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Appearing naturally in a bright yellow color, berberine is an alkaloid compound and ammonium salt that is extracted from a variety of plants in the berberis genus, along with goldenseal (Hydrastis canadensis) and the Chinese goldthread (Coptis chinensis). All of these plants have commonly been used in Ayurvedic medicine and traditional Chinese medicine as anti-microbial agents.
Ingested orally, berberine generally has low bioavailability, which is why it is often paired with coconut oil. Coconut oil contains sodium caprate, a fatty acid that increases the effectiveness and absorption rate of berberine. Taken as a nootropic, berberine offers a variety of potential benefits to physical health and cognition.
Research on berberine points to AMPK modulation as one of the supplement’s main mechanisms of action. AMPK, or adenosine monophosphate kinase, is an enzyme that helps cells maintain their energy and is responsible for regulating nutrients within cells.
Increasing AMPK simultaneously increases the amount of glucose that is taken into fat cells, reducing glucose levels in blood. Furthermore, increased AMPK in the liver potentially inhibits cholesterol and triglycerides. This coincides with increased HDL (the “good” cholesterol) and reduced LDL (the “bad” cholesterol).
Berberine benefits both physical health and mental faculties. Early studies suggest that berberine may inhibit telomerase, a protein associated with the life cycle and proliferation of cells. By inhibiting telomerase, berberine may potentially prolong life and improve longevity. As a telomerase inhibitor, berberine may help prevent side effects of chemotherapy and work in tandem with cancer treatments to boost effectiveness.
Berberine may also support healthy stress levels. A study on mice found that berberine increased levels of dopamine, norepinephrine, and serotonin in the brain. Each of these neurotransmitters is associated with mood and feelings of happiness.
Another study with rats showed that berberine may protect the heart from damage. Along with inhibiting bad cholesterol, berberine was shown to prevent oxidative stress and significantly reduce blood pressure. This all suggests that berberine can improve heart health and protect the heart from sustaining damage from environmental stressors. Furthermore, berberine, through its AMPK amplification, can inhibit the synthesis of lower triglyceride levels and lipids. This can help those trying to lose weight.
As a dietary supplement, take 500mg of Berberine three times daily, preferably after a meal.
To gain more insight, read the Berberine reviews and experiences below.
Nootropics Depot offers 30g or 60g jars of high quality Berberine HCL Powder. Nootropics Depot's Berberine HCL has been lab-tested and verified for both product purity and identity.
*Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.
Warning: This product is extremely bitter and not readily soluble in water. The bitter flavor, which is much like bile, will linger for a very long time. In addition to this, the powder, when it comes into contact with fabrics or skin, will stain neon yellow. Handle with caution.