Infini-D | Optimized Vitamin D Stack

About Infini-D | Optimized Vitamin D Stack

Infini-D | Optimized Vitamin D Stack is a two capsule formulation delivering 125mcg of vitamin D split evenly between microencapsulated D3 (cholecalciferol) and microencapsulated D2 (ergocalciferol), rounded out with Maitake mushroom extract, tributyrin, and L-(+)-ergothioneine. This combination helps maintain healthy bone mineral density, supports balanced immune responses, and supports your overall cardiometabolic health. If you want a standalone vitamin D product built on more than a single form, this stack gives you a thoughtful upgrade over basic D3.

Our Infini-D | Optimized Vitamin D Stack Story

For many years we carried a vitamin D3 supplement that also included vitamin K2 to take advantage of the synergy between vitamin D and K. Over time it became clear there was also demand for a standalone vitamin D product. The problem was obvious: there are countless simple vitamin D supplements already out there, so we asked ourselves whether it was even worth releasing another basic D3 capsule. That question sent us down a long rabbit hole about how vitamin D actually works.

The first order of business was to look deeper at the two common forms, D2 and D3. D3 (cholecalciferol) is derived from cholesterol and is the form we synthesize when UV light hits our skin. D2 (ergocalciferol) is derived from ergosterol, a similar compound found in fungi and plants that also produces the vitamin when exposed to UV light. The common rhetoric says D3 is simply superior, but the research is more nuanced than that. Both forms absorb equally well and both activate the vitamin D receptor with similar potency.

What sets D2 and D3 apart, is that both forms have different pharmacokinetics. What's important to understand about vitamin D, is that both D2 and D3 are not active as is. They have to be converted to two different metabolites, the 25-hydroxy metabolites and then finally to the 1,25-dihydroxy metabolites. It's the 1,25-dihydroxy metabolites that mediate most of vitamin D's activity. This is where is gets interesting! D2 is harder to convert to its 25-hydroxy derivative and and once formed it is cleared more easily from circulation. Yet, it converts more efficiently to its active metabolite, 1,25-dihydroxy D2 (ercalcitriol), which is more metabolically stable and sticks around longer than 1,25-dihydroxy D3 (calcitriol). By combining both microencapsulated D3 and D2, we built a formulation that plays to the strengths of each rather than relying on a single form.

To further round out the formulation, we added in a high efficiency butyrate precursor, Tributyrin. The reason it was added, is because butyrate has been shown to upregulate the enzyme that is responsible for generating the active 1,25-dihydroxy vitamin D metabolites. Furthermore, butyrate has also been shown to upregulate vitamin D receptor activity, which is very relevant here because most of vitamin D's benefits are mediated through the vitamin D receptor. We also added Maitake for its beta-glucan content, which adds another precursor for butyrate production. Maitake also contains ergosterol, the precursor for vitamin D2, which appears to be able to positively influence endogenous vitamin D3 production! Beyond this, Maitake is also a fantastic immune boosting mushroom which helps further enhance vitamin D's immune boosting properties. Last but not least, L-(+)-ergothioneine, a mushroom derived antioxidant compound which confers additional immune boosting properties whilst also helping to protect the vitamin D from oxidation.

Benefits

• Healthy Bone Mineral Density: Consistent vitamin D intake helps maintain healthy bone mineral density, keeping your bones strong through the seasons.
• Balanced Immune Responses: Vitamin D supports balanced immune responses, so your body's defenses stay appropriately regulated.
• Cardiometabolic Support: This stack supports overall cardiometabolic health markers that matter for long-term wellbeing.
• Steady Mood: Correcting vitamin D insufficiency supports a positive, steady mood, especially during darker months when levels tend to dip.

Together, these effects make Infini-D a well rounded daily foundation: two forms of vitamin D plus supporting ingredients covering bone, immune, cardiometabolic, and mood support.

Quality and Standardization

• Dual Vitamin D Forms: Each serving delivers 125mcg of vitamin D from 62.5mcg microencapsulated D3 and 62.5mcg microencapsulated D2.
• Maitake Standardization: Our Maitake mushroom extract (Grifola frondosa, fruiting body) is dosed at 500mg and standardized to 0.5% ergosterol.
• Tributyrin Content: We include 200mg of tributyrin per two capsule serving.
• Ergothioneine Purity: We use 5mg of pure L-(+)-ergothioneine, the biologically relevant form.
• Verified Potency: Every batch is tested in-house via HPLC and UPLC to confirm identity, potency, and purity before release.

Mechanism of Action

• Two Conversion Pathways: D3 and D2 are hydroxylated to their 25-hydroxy derivatives (calcifediol and ercalcidiol) and then to the active 1,25-dihydroxy metabolites (calcitriol and ercalcitriol), both of which activate the vitamin D receptor.
• Metabolic Stability: Ercalcidiol converts efficiently to ercalcitriol, which is more metabolically stable and remains in circulation longer than calcitriol.
• Ergosterol Contribution: Maitake mushroom extract supplies ergosterol, the same fungal precursor from which D2 is naturally derived.
• Vitamin D Modulation: Tributyrin is a stable source of butyrate, which can upregulate CYP27B1, the enzyme that converts 25-hydroxy D3 and D2 into their active 1,25-dihydroxy forms, and can upregulate the vitamin D receptor (VDR).
• Cellular Antioxidant Uptake: L-(+)-ergothioneine is taken up by a dedicated cellular transporter, concentrating it in tissues where it functions as a protective antioxidant.

Overview of the Science

Vitamin D has been studied in the context of bone health. One trial found that vitamin D supplementation may help reduce wintertime and overall bone loss in healthy postmenopausal women [1], and another found that season and vitamin D status influence bone mineral density [2]. Other research found that vitamin D3 combined with calcium may support skeletal integrity in older women [3], while high-dose supplementation trials have examined its effects on volumetric bone density and bone strength [4].

Immune research points to a regulatory role for vitamin D. Studies indicate that vitamin D, alone or with marine omega-3 fatty acids, may help support balanced immune activity and healthy inflammatory markers [5][6], and that it may modulate maternal T-helper cytokine production [7]. A review has summarized how vitamin D interacts with the immune system more broadly [8].

Cardiometabolic research has also examined vitamin D across several populations. Meta-analyses and clinical trials suggest that supplementation may help support metabolic risk factors [9][10], and that combining it with magnesium or marine omega-3 fatty acids may support healthy blood pressure already within the normal range and other cardiometabolic markers [10][11].

[1] Dawson-Hughes B et al. Annals of Internal Medicine. 1991.

[2] Patel R et al. Osteoporosis International. 2001.

[3] Chapuy MC et al. New England Journal of Medicine. 1992.

[4] Burt LA et al. JAMA. 2019.

[5] Hahn J et al. BMJ. 2022.

[6] Costenbader KH et al. Clinical Chemistry. 2019.

[7] Ikemoto Y et al. Nutrients. 2018.

[8] Sirbe C et al. International Journal of Molecular Sciences. 2022.

[9] Abumweis S et al. Asia Pacific Journal of Clinical Nutrition. 2026.

[10] Talari HR et al. The British Journal of Nutrition. 2019.

[11] Cheung MM et al. Nutrition. 2022.

Ingredients