null Skip to main content
See Dietary Information
100% Vegan Lactose Free Gluten Free GMO Free
See Dietary Information
100% Vegan Lactose Free Gluten Free GMO Free

Berberine HCL Powder

(7 Reviews) Write a Review

Order within to have your order ship today.

Your order will be shipped tomorrow

label-lactose-free:
true
label-gluten-free:
true
label-gmo-free:
true
label-vegan:
true
label-vegetarian:
true
page-fact-checked:
false
Dietary Restrictions:
Lactose Free
Dietary Restrictions:
Gluten Free
Dietary Restrictions:
Non-GMO
Dietary Restrictions:
Vegan
Dietary Restrictions:
Vegetarian
Type:
Powders
disable-paypal:
false

Shop with confidence

FREE 2-3 Day Shipping

FREE 2-3 Day Shipping

Get free same-day shipping on US orders over $50 and international orders over $200.
Click here for more info

Same Day Shipping

Same Day Shipping

when placed Mon. - Friday by 4pm, or Sat. by 12pm AZ MST

Buy Berberine HCL Powder

What is Berberine?

Berberine is an alkaloid compound and ammonium salt that is found in various plants in the berberis genus. Berberine has a distinct bright yellow color and was widely used in traditional practices as a dye for various textiles. Berberine has an extensive history in Ayurveda, being used for promoting immune system function. Plants like Goldenseal (Hydrastis canadensis) and Chinese goldthread (Coptis chinensis) are natural sources of Berberine and have been used in Traditional Chinese practices and Ayurvedic practices. 

Berberine actually has low bioavailability when consumed orally. This is why some people pair coconut oil with Berberine. Coconut oil contains sodium caprate, which is a fatty acid that increases the effectiveness and absorption rate of Berberine. When taken as a nootropic, Berberine carries various potential benefits to cognitive function and physical health.*

Berberine Benefits and Uses

    • May help support optimal cellular function*
    • May help promote metabolic function*
    • May help support balanced inflammation levels*
    • May help promote feelings of well being*
    • May help support cognitive function*

How Does Berberine Work?

Berberine may benefit both physical health and mental faculties. Early studies suggest that berberine may regulate telomerase, a protein associated with the life cycle and proliferation of cells. Yet recent Berberine research leads toward AMPK modulation as one of Berberine’s primary mechanisms of action. AMPK, also known as Adenosine monophosphate kinase, is an enzyme that helps support cellular energy and has a role regulating cellular nutrients within cells. AMPK activation increases the uptake and breakdown of glucose through glycolysis. What also makes Berberine so interesting is that it may also slow down glucose production through gluconeogenesis. Some research finds that this may help promote optimal body composition and may help support exercise performance. Interestingly enough, this activity may play a role in the brain as well. Studies have shown that gluconeogenesis may help promote cognitive function. 

Although it may be a more indirect effect on cognition, research finds that Berberine benefits to cognition might also be directly attributed to Berberine’s ability to activate sigma-1 receptors. Activation at these receptors raises BDNF levels and helps optimize NMDA activity. Research on BDNF activity found that decreased levels of BDNF may lead to low mood and diminished cognitive function, thus supporting evidence that Berberine may help promote overall cognitive function and positive mood. What also makes Berberine’s effects even more interesting is that BDNF and NMDA activity is also highly correlated to memory creation. Further research has also found that Berberine may help promote acetylcholine levels by regulating acetylcholinesterase, the enzyme that breaks down acetylcholine. By blocking acetylcholinesterase, Berberine may help promote higher acetylcholine levels in the brain. This in combination with AMPK modulation and sigma-1 receptor activation makes Berberine a great option for those looking for a well rounded and all natural nootropic!

AMPK activation also speeds up the breakdown of fatty acids through fatty acid oxidation. As an added bonus, AMPK activation has dual effects as it may also regulate fatty acid production by regulating fatty acid synthesis. Berberine AMPK activation suggests that there may be Berberine benefits on weight loss. However, research finds that taking a Berberine supplement alone will not promote significant weight loss compared to pairing a Berberine supplement with a healthy diet and exercise routine.*

Berberine Dosage

As a dietary supplement, take 500mg of Berberine three times daily, preferably 20 minutes before a meal.

Berberine Reviews 

To gain more insight, see the Berberine reviews and experiences below. 

Where to Buy Berberine

Nootropics Depot offers 30g or 60g jars of high quality Berberine HCL Powder. Nootropics Depot's Berberine HCL has been lab-tested and verified for both product purity and identity.

You may also like Berberine HCL + Silymarin Tablets

 *Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Warning: This product is extremely bitter and not readily soluble in water. The bitter flavor, which is much like bile, will linger for a very long time. In addition to this, the powder, when it comes into contact with fabrics or skin, will stain neon yellow. Handle with caution.

Reviews

  • 5
    great product

    Posted by Anonymous on 27th Nov 2020

    I like taking it when fasted. It gives me mental clarity, focus and it makes it easier to go without food. The taste is terrible, so swallow quickly.

  • 5
    Panacea

    Posted by B. Alexander on 16th Oct 2020

    AMPK activator, Mood booster, Microbiome gatekeeper, blood sugar regulation, I could go on. Just look at that colour, taste that bitter goodness. We were meant to have our taste receptors engage with herbs like this. It's such a well rounded product, thrilled to have such a high quality version of it.

  • 5
    Excellent

    Posted by Donatelo on 14th Aug 2020

    I have been taking berberine for three months and like it a lot so far. The most noticeable effect for me is willpower: I feel much less compelled by addictive behavior, so I end up doing more productive things. It reminds me a lot of NAC in that sense. It also seems to reduce my appetite and improve my gut flora.

  • 4
    Berberine HCL

    Posted by joe on 26th Jun 2020

    Warning: Berberine does make some ill to their stomach (vomiting) enough to cause dehydration. Start with extremely low dosage and titrate up. Everything I have purchased from Nootropics Depot has been very high quality.

  • 5
    Incredible supplement for mood

    Posted by Mow Levise on 5th Jun 2020

    I've shared this with a few people and three of them so far have bought there own berberine from how much they liked it! Noticeable mood boost and a noticeable improvement in gym performance!

  • 5
    noticed one thing

    Posted by Unknown on 26th Oct 2018

    I've read that Berberine can potentially help with weight loss. I noticed that my appetite was more manageable throughout the day. I ate half my regular breakfast, didn't need to eat the moment I got in from work and did not snack after dinner. I took it in the morning and afternoon. I was less food obsessed overall. I'm going to keep taking it...see if I can drop these last few pounds.

  • 5
    Awesome product

    Posted by Cristian on 15th Jun 2018

    The boost in energy is very noticiable. Mental clarity is also increased, plus all the health benefits it has makes berberine one of the best products available in nootropicsdepot. It Does not taste like candy, but it worth the value

Trust Through Transparency

Your health matters, which is why we only use the best 3rd party ISO accreddited labs and cGMP certified and FDA registered facilities right here in the USA

Learn more

Frequently Bought Together

Please choose options for all selected products

  • Choose Options
*Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.