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Agmatine sulfate is a biogenic amine stored in the brain’s neurons and is released when these neurons are activated. It is derived from the amino acid L-arginine during decarboxylation reactions, which involves the removal of a carboxyl group. Agmatine sulfate is sometimes considered as a neurotransmitter or neuromodulator. From various studies and clinical trials, agmatine sulfate shows promise as a nootropic that may improve general cognitive health.
The main mode of action that has been studied in agmatine sulfate involves regulation and inhibition of NMDA (N-methyl-D-aspartate acid) and glutamate receptors. NMDA is a an amino acid derivative with a similar role and structure as glutamate. Small amounts of NMDA may be necessary to normal cognitive function and health, but the compound is more often considered an excitotoxin. This refers to compounds that may overexcite nerve cells by flooding receptors. This over-activation and excitation may lead to cell damage or even cell death.
NMDA and glutamate are closely tied. Glutamate is a neurotransmitter and your body’s main mediator of excitatory signals in the brain. NMDA may cause an increased amount of glutamate. While glutamate is involved in nearly every cognitive function, sensitivities to glutamate or sudden floods of the neurotransmitter causes glutamate-induced excitotoxicity.
The potential agmatine sulfate benefits you may receive are similar to those of arginine, though agmatine sulfate may be more powerful. Research suggests that agmatine sulfate may act as a powerful antioxidant. Antioxidants are designed to neutralize free radicals, a natural product of cellular oxidation. Free radicals can damage and mutate cells, leading to a variety of potential disorders.
Research indicates that agmatine sulfate is a neuroprotective agent. Along with its potential status as an antioxidant, agmatine sulfate may prevent over-activity and excitotxicity induced by excess NMDA and glutamate. Glutamate has also been found to be one of the main neurotransmitters involved in memory function and neuroplasticity. Neuroplasticity refers to your brain’s ability to change and adjust based on new experiences, emotions, and environments. This is essentially your brain’s ability to learn new things and reorganize information. Through agmatine sulfate, you may potentially improve your brain’s learning abilities and memory functions.
Agmatine sulfate may also present benefits for athletes. Studies show that agmatine sulfate may improve the body’s response to insulin, which may then contribute to leaner, harder, and larger muscles.
Agmatine sulfate has also been observed in some studies to regulate nitric oxide production. Nitric oxide is a molecule naturally produced in the body that plays a role in the transmission of signals between nerve cells in the body. Aging can reduce nitric oxide levels in the body and reduce its overall efficiency. Nitric oxide plays a role in a variety of internal processes, including reducing inflammation, regulating blood pressure, and assisting the immune system. In terms of cognitive processes, nitric oxide has been observed to help memory and behavior.
As a dietary supplement, take two 250mg Agmatine Sulfate capsules daily.
For more information, read the agmatine reviews below.
Nootropics Depot offers 60ct. or 120ct. jars of high quality Agmatine Sulfate capsules. Nootropics Depot's Agmatine Sulfate has been lab tested for product purity and identity.
You may also be interested in agmatine sulfate powder.
*Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.
I read about the use of agmatine to reverse tolerance formed from taking opioid pain medications for a long period of time. I have chronic back pain (10 out of 10 on a pain scale without medication) and must take low to moderate dose opioid so I can function in simple everyday tasks. I first ordered agmatine from another online seller, and was disappointed with the results. Nootropics Depot.com offers a different quality of Agmatine Sulfate, and the results have been much more promising. I take this supplement once every 12 hours and it seems to increase the efficacy of my pain medications by 10 to 20%. It has successfully reversed much of the tolerance I have built up to the opioids. I am thrilled that this supplement is working, as it is preventing me from having to escalate the dosages of my pain medication. I will be sharing this information with my colleagues, friends, and the medical professionals treating me. Thank you nootropicsdepot.com for offering such a wonderful quality of supplements. Unknown on 10th Mar 2018
This is the best supplement available period. It does a lot of wonderful things, and Nootropics Depot always delivers the best highest purity supplements with super quick shipping!
I find that Agmatine does many really good things for me:
1. Feeling of calm or peace for about 2-4 hours, not as strong as Phenibut but it's noticeable and present. It's more of a calm peace than a "chill" mode.
2. Reduction of tolerance to almost everything
3. Potentiates almost everything
4. Seems to treat my depression and anxiety
5. Increased "pumps" at the gym - just feels like a larger blood rush to the muscles. Bralexon on 1st Dec 2017
My intended use was for athletic performance. It definitely increases blood flow to muscles in response to training, similar to arginine alpha ketoglutarate. The decrease in pain threshold was odd, but not unbearable. I would recommend only taking on workout days about 30 minutes to 1 hour prior to the start of exercise.
I take other nootropics so it would be hard to isolate any mental benefits from this alone. Unknown on 3rd Sep 2017
Seems to be more effective than other nootropics.
Agmatine sulf is not promoted much but produces better results than some promoted nootropics on areas of attention & mood.
Needs to be taken about 2-3 weeks to notice effects.
Apparantly it is highly bioavailable so its absorbed well.
Unknown on 16th Jul 2017
Nootropics Depot provides great quality products and I trust them for that. From my experience it is great for pumps in the gym anywhere from 500-1000mg. Also, if you use sparingly, gives a great feeling of overall well being in the same dosage. Supposedly lowers tolerance to certain herbs or drugs, but does not work as well as abstinence for some time in that regard. nick on 11th May 2017