures, yet each of these cultures and traditional medicine systems have a few different herbs that they keep in very high regard. In traditional Chinese medicine, this herb is Panax ginseng, which is seen as being able to aid the body function better in almost every regard. It is seen as a true panacea. In a similar vein, Ashwagandha is one of the most widely discussed and used herbs in Ayurveda. It too is seen as a panacea that can help the body function better. In fact, in Ayurveda, Ashwagandha is one of various ‘Rasayana’ herbs, which loosely translates to ‘rejuvenator’. In more modern interpretations, Ashwagandha is often times classified as an adaptogen supplement. The term ‘adaptogen’ is a fairly modern interpretation of a concept that was developed more than 70 years ago by N.V. Lazarev, a Russian pharmacologist. In 1947 N.V. Lazarev was running various experiments with dibazol, a compound which acts as an arterial dilator. During these experiments he was starting to observe an effect he had never encountered before. It seemed that dibazol was non-specifically balancing biological processes within an organism while they were being exposed to adverse influences such as stress. He called this effect SNIR, which stands for "a state of nonspecifically increased resistance.
Following the initial dibazol experiments, many other SNIR compounds followed and were shown to allow individuals to better cope with mental and physical stress. The thing that made these SNIR compounds very unique, is that they seemed to give the body what it needed. This mechanism of action later led to SNIR compounds being referred to as ‘adaptogens’ as they are able to adapt to our bodies needs. Although the term ‘adaptogen’ was coined fairly recently, adaptogens have actually been in use for thousands of years. Ancient traditional medicine systems, such as ayuverdic medicine, were aware of these balancing effects for a very long time. Part of the reason why there is such a large emphasis on balancing and rejuvenation in traditional medicine systems is because adaptogens are abundantly present throughout nature. For example, besides ashwagandha, Nootropics Depot carries a plethora of other adaptogens such as:
These are natural substances and are highly regarded traditionally for their rejuvenating effects. In fact, all adaptogens are now classified as natural herbs and plants with synthetic molecules that have adaptogen-like effects being referred to as actoprotectors.
Now, with there being so many adaptogens, it is often times hard to choose which one to supplement with. Luckily, adaptogens have a wide range of effects. Some can be a little bit more energizing while others can be much more calming. What makes Ashwagandha unique, is that it is very calming and great for stress relief, while not causing much lethargy. This makes it one of the best adaptogens to keep a level head at all times, while making sure our bodies stay healthy and happy, even during times of enhanced stress.
Ashwagandha is a herb that belongs to the night shade family of plants. The nightshade family of plants is a very interesting one and includes a lot of vegetables that make up large parts of many diets. Notable nightshade members are potatoes, tomatoes, chili peppers, goji berries and even tobacco! Another name for the nightshade family is Solanaceae. This is where Ashwagandha gets its Latin name from; Withania somnifera. Ashwagandha is a short perennial shrub, with a large root system that develops small deep orange fruits. The fruits resemble a small cherry and the leaves look frosty due to the many tiny hairs that are on them. This one of the reasons why Ashwagandha is also referred to as ‘winter cherry’. Traditionally, the Ashwagandha root is used, however new research has found high concentrations of key components in the leaves too. Various manufacturers have taken notice of this. One of the most notable being Natreon who produce a specialized extract of Ashwagandha called Sensoril. Sensoril is made from the leaves of Ashwagandha, giving it a unique chemical composition, which produces noticeable calming effects.
The Ashwagandha Plant
What compounds are in Ashwagandha?
As mentioned above, Ashwagandha supplements can be made from various parts of the plant. The motivation behind using different parts of the plant, comes down to which compounds manufacturers are interested in extracting. As mentioned earlier, Sensoril is made from the leaves of Ashwagandha, which yields very high levels of glycowithanolides. Glycowithanolides however, only make up a small portion of the chemical composition of Ashwagandha. Below is an extensive list of the main active constituents in Ashwagandha:
Together, all of these compounds create significant health-boosting, stress-lowering and cognition boosting effects. However, there are a few key players that produce the majority of the effects and these are usually referred to as the withanolides and glycowithanolides. Due to this, you will often see products that are standardized to withanolides such as our basic Ashwagandha offering which is standardized to 4-5% withanolides. That being said, even though the other compounds present in Ashwagandha aren’t being standardized for, they still exist in Ashwagandha extracts and help boost the effectiveness of withanolides. As a very general rule of thumb, extracts that are standardized for the glycowithanolides are going to be very calming because they have significant effects on our GABA system. Extracts that more generally standardize for withanolides are going to be more balanced and more adaptogenic. Keep this is mind when picking a Ashwagandha supplement. Below are some brief description of each Ashwagandha supplement we carry:
As mentioned earlier, Ashwagandha root has been used for centuries. So, what makes it so attractive and why has it been used for so long? Traditionally, before we could determine via scientific studies what effects Ashwagandha had on the body, Ashwagandha was already being used for many of the same applications as it currently is. It was mainly used in India, in Ayurvedic medicine as a rejuvenator, relieving the body from fatigue and stress. Other potential Ashwagandha benefits include:
As mentioned earlier, traditional preparation of Ashwagandha root involved the use of milk. This is due to the fact that Ashwagandha contains both water and fat-soluble compounds. Milk, being a mixture of both water and fat, allows for efficient extraction and absorption of the bioactive molecules contained within Ashwagandha. This allows for the highest amount of Ashwagandha benefits.
One of the biggest limiting factors to our overall cognitive health are the physiological effects of elevated stress. Besides feeling "stressed", which can manifest itself as feelings of uncontrollable energy contrasted by paradoxical mental exhaustion, there is a lot going on in our bodies and brains when we are exposed to abnormal levels of stress. One of the main biochemical responses to stress is a rapid elevation in the levels of various stress hormones called corticosteroids. One of the most well known corticosteroids is cortisol which is produced by our adrenal cortex. Cortisol plays a role in a large variety of processes in our bodies, which under normal condition are very beneficial to our overall health. In fact, cortisol becomes elevated at certain points in the day. For example, cortisol is highly elevated in the mornings. Under normal circumstances, this will help us feel alert and motivated while also ramping up our metabolism. Cortisol levels drop later in the day, which will decrease alertness and make it easier to relax and go to sleep. Under elevated stress, these normal fluctuations in cortisol levels (which are collectively referred to as the diurnal cortisol curve) can become dis-regulated. This can manifest itself in a variety of different ways, such as a flat plateau, where cortisol levels increase in the morning and remain elevated. It can also completely flip around, resulting in low morning cortisol levels and high evening cortisol levels. In a real world interpretation, this may cause excessive stimulation during the day, excessive tiredness in the morning or excessive stimulation at night. Bare in mind, these are just the effects of disregulated cortisol that we can perceive. There is a whole lot more going on under the hood.
Elevated cortisol levels may have a very detrimental effect on the cells contained in a part of our brains called the hippocampus. It is thought that a large portion of memory processing, especially the acquisition stage of memory, occurs in the hippocampus. Thus, it is no surprise that elevated cortisol levels in response to stress, can hamper memory function. Furthermore, elevated corticosteroid levels in response to stress can also significantly dampen our natural immune response. A combination of hampered cognitive and immune function can be very detrimental to productivity and can be a big blow to our general quality of life. So how do we minimize the physiological impact of stress in such a high stress world? One of the best options is identifying your main sources of stress and attempting to manage them on a behavioral level. However, sometimes this is not possible and we need a little extra help. Luckily, Ashwagandha has some powerful stress management benefits.
Withanolide A, one of the major bioactive molecules in Ashwagandha, has been reported to normalize elevated corticosteroid levels during elevated stress. Through this mechanism of action, Ashwagandha can help protect us from the potential negative effects of elevated cortisol levels. This mechanism of action, can also help support our memory, help promote overall cognitive function and help promote immune system strength.
The withanolides have also been shown to promote overall brain health. They can achieve this by providing robust neuroprotective effects through normalizing elevated glutamate levels. Glutamate is an important excitatory neurotransmitter. In normal levels, glutamate helps us form and store memories. However, in abnormally high levels, it can cause damage to our brain cells. By normalizing glutamate levels, Ashwagandha can help promote overall brain health.
The glycowithanolides in contrast to the withanolides are not as stress reducing. Rather, they appear to be very neuroprotective and calming. Various studies have shown that glycowithanolides can help promote relaxation and a positive mood. One of the mechanisms by which glycowithanolides appear to achieve this is by normalizing the levels of tribulin. Levels of tribulin increase when stress levels are elevated and may cause feelings of restlessness and a gloomy mood. Via reducing tribulin levels, Ashwagandha may help regulate these feelings of restlessness and instead may promote relaxation and a positive mood. Ashwagandha benefits also appear to extend to the GABA system. Ashwagandha does this by enhancing signaling through the GABA A receptor, which is one of the primary inhibitory receptors in the brain. By enhancing signaling through the GABA A receptor, Ashwagandha may be able to promote significant feelings of relaxation, which may even translate to improved sleep quality!
Withanolide A has been shown to help normalize our immune system during periods of stress. It does this through a few mechanisms. The first is normalizing elevated corticosteroid levels which will result in a general normalizing effect on our immune system. However, Withanolide A goes a step further and appears to increases the expression of the Th1 cytokines, interferon gamma, and interleukin-2 whilst decreasing the Th2 cytokine, interleukin-4. These compounds are all important regulators of our immune system, and the specific shift that withanolide A is able to induce may help promote stronger immune function.
As we mentioned earlier, stress can have a major impact on sleep if it starts to shift our diurnal cortisol curve to elevated cortisol levels at night. This will make it hard for us to unwind from a busy day, which makes it very hard to get into a relaxed enough state to fall asleep. This is often characterized by racing thoughts at bed time, which in the worst-case scenario may keep us tossing and turning all night, resulting in exhaustion the following day. Since Ashwagandha can normalize cortisol levels, this alone can help improve our sleep quality.
Ashwagandha sleep benefits also extend to the GABA system. Sleep is a very complex phenomenon, but we have come to the understanding now that GABA plays a critical role in the initial stages of sleep. GABA is referred to as an inhibitory neurotransmitter. Metaphorically speaking, think of GABA as the brake in your car. GABA gives us the ability to slow down our brain, allowing it to enter a state of lowered activity which will help facilitate sleep.
As we mentioned earlier in this article, there are various different forms of ashwagandha on the market. At nootropics depot, we carry three different forms, Sensoril, KSM-66, and a basic Ashwagandha extract. We described how each of these extracts works, based on the bioactive compounds in each, but we haven’t touched on the practical applications yet. The question remains: Which Ashwagandha supplement should I take to maximize ashwagandha benefits for myself? Below is our answer, albeit somewhat general, through blind tests around the office we have formed the following opinions about the extracts that we carry:
Still not certain which the Ashwagandha supplement is best for you? Try out our Ashwagandha Extract powder sample pack.
There is not one universal Ashwagandha dosage due to the different levels of standardization. However, in general, an Ashwagandha powder extract dosage is going to be around 300-500 mg. This general Ashwagandha dosage falls in line with the various extracts we carry. For example, the Ashwagandha dosage for KSM-66 is 300 mg and the Ashwagandha dosage for our basic Ashwagandha powder extract is 500 mg. The Ashwagandha dosage for Sensoril is a little bit of an outlier, at 125 mg, but this is due to the fact that it is such a potent extract.
How to take Ashwagandha is a question we often times receive. For the most convenient method, we recommend using our Ashwagandha capsules. However, if you are set on Ashwagandha powder, then there are a few methods that can be used. If you are currently following a keto diet, it is easy to incorporate Ashwagandha in various keto recipes. One very popular keto recipe is bulletproof coffee. In this keto recipe, black coffee is mixed with grass fed butter and MCT oil.This keto recipe is a perfect vehicle for our selection of Ashwagandha powder. As mentioned earlier, Ashwagandha bioactives are both water and fat soluble which is why traditionally Ashwagandha root is consumed with milk. Bulletproof coffee mimics this somewhat by combining fats and water. Thus, adding one of our Ashwagandha powders to this keto recipe, would result in optimized absorption. We would recommend using KSM-66 Ashwagandha for this method of supplementation due to its mild and milky taste. A keto diet can actually elevate cortisol levels, and thus, Ashwagandha powder would be a fantastic addition to various beverag-based keto recipes such as Bulletproof coffee.
Other mild tasting Ashwagandha powders, such as Sensoril (mild taste due to low dosage), can be used to make Ashwagandha tea. To make this Sensoril-based Ashwagandha tea, we would recommend brewing some chamomile tea, adding Sensoril powder to it, and drinking it before bed. This Ashwagandha tea recipe can be enhanced by the addition of some milk and honey, which combined with the Sensoril and chamomile, will make for a very peaceful night of sleep!
When to take Ashwagandha is another question we frequently receive. Our general advice for Ashwagandha supplements is to take them in the morning. We suggest this due to the fact that a vast majority of stress is experienced during the day. For Ashwagandha supplements such as Sensoril, we would recommend taking these about 1-2 hours before bed if the goal is to enhance sleep quality.
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