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Agmatine Sulfate Powder

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$20.99 - $33.99


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Some EU countries consider agmatine a novel food ingredient, and may not allow it through customs. Please look up your country's specific regulations before purchasing.
Agmatine Sulfate
125g or 250g
500 Servings or 1000 Servings
As a dietary supplement, take 250mg of Agmatine sulfate 1-2 times daily.
Store in a cool and dry place. Keep away from direct sunlight and heat.
Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.
Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases. These statements have not been evaluated by the Food and Drug Administration.
This product does not include a scoop. Transfer scoops are not an accurate form of measurement. A milligram scale is needed to accurately measure this product.

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ATTENTION EUROPEAN CUSTOMERS: Some EU countries consider agmatine a novel food ingredient, and may not allow it through customs. Please look up your country's specific regulations before purchasing.

What is Agmatine Sulfate Powder?

Agmatine sulfate is a biogenic compound derived from L-arginine, a common amino acid involved in the synthesis of proteins. When L-arginine undergoes decarboxylation, a process that results in the removal of a carboxylic acid group, it becomes agmatine sulfate. This compound is stored in the neurons of the brain and released when those neurons are activated. The process of creating and storing Agmatine sulfate sets it apart from its amino acid counterpart. Agmatine sulfate is considered a neurotransmitter or neuromodulator which could explain some of the Agmatine sulfate nootropic effects some people experience. As a nootropic, agmatine sulfate offers a wide range of potential benefits to your brain health and general fitness.

Agmatine Sulfate Benefits and Uses

    • May help support positive emotional outlook
    • May help promote restful sleep
    • May help support immune system function
    • May help promote overall strength and endurance
    • May help support digestive health
    • May help promote cognitive function

Agmatine Sulfate Bodybuilding and Nootropic use

Agmatine sulfate benefits may impact a wide range of organs and systems to potentially improve overall health. The interaction between Agmatine sulfate with nitric oxide and NMDA receptors have been shown to support various elements of cognitive function and overall health. In particular, these findings focused primarily on memory and learning abilities.

Studies on Agmatine sulfate have also shown Agmatine sulfate’s ability to promote healthy levels of oxidation. Part of this ability may come from Agmatine’s ability to limit glutamate activity. High glutamate activity can potentially cause over-excitation in the brain, leading to something known as excitotoxicity. Excitotoxicity leads to degradation of nerve cells as a result of receptors being overactivated.

As far as how this translates to Agmatine sulfate nootropic effects, Agmatine appears to interact with several neurotransmitter systems and pathways. Agmatine appears to interact pretty strongly with glutamate receptors and pathways in particular. Studies have actually shown that Agmatine levels rise in some regions in the brain when learning something. Agmatine even appears to have a significant role in memory formation in these areas. So, taking an agmatine supplement may help promote memory formation events which may as a whole increase cognitive function focused on memory and learning.

Agmatine has built itself a reputation in the bodybuilding community for its ability to create huge muscle pumps through its Nitric oxide regulation. Nitric oxide is a compound naturally produced in your body that plays a role in cell signaling and communication throughout your entire system. Anecdotally, this enhanced connection also may promote one’s sense recognition and support feelings of well being. Agmatine sulfate is even used as an ingredient in various pre-workouts and “pump” supplements. In fact, it’s quite common to pair a pre-workout with agmatine sulfate and some athletes swear by the agmatine sulfate bodybuilding benefits. 

As if boosting Nitric oxide levels weren’t enough, Agmatine sulfate also appears to support blood flow by acting as a calcium antagonist. Studies have found that this mechanism of action may help soothe and widen blood vessels which may help support overall cardiovascular function. What’s even better, is that Agmatine may help produce lean muscle mass and may even help enhance muscle definition. This makes Agmatine sulfate one of the best muscle pump supplements out there!

How Agmatine Sulfate May Promote Cognitive Function

Agmatine sulfate also appears to interact with NMDA glutamate receptors. Once these receptors are activated, they allow positively charged ions to flow through cell membranes. NMDA receptors are also one of the key glutamate receptors involved in regulating memory functions and synaptic plasticity. Synaptic plasticity is important for the ability of signals between nerves to strengthen or weaken over time. A healthy level of synaptic plasticity means signals are more effectively communicated between neurons.

How to take Agmatine Sulfate and Agmatine Sulfate Dosage

As a dietary supplement, take 250mg of Agmatine sulfate 1-2 times daily. 

Agmatine Sulfate Reviews

To learn more, read the Agmatine sulfate reviews and experiences below.

Where to Buy Agmatine Sulfate Powder?

Nootropics Depot offers 125g or 250g jars of high quality Agmatine sulfate powder. Nootropics Depot's Agmatine sulfate has been lab-tested and verified for both product purity and identity.

You may also like Agmatine sulfate capsules

Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.

28 Reviews

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  • Brent - 23rd Mar 2022

    Agmatine Sulfate powder

    Works well for neuropathic pain and sleep.

  • Haldor Issente - 8th Mar 2022

    Agmatine sulfate

    Economical in the 250 gmail size. A potentiator for other substances. A pure product. Quite satisfied.

28 Reviews

  • Brent - 23rd Mar 2022

    Agmatine Sulfate powder

    Works well for neuropathic pain and sleep.

  • Haldor Issente - 8th Mar 2022

    Agmatine sulfate

    Economical in the 250 gmail size. A potentiator for other substances. A pure product. Quite satisfied.

  • Unknown - 8th Jan 2022

    Very Nice

    I will repurchase

  • Unknown - 4th Jan 2022


    So far this will remain on the top of my stack for everyday use.

  • Unknown - 3rd Jan 2022

    Grade A+

    Wonderful compound right here guys. This stuff is the real deal and I rank it at the top of the list.

  • Unknown - 2nd Jan 2022


    Taking this to get off a 4 year kratom use and it’s working flawlessly. I was taking kratom just to escape the withdrawals. Highly suggest to cut way back on ur kratom dose with this stuff like more than half. I’m on day 5 and I have cut my dose down to 4 grams 4 times a day to 1 gram 3 times a day. Also take magnesium to eliminate my restless leg.

  • blair darby - 18th Nov 2021

    Nice touch

    Are use this in combination with polygala Which adds a very nice touch, great clean energy

  • Rob Haskell - 19th Jun 2021

    subtle? yeah right.

    I found that this increased my bloodflow. There could possibly be some issues regarding both tolerance and overdosing, but not every workout product was a hit for me. I think you really have to find your sweet spot. I could be off but for me its probably around 300mg, but you have to sort of dose in a "triangle" shape throughout your on-week, in my experience. Lighter at first, then respond to the tolerance, then respect the buildup. It seems to build up short-term. I get nauseous if I overdo it. Anyways Im convinced that this one was a successful hit and if you buy anything else and also not this for working out then youre a whole fool. Start here. And for that, 5 full stars. Im reordering as we speak.

  • Kim V - 19th Oct 2020

    Surprise! It worked for me

    I've tried so many things. My main issues are 1) debilitating anxiousness that presents itself much different. It just makes me unable to do tasks, but no panic attacks, sweats, etc. Just extreme procrastination as I get a deep aversion/fear of tasks. Overnight, this helped that. I was able to do a task I'd avoided for 3 weeks. 2) Daily sinus blockage from a dust mite allergy. This made me able to breathe. 3) Mood - I just feel better. I have a whole closet of things I've tried & this one is best. Ashwagandha wasn't reliable, rhodiola helped but then caused the side effect of depression.

  • B. Alexander - 16th Oct 2020

    Levels me out.

    The one amino I incorporate most. Definitely calms me down. I tend to operate with a frantic, anxious, high strung energy. This doesn't knock me on my ass, but helps me operate on an even keel. I assume this effect is to do with Nitric oxide levels in the brain being lowered. I take 250mg in morning, and took 250mg at night at first, but I believe it was disrupting my sleep a bit, so I found that second dose on an empty stomach before dinner/early evening was the best. Great product.

  • donatelo - 6th Mar 2020

    Good mood and sleep

    That was unexpected but agmatine improves my mood and makes my sleep deeper. It feels like a mild psychedelic in a way. This is now a part of my base stack.

  • Jason - 25th Feb 2019

    Varied uses and effects

    relieve a small amount of anxiousness. it also bulked my muscles up to near the size they were when I was heavy into bodybuilding, without me having to exercise at all. Must be a muscle memory effect. Also, my appetite went out of control. It also helped my mother with her anxiousness more than me. It helped her with pain management to a mild degree.

  • Unknown - 16th Jan 2019

    Very subtle

    This substance has glowing reviews, but I haven't got any benefit. It's hard to tell if it really does something.

  • Mario - 1st Oct 2018


    I'm very satisfied with your brand and business ... I take agmatine about 750mg once and it looks like l arginine, for a more comprehensive answer I need more time and full usage.

  • Unknown - 27th Aug 2018

    Great Service and Quick shipping

    Highly recommended ++++++

  • Unknown - 20th Jul 2018

    great product

    Good quality product. Works well to maintain tolerances to other substances. By itself, it brings you more into the moment, which helps with concentration.

  • citrus - 15th Jul 2018

    amazing batch

    They say it has an effect when combined with MJ. That's probably why I don't notice it as much now: I don't have any MJ in my system. It also synergizes with lots of other things as well. I think people who are prescribed stims should take this at night. Like 250mg of it. It prevents tolerance/excitotoxicity and causes the brain tissues to create more neurotransmitters. I think it does a lot to help prevent adrenal exhaustion from stims. However if you take it during the day it's not a very good combination because you will be less productive and no amount of coffee will able to undo that.

  • TERESA - 5th Apr 2018

    if you want to stay awake all night

    Hi I am very new to nootropics and I am really still Experimenting with these . I have not found the right thing yet . I felt like agmatine Did help me to go to sleep a couple nights. I took 750 mg. I have also been taking phenylpiracetam and adrafinil and noopept along with choline The Choline I purchased at the health food store. Sometimes it makes me feel like I’m actually tired from taking it so maybe I just don’t know what I’m doing but I think they are probably very good products and I’m going to keep Trying.

  • Scott H., LVN - 4th Apr 2018

    Wish I had tried this sooner.

    Purchased Agmatine as a supplement to potentially increase vasodilation, but found that it was having other effects within two weeks of of starting a one gram b.i.d. regimen: °Greatly improved sleep architecture. °Mild to moderate stress support °Mild to moderate pain support °A very welcome mild cardiovascular effect All in all an awesome product that will always be present in my supplemental regimen. Thank You. Scott H., LVN

  • Trevor - 2nd Feb 2018

    smooth powder

    Great stacker with other nootropics. This one didn't make feel nauseous but rather more clarity of my surroundings.

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