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Palmitoylethanolamide, or PEA, is a substance that is produced naturally within the body but was also isolated from egg yolk, soy lecithin, and peanut meal in 1954. Endogenously, this fatty acid amide binds to a receptor in the cell nucleus known as the peroxisome proliferator-activated receptor. It plays an important biological role within cells in response to inflammation. Palmitoylethanolamide appears to be produced in the body on-demand in areas of inflammation. It is also isolated from natural sources and made into Palmitoylethanolamide Capsules.
Research over the past several decades is leading to a greater understanding of the compound and its efficacy in improving conditions marked by inflammation and nerve pain.
Although it is produced in our bodies, supplementation with naturally derived Palmitoylethanolamide may further help the body in response to pain and inflammation. Research and clinical use in Italy, Spain, the Netherlands, and Germany suggests that Palmitoylethanolamide may support a variety of pain states.
Palmitoylethanolamide benefits are due in part to its ability to inhibit microglial and mast cells, two types of cells involved in inflammatory, immune, and pain response. As more research is conducted this compound could prove to be useful in helping to manage pain-related conditions.
View the Palmitoylethanolamide (PEA) Wikipedia to learn more about its benefits and uses.
Product includes one (1) 60ct. or 180ct. jar of Palmitoylethanolamide (PEA) Capsules.
*Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.
Get more insight by reading Palmitoylethanolamide reviews below.
No pain relief or any difference at all. Could be too soon to tell as have been taking less than a month. Going to keep going and pray it helps. shannon on 26th Aug 2017
It may take up to 8 weeks for the full Pain relieving effects of Palmitoylethanolamide to be noted. It's nice to know I found a good, reliable, fairly price place to purchase in Nootropicsdepote.com. I will continue to order from them in the future. Denise Bogan on 1st Nov 2016
Due to sharing many common receptor chains/pathways with CBD, I've found this to be a pretty good adjunct to CBD therapy. It makes me need less, as long as I stick to my 600mg x 3/day (I cap them myself, at this higher dose, since I purchased it in powder form and it fit comfortably into a size 00 capsule when tampered effectively in a capsule machine). Good for neuralgia, and neuropathic pain (numbness, tingling, shooting pain, sciatic pain). I wish it had a little more "oomph" to it, but I suppose thats the trade-off when side effects are minimal (only thing ever experienced was a tolerable feeling of heaviness in my stomach, and not always). 8/10 would recommend if you're looking to expand upon your neuropathic pain regimen. srubek on 30th Oct 2016
After over 15 years on opiates due to Lyme disease (fibromyalgia and arthritis) I decided they just weren't helping anymore. I didn't want to take more opiates, so my doctor suggested I try a combination of PEA and Low Dose Naldroxone. After over a month on the combination all I can say is that it's really working. At least as good pain control as on very strong opiates. I know that the PEA is a key component as I started it several weeks before the LDN. I'm NOT a doctor, just a long suffering patient, but if you have any auto immune issues or pain issues please speak your doctor about adding PEA and/or LDN to your regimen. Valerie Williams on 29th Oct 2016