About Quercetin Phytosome Quercefit Capsules

Quercetin Phytosome features the clinically studied Quercefit, a phytosome-enhanced form of quercetin that boosts bioavailability nearly 20-fold compared to standard quercetin. This flavonoid supports immune function through its zinc ionophore activity, helps maintain healthy histamine levels, and supports exercise performance and recovery.

Our Quercetin Phytosome Story

During the 2020 health crisis, quercetin gained widespread attention for its zinc ionophore properties and immune support benefits. However, standard quercetin suffers from poor bioavailability due to its water solubility limitations. While increasing dosage was one solution, we wanted to tackle this challenge with advanced formulation technology rather than simply throwing more milligrams at the problem.

Phytosome technology embeds quercetin particles within phospholipid spheres to dramatically improve absorption. This approach addresses quercetin's partition coefficient issues by creating smaller particle sizes while surrounding the quercetin with phospholipids that enhance its solubility profile. The result is Quercefit, a scientifically validated quercetin phytosome that delivers superior bioavailability, making each dose more effective at supporting your health goals.

Benefits

• Supports Immune Function: Quercetin acts as a zinc ionophore, shuttling zinc directly into cells where it can support cellular function and enhance immune function throughout the body.
• Supports Healthy Inflammatory Response: Supports healthy histamine levels by helping regulate histamine release from mast cells, supporting the body's healthy inflammatory response and supporting sleep quality.
• Supports Healthy Oxidative Response: Provides antioxidant support while supporting NAD+ pathways by helping modulate CD38, an enzyme that affects this crucial cellular energy molecule.
• Supports Exercise Performance: Supports exercise performance through AMPK activation, with studies showing triathlon athletes experienced faster sprint times and quicker recovery when supplemented with quercetin phytosome.

The phytosome delivery system embeds quercetin particles in phospholipids, overcoming quercetin's natural water solubility issues and poor partition coefficient. This formulation increases bioavailability nearly 20-fold compared to standard quercetin, ensuring your body can effectively utilize this flavonoid's wide-ranging benefits.

Quality and Standardization

• Quercefit Phytosome Technology: Our quercetin is formulated using the clinically studied Quercefit phytosome delivery system, which embeds quercetin particles within a phospholipid matrix to overcome its natural water solubility limitations.
• Bioavailability Enhancement: The phytosome formulation achieves nearly 20-fold greater bioavailability compared to standard quercetin by reducing particle size and improving the compound's partition coefficient (LogP) for enhanced absorption.
• Sophora Japonica Source: We source our quercetin from the flower buds of Sophora japonica, where this flavonoid naturally concentrates in its highest potency form for optimal benefit.
• Third-Party Testing: Each batch undergoes rigorous purity and identity verification through our third-party labs to ensure consistent quality and potency in every capsule.
• Standardized Dosing: Each capsule provides precisely 250mg of Quercefit phytosome, delivering a relevant dose based on clinical research while maintaining excellent tolerability profiles.

Mechanism of Action

• Zinc Ionophore Activity: Quercetin acts as a cellular transport facilitator for zinc ions, helping shuttle this essential mineral directly across cell membranes where it can support cellular function and immune cell activity.
• Histamine Activity Support: The flavonoid supports healthy histamine levels through cellular membrane activity, providing natural support for healthy inflammatory responses.
• AMPK Pathway Support: Quercetin supports AMP-activated protein kinase (AMPK), a master metabolic regulator that supports cellular energy production and contributes to exercise endurance and recovery.
• CD38 Enzyme Activity: By supporting healthy CD38 activity, an enzyme that affects NAD+, quercetin helps support cellular longevity pathways and mitochondrial energy metabolism throughout the body.
• Phospholipid Delivery System: The phytosome technology encapsulates quercetin within phospholipids that naturally integrate with cell membranes, dramatically improving absorption and bioavailability compared to standard quercetin formulations.

Overview of the Science

Quercetin phytosome represents a significant advancement in flavonoid supplementation, addressing the fundamental bioavailability challenges that have historically limited quercetin's potential [1]. The phytosome delivery system embeds quercetin molecules within a phospholipid matrix, creating a lipid-compatible structure that dramatically enhances absorption across cellular membranes. This technology overcomes quercetin's poor water solubility and low partition coefficient, which typically prevent effective uptake in the gastrointestinal tract. Clinical research demonstrates that the phytosome formulation increases quercetin bioavailability by nearly 20-fold compared to standard quercetin extract, making previously inaccessible doses available through practical supplementation.

Beyond improved bioavailability, quercetin phytosome demonstrates unique effects on cellular metabolism and longevity pathways that distinguish it from other flavonoids. The compound activates AMPK (adenosine monophosphate-activated protein kinase), a master metabolic regulator that enhances cellular energy efficiency and promotes mitochondrial biogenesis. Additionally, quercetin supports NAD+ levels by inhibiting CD38, an enzyme responsible for degrading NAD+, thereby supporting cellular energy production and DNA repair mechanisms. These metabolic effects complement quercetin's well-established support for antioxidant activity, creating a multifaceted approach to cellular health that extends beyond traditional support for a healthy inflammatory response.

[1] Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y. Front Immunol. 2016;7:373.

Ingredients

Quercefit® Quercetin Phytosome®:

• Sophora japonica extract (flower)
• 34% Quercetin standardization
• 250mg per serving
• Phytosome® delivery technology for enhanced absorption

The Phytosome® technology combines quercetin with sunflower lecithin to create a phospholipid complex that dramatically improves bioavailability compared to standard quercetin extracts. This patented delivery system allows the quercetin to pass through the intestinal barrier more efficiently, resulting in significantly higher plasma levels and better tissue distribution. The 34% standardization ensures consistent potency, while the phytosome formulation means you get more quercetin where your body needs it most.