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Polygala tenuifolia, commonly referred to as Yuan Zhi, Chinese senega and thinleaf milkwort, is a root that is commonly used in traditional Chinese medicine, where it is known as yuan zhi. In its traditional use, Polygala tenuifolia reportedly had protective effects on the brain. Current studies suggest that Polygala tenuifolia may act as a powerful nootropic.
Research on rodent subjects suggest that Polygala tenuifolia’s main mechanism of action and effect involve interactions with NMDA (N-methyl-D-aspartic acid) and NMDA receptors. NMDA is an amino acid derivative that is similar in function to glutamate. While small amounts of NMDA may be normal or may even prove beneficial, it is generally categorized as an excitotoxin, meaning it can cause over-excitation of nerve cells by flooding receptors, potentially resulting in cell damage and death.
NMDA may also increase the release of glutamate, an amino acid and neurotransmitter that is involved in nearly all forms of normal brain functions. Glutamate acts as mediator of excitatory signals in the brain, but a flood of glutamate or a sensitivity to the neurotransmitter can cause cells to become overexcited, leading to glutamate-induced excitotoxicity.
Many of the potential Polygala tenuifolia benefits that users may experience are related to its effects on NMDA receptors. Studies show that the extract may act as an NMDA receptor antagonist, which may result in improved cognition, memory, and learning abilities. Research indicates that Polygala tenuifolia may act as a neuroprotective agent by preventing excitotoxicity induced by NMDA and glutamate. In some studies, Polygala tenuifolia was found to improve memory and memory loss caused by aging.
Preliminary studies also show that Polygala tenuifolia may provide mood support, which may be related to its blocking of NMDA receptors. Inhibiting NMDA or blocking its receptors has been found to result in calming effects. Other studies also indicate that the extract may cause feelings of relaxation.
Research suggests that Polygala tenuifolia extract may have adaptogen-like properties. Adaptogens refer to compounds that may help you adapt to physical and emotional stress to potentially prevent negative effects. Polygala tenuiflia has been shown to reduce cortisol levels. Cortisol is the main stress hormone that is often responsible for many of the negative effects associated with chronic stress.
Studies have found that Polygala tenuifolia extract may also increase nerve growth factor and brain-derived neurotrophic factor. Nerve growth factor is a protein-like molecule responsible for creating new neurons while repairing and maintaining existing neurons. It also plays a role in repairing the myelin sheath around the nerves, allowing for the proper firing of signals and communication between nerves. Tests on animals show that reducing the production of nerve growth factor in the brain damages the ability to create new connections while impairing memory access and retention. By potentially increasing nerve growth factor, Polygala tenuifolia may not only promote brain health, but also improve abilities related to memory and information processing.
Brain-derived neurotrophic factor (or BDNF) is similar to nerve growth factor. It is involved in learning, higher thinking, and long-term memory and encourages cell growth and regeneration. However, brain-derived neurotrophic factor also has a role in neuroplasticity, which is the brain’s way of changing and adjusting to new experiences or changes in the environment, essentially allowing you to learn, process information, and reorganize thoughts.
As a dietary supplement, take one 100mg Polygala tenuifolia 20:1 Extract capsule three times daily.
This extract is a 20:1 Dual Water/Ethanol Extract.
For more information, read the Polygala tenuifolia reviews below.
Product contains one (1) 90ct. or 180ct. jar of Polygala tenuifolia 20:1 Extract 100mg capsules (Yuan Zhi).
You may also be interested in Polygala tenuifolia 20:1 extract powder.
*Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.
No effect whatsoever after repeated use on daily basis. The other customers who wrote 5star reviews probably had a placebo effect.
ND Admin: You wrote this same review on TeaCrine as well. Perhaps you are experiencing the nocebo effect. We've had so many people email us about how great their effects were from polygala, it's very surprising. It's one of the most effective natural extracts we carry. I'm sorry you didn't get the effects you were looking for, but calling placebo on everything you don't react well to is not scientific. Unknown on 13th Jan 2018
I love this herb. It stabilizes my moods, It helps me focus, gives me smooth energy, and even better sleep at night. It's an all around boost, mentally and emotionally. It takes time to build up in the system. I did not feel a thing for the first three days, and then day 4, boom! I had to cut it to one capsule a day for a week or so. then I increased to two. After three weeks I was ready for the recommended three a day. I suggest they change the bottle directions to say one capsule one to three times a day. This is nature's alternative to anti depressants. And I bet it would do wonders for those with ADHD symptoms. I'm surprised it isn't more well known. I feel like I have found a game changer. Scott Grace on 8th Jul 2017
...when used over a long period 3x/day. Also massively aids spacial awareness, too. srubek on 18th Jun 2017