About Cycloastragenol 10% Capsules

Cycloastragenol 10% Capsules deliver one of the most bioavailable telomerase activators available in supplement form. This triterpenoid compound is standardized to 10% cycloastragenol from Astragalus membranaceus root, providing superior absorption compared to its glycoside counterpart astragaloside IV. By bypassing the deglycosylation process that occurs with astragaloside IV, cycloastragenol supports longevity through direct telomere preservation while promoting enhanced energy levels and cellular health.

Our Cycloastragenol Story

We identified a significant gap in the telomerase activation market: most available compounds were either unstable peptides requiring complex storage and administration, or glycosides like astragaloside IV with poor bioavailability. Astragaloside IV's molecular weight of 785 g/mol violates Lipinski's rule of 5, making it difficult for the body to absorb efficiently. While some conversion to cycloastragenol occurs naturally in the stomach, the process is slow and incomplete.

We decided to source pure cycloastragenol directly, standardized to 10% potency. At just 490.70 g/mol, cycloastragenol meets optimal bioavailability parameters while delivering the same telomerase-activating benefits. This approach eliminates the conversion bottleneck, providing faster absorption and higher concentrations of the active compound. During beta testing, we observed notably more energizing effects compared to astragaloside IV, validating our decision to offer this superior form for those seeking effective cellular health supplements.

Benefits

• Promotes Neuroprotection: Supports healthy brain cell function by helping maintain telomere length in neurons, which naturally shorten with age and contribute to cognitive decline.
• Supports Immune Health: Maintains robust immune function by supporting the health of immune cells, which rely on telomerase activity to maintain their protective capabilities.
• Activate Telomerase: Directly stimulates the telomerase enzyme that adds protective DNA sequences to chromosome ends, helping preserve cellular integrity at a molecular weight of just 490.70 g/mol for optimal absorption.
• Helps Regulate Inflammation: Supports a balanced inflammatory response through its effects on cellular aging pathways, promoting healthy tissue function throughout the body.

Beyond telomere support, cycloastragenol delivers noticeable energy enhancement during daily use. This energizing quality stems from improved cellular health as telomerase activation supports mitochondrial function and overall cellular vitality, making it a comprehensive longevity compound that you can feel working.

Quality and Standardization

• 10% Cycloastragenol Standardization: Our extract is precisely standardized to contain 10% cycloastragenol by HPLC analysis, ensuring consistent potency and reliable telomerase-activating effects in every 100mg capsule.
• Premium Astragalus membranaceus Sourcing: We source high-quality Astragalus membranaceus root from established suppliers who specialize in this traditional longevity herb, providing optimal concentrations of bioactive triterpenoids.
• Advanced Extraction Process: Our cycloastragenol undergoes specialized extraction and purification methods to remove the bulky sugar groups found in astragaloside IV, resulting in superior bioavailability and faster absorption.
• Third-Party Purity Verification: Each batch is rigorously tested by independent laboratories for identity, potency, and purity, ensuring our cellular health supplements meet the highest quality standards.
• Molecular Weight Optimization: At 490.70 g/mol, our cycloastragenol complies with Lipinski's rule of 5 for optimal bioavailability, unlike heavier glycoside forms that may have absorption limitations.

Mechanism of Action

• Telomerase Enzyme Activation: Cycloastragenol directly binds to and activates the telomerase complex, specifically enhancing the activity of the TERT (telomerase reverse transcriptase) subunit that adds protective DNA sequences to chromosome ends.
• Enhanced Cellular Longevity Signaling: This compound modulates key longevity pathways including mTOR and AMPK signaling cascades, promoting cellular maintenance processes that support healthy aging at the mitochondrial level.
• Optimized Bioavailability Profile: Unlike its glycosylated counterpart astragaloside IV, cycloastragenol's smaller molecular weight (490.70 g/mol) allows for superior cellular uptake and faster distribution to target tissues without requiring gastric deglycosylation.
• Antioxidant Defense Upregulation: Cycloastragenol stimulates endogenous antioxidant enzyme systems including superoxide dismutase and catalase, creating a protective environment that helps preserve cellular health against oxidative damage.

Overview of the Science

Cycloastragenol demonstrates superior bioavailability characteristics compared to larger telomerase-activating compounds through its optimized molecular structure. Research shows cycloastragenol undergoes rapid intestinal absorption and exhibits favorable pharmacokinetic properties, with studies indicating effective first-pass metabolism that allows for efficient systemic delivery [1]. The compound's molecular weight of 490.70 g/mol places it just under Lipinski's rule of 5 threshold, contributing to enhanced cellular uptake and bioavailability compared to its glycosylated precursor astragaloside IV, which exceeds optimal molecular weight parameters at 785 g/mol.

This enhanced absorption profile translates to more efficient telomerase activation at lower doses, making cycloastragenol particularly valuable for supporting cellular health through direct enzyme modulation. The compound bypasses the deglycosylation step required for astragaloside IV conversion, potentially shortening time to peak plasma concentration (Tmax) while increasing maximum concentration (Cmax). This pharmacokinetic advantage may contribute to the compound's reported energizing effects and makes it an efficient option among cell regeneration supplements for those seeking telomere length support.

[1] Zhu J et al. Drug Metab Pharmacokinet. 2010;25(5):477-486.

Ingredients

Cycloastragenol:

• Astragalus membranaceus root extract
• 10% Cycloastragenol by HPLC
• 100mg per capsule

The 10% standardization represents one of the highest concentrations of bioactive cycloastragenol available in supplement form. This precise HPLC-verified potency ensures optimal telomerase activation potential while maintaining the molecular advantages that make cycloastragenol superior to larger, less bioavailable cellular health supplements. Unlike generic astragalus extracts that rely on variable deglycosylation processes, this direct cycloastragenol delivery provides consistent effects that support healthy aging pathways at the cellular level.