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What is the difference between Tianeptine Sodium and Tianeptine Sulfate?
The most common form of tianeptine is the sodium salt. Tianeptine sodium is very hygroscopic, and absorbs water very easily from the atmosphere. This not only makes handling it difficult, but means that its pharmacokinetics lean towards rapid absorption in the stomach and GI tract. This is because compounds taken orally need to dissolve before they can be absorbed. Tianeptine sulfate differs from tianeptine sodium by replacing the sodium with a sulfate group. This creates a new salt that is much less hygroscopic than the sodium version. This makes it easier to handle, as it does not absorb moisture from the air like tianeptine sodium does. On top of that, tianeptine sulfate is much more dependent on pH for its solubility, It requires a neutral pH to be soluble. This means that the low pH of the stomach prevents it from absorbing there. It stays insoluble till it reaches the neutral pH of the small intestine. This not only slows the onset, but slows the absorption of the compound, making the effects smoother and longer-lasting than the sodium salt.
Tianeptine sulfate (CAS: 1224690-84-9) has a molar mass of 1008.004 g/mol and a molecular formula of C42H56Cl2N4O14S3.
Tianeptine Sodium (CAS 30123-17-2) has a molar mass of 458.9 g/mol and a molecular formula of C21H24ClN2O4S • Na