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Along with L-ornithine and L-arginine, L-citrulline makes one of three main amino acids in the urea cycle. Citrulline forms as a product of ornithine when combined with carbamoyl phosphate during the urea cycle, which is your body’s natural process of removing ammonia from its system. Ammonia naturally forms in your body as a waste product of digesting protein. Citrulline can also form as a product when your body converts arginine into nitric oxide.
Malate, also known as malic acid, in nature is known as the compound responsible for giving many fruits their sour flavor. Malate is also often used as a preservative, but when bound to citrulline, malate can provide greater stability in the body, streamlining its effectiveness. When taken as a nootropic, L citrulline offers a wide range of potential benefits to support your health.
When taking citrulline malate, your body metabolizes it into pure citrulline. Your body then converts it into arginine, another important amino acid. Arginine is then converted into nitric oxide, which leads to further production of citrulline. Nitric oxide is a vasodilator and plays a key role in your health.
L-citrulline has been shown to gradually increase levels of arginine in plasma over a longer, steadier period of time. Initially, L-arginine was a popular choice, but studies have found that it took less citrulline malate to increase levels of plasma arginine than actual arginine. A German study found that a 3 gram dose of citrulline malate produced the same benefits as 6 grams of arginine.
Citrulline malate has become popular among athletes and those looking to potentially improve their cardiovascular health and performance in sports. L-citrulline benefits are rooted in this increased supply of nitric oxide. Researchers from the University of Southern California suggest that nitric oxide is a vasodilator, meaning that it helps to open your blood vessels. This allows for improved blood flow to your organs.
Studies reported that subjects given citrulline while made to perform intense exercise had less lactate and ammonia in their system. These are waste compounds created during exercise that lead to muscle fatigue. Another study on cyclists found that those cyclists who took citrulline malate had more efficient use of amino acids in their muscle tissue. Citrulline malate has also been shown to accelerate the neutralization of ammonia in your muscles. Ammonia can decrease pH levels in your muscles, causing your muscles to become more acidic, leading quickly to fatigue. These studies all suggest that citrulline malate may help to improve your endurance during aerobic and anaerobic exercise while simultaneously reducing muscle fatigue.
Preliminary studies with weightlifters found that those who took citrulline malate had a greater number of repetitions, suggesting that it may potentially help to increase power outputs during exercise. These weightlifters also showed reduced muscle soreness after their high volume repetitions.
Small clinical studies have shown that citrulline malate may support cardiovascular health. In one study, a group of healthy male subjects who took citrulline were found to have improved arterial function as their arterial walls were made to be less stiff. Other studies suggest that citrulline may regulate blood pressure.
As a dietary supplement, take 3000mg of L-Citrulline DL-Malate 2:1 Powder once daily.
Nootropics Depot offers 125g or 250g jars of L-Citrulline DL-Malate 2:1 Powder. Nootropics Depot's L-Citrulline DL-Malate powder has been lab-tested and verified for both product purity and identity.
To learn more, read the L-citrulline DL-malate 2:1 reviews and experiences below.
Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.
First time trying this product. Use it for pre-workout and feel the difference. JCoffee on 5th Aug 2017
I take 3 grams of this before jiu jitsu and I can see an immediate improvement in performance. I dont get tired as quickly and my grips stay stronger. Would recommend! Becky on 15th Jul 2017
Of all the NO2 boosters I've tried; Arginine, agmatine, etc, this one seems to work the best. It also has the added benefit of flushing out or buffering ammonia which provides a nice mood boost and more energy. I practice the Wim Hof Method and I really love this stuff along with the breathing and ice baths. Anthony Voskuhl Jr on 9th Jun 2017