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Alpha-GPC, also known as choline alfoscerate and alpha-glycerylphosphorylcholine, is a choline-containing compound found naturally in the brain as well as in small amounts in foods like meat, fish, eggs, and dairy.Alpha-GPC is also a natural phospholipid and precursor to the creation of phosphatidylcholine in the brain.
Studies and evidence show that alpha-GPC is considered one of the most efficient sources of choline, a fat-soluble member of the B vitamin complex. This indicates that alpha-GPC may effectively increase concentrations of choline. As a nootropic, it may present brain health properties.
Alpha-GPC is reported to have cognitive and growth-hormone enhancing properties. While there are no randomized, double-blind, placebo-controlled clinical trials showing this is true in healthy adults, anecdotal evidence and some research on rodents shows possibility.
Many potential alpha-GPC uses focus on its state as a precursor to acetylcholine, a neurotransmitter that helps the brain send signals to nerves throughout the body. Acetylcholine has been shown to play an important role in memory formation, concentration, logical reasoning, and learning. Studies have also found that acetylcholine may provide neuroprotective benefits, thereby limiting neurological deterioration caused by aging. Some preliminary studies on elderly participants suggest that alpha-GPC may reduce cognitive decline. Some studies may even suggest that alpha-GPC may work to repair cells that have been damaged.
Other studies indicate that alpha-GPC may support greater synaptic plasticity. This is essentially your brain’s method of adaptation and changing to new information, controlling how your neurons communicate with one another, which results in the process of creating and recalling memories. This may translate to improved retrieval and retention of information. According to research, alpha-GPC may enhance your overall learning capacity and problem solving abilities.
Alpha-GPC breaks down into components that have been found to effectively repair and maintain the membranes of your cells and brain. These membranes, or cell walls, form the foundation that allows your neurons to function and communicate with one another. Research indicates that alpha-GPC may boost the fluidity and stability of these membranes, resulting in improved cognition.
Furthermore, research has found that alpha-GPC may increase production of human growth hormone in the brain. Known as somatropin and somatotropin, human growth hormone is a single chain polypeptide containing 191 amino acids. Growth hormone produced and stored in the pituitary gland. In studies, this hormone has been found to encourage cell reproduction, growth, and regeneration. Research indicates that growth hormone may also have a positive effect by increasing natural metabolic rate, making alpha-GPC a popular nootropic among athletes. One early study suggested that alpha-GPC may enhance power output and improve overall athletic performance, but further study is required.
Research in rats indicates that alpha-GPC may also increase levels of serotonin and dopamine. This may result in feelings of calm and relaxation, potentially reducing negative effects of stress.
For typical use in enhancing athletic and cognitive performance, Alpha-GPC 99% Powder is recommended in one or two doses of 300 mg/day for a total of 300-600mg/day. Start with a smaller dose and find what works best for you. Always discuss the addition of any nootropics compounds with your primary care physician or another trusted health care professional.
We offer a naturally derived, non-GMO alpha-GPC product manufactured with organic ingredients. Alpha-GPC is also GRAS-affirmed by the FDA, meaning it is Generally Recognized As Safe.
Our Alpha-GPC 99% Powder is a nearly pure product for those who desire full potency, but we also offer Alpha-GPC 50% Powder for those concerned with alpha-GPC’s sensitive hydroscopic nature.
A Note on Hydroscopy
Alpha-GPC is a hydroscopic compound, which means it draws in moisture from the air around it, physically changing it from a powder to a gel-like substance when not stored properly. While this hydroscopic effect doesn’t necessarily mean the product has degraded, it is a sign of improper storage. Storing your Alpha-GPC in airtight containers (think vacuum seal) is helpful. While we take steps to ensure this does not happen to your product, should Alpha-GPC 99% arrive with clumps, simply break them up prior to use. Nootropics Depot offers both a 30g and 60g jar.
Why don’t we sell an Alpha-GPC 100% Powder? Alpha-GPC with a purity of greater than 99% will undergo hydroscopy very quickly as soon as it meets the air.
Always discuss the addition of nootropics and supplements with your doctor or another trusted healthcare professional, and stay informed about how a product might affect you--everyone is different.
*Attention: Before consumption, please consult your physician and understand the available research. This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.
Get insight about customers’ experiences by reading our Alpha-GPC reviews below.
I've tried this product from different companies and found this company to have the best quality; I am on my second order. This product gives me mental clarity and I've noticed it's been helping me shed some weight. Unknown on 5th Feb 2017
great product. will buy again. Unknown on 11th Jan 2017
Sans doute un classique des nootropiques, efficaces, au long-terme les effets sont juste incroyable, six mois après prise quotidienne d'alpha-GPC je peut me concentrer des heures et j'ai meilleure mémoire qu'avant, avant je ne tenait pas ma concentration plus de 30 minutes.
Aucun effets indésirable, adapter à tous. Unknown on 9th Nov 2016
Tastes great and saves me from Noopept everytime. Thanks Kermit on 29th Sep 2016
Alpha GPC 99% is one of my favorite compounds. When Nootropics Depot stopped carrying it, I was very sad. Sure it clumps more easily than the 50%, but I can deal with that. I am very happy to have a great source of 99% GPC again! Alvin Tan on 26th May 2016
This product did nothing for me. Unknown on 11th May 2016
First off, this product is very potent. It's the most effective alpha GPC I have tried from any vendor, and I have tried a lot. However, 99% alpha GPC is very hydroscopic, and clumps up super easily. Nootropics Depot puts in silica and oxygen absorbing packs, which really does help. It does not become an unusable gel like others.However, it still clumps very fast. I find the extra potency of the 99% to be worth it, but many might be surprised. Keep that thing sealed as best you can. If you do not want to deal with the extra hassle, the 50% is probably better for you. RobS on 16th Apr 2016
I am very grateful that NootropicsDepot.com is selling this product again. A couple years ago when I discovered Alpha-GPC 99% Powder at the old Nootropics Depot store I discovered that I could dissolve 30gm in 120ml (2oz) distilled water with 15gm Calcium Pantothenate and the solution easily remained dissolved. I used 1ml eyedropper to dispense this super choline solution in 2 to 4 ml doses. This solution worked better with my nootropic and neural health stacks than any other choline products. After the old Nootropics Depot disappeared a couple years ago, I was forced to find other vendors of pure Alpha-GPC. I discovered that when I made super Alpha-GPC solution using other vendor products that black stuff started growing in the solution even though I always keep it refrigerated. Now that I’m using NootropicsDepot.com Alpha-GPC 99% Powder again the solution remains clear to the last drop. I use 4ml of this solution every morning combined with 200mg Uridine Monophosphate powder and 200mg Dicaffeine Malate and high EPA/DHA fish oil, and also later in the day with racetams or Centrophenoxine. Thanks for bringing this product back! Unknown on 7th Apr 2016
Where I live is mostly dry. So I have no problems with the 99% version of Alpha-GPC clumping. I much prefer to have the pure powder without fillers. Alpha-GPC works better for me than CDP too. Steve on 13th Feb 2016