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Arginine Alpha-Ketoglutarate (AAKG) is a 2:1 mixture of the amino acid arginine and alpha-ketoglutarate.
Alpha-ketoglutarate (AKG) is the deaminated carbon skeleton (missing the amino group) of the amino acids glutamic acid (aka glutamate) and glutamine. Alpha-ketoglutarate is also an intermediate in the Kreb's cycle, a set of metabolic processes involved in energy (ATP) production from fats and carbohydrates, as well as amino acid metabolism. As such, AKG is an important metabolic link between cellular energy production and protein metabolism.
In states of high protein intake or simply during normal protein turnover, AKG receives the amino (nitrogen containing) groups from amino acids, forming glutamate, which then contributes to the urea cycle (where urea is produced and eventually lost in the urine). AKG can also be used in transamination reactions to generate arginine (as well as proline and histidine). Mixing AKG with arginine would therefore favor less deamination of arginine, preserving it and prolonging its effects.
In disease states of impaired protein metabolism such as dialysis, supplementing with AKG by itself positively affects amino acid handling. AKG also improves intestinal health (perhaps by assisting in glutamine metabolism, which fuels the immune system of the gut, improves immune function during physiological trauma (e.g., burns) and positively affects protein turnover in a malnourished or hypocaloric (negative caloric balance) state.
For more information see the AAKG Wiki.
Product contains one (1) 125g or 250g Jar of AAKG 2:1 Powder.
Attention: All chemical compounds have risks. Please consult your physician, and understand the available research, before consumption. This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.