Buying supplements can be confusing, but it doesn't have to be.
Let us take the guess work out of analyzing the research, so you can understand the science behind Lion's Mane 8:1 Mushroom Extract's potential benefits.
LEARN MORE BELOW
Lion's Mane 8:1 Primary Benefits
Cognition
Nerve Support
Memory
Neuroprotection
The studies highlighted below are based on general research of Lion's Mane Mushroom, not specifically on Nootropics Depot's product. Lion's Mane can come in many forms and standardizations, and not all of them have the same efficacy. This research snapshot is intended to highlight the current state of the science regarding Lion's Mane, and should not be construed as direct evidence for the clinical efficacy of any one specific product.
Can Hericium erinaceus improve cognitive function?
Summary
These studies suggest Hericium erinaceus can improve cognitive function, enhance memory, and prevent cognitive decline in various models, including humans, mice, and zebrafish.
We've highlighted the some of the relevant studies below.
Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance
Nordic Lion's Mane extract improved working memory, complex attention, and reaction time, and perceptions of happiness over a 2 hour period.
Nutrients | M. Monica et al.| citations | 2023
Randomized Controlled Trial
Use of Hericium erinaceus as a potential therapeutic ...: a systematic review
Hericium erinaceus (Lion's Mane) can be useful in treating symptoms of cognitive impairment and moderate cognitive impairment
Debates em Psiquiatria | P. Cortonesi et al. | 0 citations | 2023
Systematic Review
Recovery from (mental illness) with Bioactive Substances in Hericium erinaceum
Lion's Mane (Yamabushitake) is a unique mushroom for maintaining brain health and improving cognitive functions.
International Journal of School and Cognitive Psychology | K. Inanaga et al. | 3 citations | 2015
A Systematic Review of in-vivo Studies on Dietary Mushroom Supplementation for Cognitive Impairment
Dietary supplementation with lion's mane, reishi, and cordyceps mushrooms may have a beneficial effect on cognitive impairment.
Current developments in nutrition | A. Nkodo et al. | 4 citations | 2019
Systematic Review
Very Rigerous Journal
Overview Of The Science
Summary
Hericium erinaceus, commonly known as Lion's Mane mushroom, shows promising potential for improving cognitive function. Research indicates that this fungus may enhance various aspects of brain health and cognitive performance.
Effects on Cognitive Function
Lion's Mane mushroom appears to have positive effects on cognitive function:
- Improved cognitive performance: A randomized, double-blind, placebo-controlled study found that oral intake of H. erinaceus significantly improved cognitive functions and prevented deterioration in older adults[1][2].
- Enhanced recognition memory: Dietary supplementation with Lion's Mane mushroom crude extracts significantly improved recognition memory in mice[3].
- Faster cognitive processing: In a study involving healthy young adults, participants performed quicker on the Stroop task 60 minutes after consuming H. erinaceus[4][5].
- Potential for cognitive decline prevention: Lion's Mane may help prevent cognitive decline, including Alzheimer's disease, according to studies in animals and humans[8].
Dosage and Duration The effective dosage and duration of H. erinaceus supplementation vary across studies:
- 12-week supplementation: Significant improvements in cognitive functions were observed after 12 weeks of supplementation[1][2].
- 28-day intervention: A trend towards reduced subjective stress was noted following a 28-day supplementation period[4][5].
- 16-week supplementation: Older adults with mild cognitive impairment showed improvements in cognitive test scores after taking 250 mg tablets containing Lion's Mane dry powder three times daily for 16 weeks[10].
Mechanism of Action The cognitive benefits of H. erinaceus are attributed to several mechanisms:
- Neurotrophic factors: Lion's Mane contains compounds that stimulate the production of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which promote brain cell growth and enhance memory[6][10].
- Neuronal growth: Extracts from Lion's Mane mushrooms have been shown to increase the size of growth cones in neurons, promoting new connections between brain cells[7].
- Neuroprotection: The mushroom exhibits neuroprotective properties, potentially helping to prevent or treat cognitive decline associated with neurodegenerative disorders[8].
Additional Benefits Besides cognitive enhancement, H. erinaceus may offer other neurological benefits:
- Reduced anxiety and depression: Some studies suggest that Lion's Mane mushroom may have anxiolytic and antidepressant effects[8].
- Nerve regeneration: The mushroom contains compounds that might promote the growth, survival, and function of both new and mature nerve cells in the brain and elsewhere[8].
Other Considerations While the results are promising, it's important to note:
- More research needed: Many studies have been conducted on animals or in vitro, and larger human trials are necessary to confirm the effects in diverse populations[6].
- Temporary effects: Some studies indicate that the cognitive benefits may diminish after discontinuing supplementation[10].
- Safety: H. erinaceus is generally considered safe, but as with any supplement, it's advisable to consult with a healthcare professional before use. Hericium erinaceus shows potential as a natural cognitive enhancer, but further research is needed to fully understand its effects and optimal use in humans.
Sources:
1. Improvement of cognitive functions by oral intake of Hericium erinaceus
2. Improvement of cognitive functions by oral intake of Hericium erinaceus
3. Lion's mane mushrooms may help improve memory, boost brain cell growth
4. Mushrooms for the mind: Research concludes Lion's Mane improves cognitive performance and reduces stress
5. The Acute and Chronic Effects of Lion's Mane Mushroom (Hericium erinaceus) on Cognitive Function and Mood in Healthy Adults: A Double-Blind, Placebo-Controlled Study
6. Latest Study Suggests Lion's Mane Mushrooms May Boost Brain Health
7. Mushrooms magnify memory by boosting nerve growth - UQ News
8. What Are the Health Benefits of Lion's Mane Mushrooms? - WebMD
9. Neurotrophic and Neuroprotective Effects of Hericium erinaceus
10. 5 Lion's Mane Mushroom Benefits
11. The Acute and Chronic Effects of Lion's Mane Mushroom (Hericium erinaceus) on Cognitive Function and Mood in Healthy Adults: A Double-Blind, Placebo-Controlled Study Citations:
[1] https://pubmed.ncbi.nlm.nih.gov/31413233/ [2] https://www.jstage.jst.go.jp/article/biomedres/40/4/40_125/_article [3] https://www.medicalnewstoday.com/articles/improving-memory-lions-mane-mushrooms-may-double-neuron-growth [4] https://www.nutraingredients.com/Article/2023/12/01/Mushrooms-for-the-mind-Research-concludes-Lion-s-Mane-improves-cognitive-performance-and-reduces-stress/ [5] https://pmc.ncbi.nlm.nih.gov/articles/PMC10675414/ [6] https://www.healthline.com/health-news/latest-study-suggests-lions-mane-mushrooms-may-boost-brain-heath [7] https://www.uq.edu.au/news/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth-0 [8] https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms [9] https://www.mdpi.com/1422-0067/24/21/15960 [10] https://health.clevelandclinic.org/lions-mane-mushrooms-benefits [11] https://pubmed.ncbi.nlm.nih.gov/38004235/
Can Hericium erinaceus support nerve health?
Summary
These studies suggest that Hericium erinaceus can support nerve health by promoting nerve regeneration, reducing inflammation and oxidative stress, and protecting against neurodegenerative conditions.
We've highlighted the some of the relevant studies below.
Therapeutic Potential of Hericium erinaceus
Lion's mane mushroom (H. erinaceus) promotes the expression of neurotrophic factors, which are associated with cell proliferation and nerve growth factors.
International Journal of Molecular Sciences | P. Chong et al. | 74 citations | 2019
Systematic Review
Highly Cited
Potential effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice
The complex extract of chlorella and lion's mane mushroom improved depression behavior in animals and increased brain-derived neurotrophic factor (BDNF) levels.
Frontiers in Nutrition | M. Chou et al. | 4 citations | 2022
Randomized Controlled Trial
Animal Trial
Lion’s Mane Mushroom- From Culinary to Medicine
Lion's Mane has a positive impact on nerve recovery and is emerging as a potent dietary supplement.
Annals of Innovation in Medicine | G. David et al. | 2023
Comprehensive Review
ALSUntangled #73: Lion's Mane
Lion's Mane has shown anti-inflammation, neuroprotection, and promoting neurite growth in various cell and animal models.
Amyotrophic lateral sclerosis & frontotemporal degeneration | M. Muhana et al. | 2023
Double-Blind Placebo Study
Overview Of The Science
Based on the available research, Hericium erinaceus (lion's mane mushroom) shows promising potential to support nerve health in several ways:
Effects on Nerve Health Hericium erinaceus contains bioactive compounds, particularly hericenones and erinacines, that have demonstrated neuroprotective and neurotrophic effects in studies. Some key findings include:
- Stimulation of nerve growth factor (NGF) synthesis, which is important for the growth, maintenance and survival of neurons
- Promotion of neurite outgrowth and nerve regeneration
- Neuroprotective effects against oxidative stress and neurotoxicity - Potential to reduce inflammation in the nervous system
Dosage and Duration
- Typical dosages used in studies range from 250 mg to 3 g per day of dried fruiting body extract
- Duration of supplementation in human trials has ranged from 4 weeks to 16 weeks
- Longer-term studies are still needed to determine optimal dosing and duration
Mechanism of Action The neuroprotective and neurotrophic effects appear to be mediated through several mechanisms:
- Increased production of nerve growth factor (NGF)
- Stimulation of neurite outgrowth
- Antioxidant and anti-inflammatory effects
- Potential modulation of the gut microbiome, which may influence the gut-brain axis
Additional Benefits Beyond nerve health, Hericium erinaceus has shown potential benefits for:
- Cognitive function and memory
- Mood and mental health (e.g. reducing anxiety and depression)
- Digestive health - Immune system support
Other Considerations
- Generally well-tolerated with few reported side effects
- More human clinical trials are needed to fully establish efficacy and optimal use
- Quality and standardization of supplements can vary, so choosing reputable sources is important
- Should be used under medical supervision, especially for those with existing health conditions or taking medications
While the research on Hericium erinaceus for nerve health is promising, more high-quality human studies are needed to conclusively determine its effects and optimal use. It shows potential as a complementary approach to supporting nerve health, but should not replace conventional medical treatments without professional guidance.
Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC10650066/ [2] https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms [3] https://pmc.ncbi.nlm.nih.gov/articles/PMC5987239/ [4] https://www.webmd.com/vitamins/ai/ingredientmono-1536/lions-mane-mushroom [5] https://www.mdpi.com/2309-608X/9/5/551 [6] https://restorativemedicine.org/journal/neurological-activity-lions-mane-hericium-erinaceus/ [7] https://pmc.ncbi.nlm.nih.gov/articles/PMC10675414/ [8] https://restorativemedicine.org/library/monographs/lions-mane/ [9] https://www.ncbi.nlm.nih.gov/books/NBK599740/ [10] https://www.medicalnewstoday.com/articles/32340
Can Hericium erinaceus support recognition memory?
Summary
These studies suggest Hericium erinaceus can support recognition memory.
We've highlighted the some of the relevant studies below.
Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance
Nordic Lion's Mane extract improved working memory, complex attention, and reaction time, and perceptions of happiness over a 2 hour period.
Nutrients | M. Monica et al.| citations | 2023
Randomized Controlled Trial
Effects of Dietary Supplementation with In Vitro-Cultivated Arboreal Medicinal Mushrooms on Long-Term Memory and Anxiety-Like Behavior of Male Mice.
Lion's mane (HE) supplementation in mice led to long-term memory improvement.
International journal of medicinal mushrooms | A. Fijalkowska et al. | 2023
Controlled Experimental Study
Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus.
The neurotrophic constituents of lion's mane mushroom may support the potential use of memory improvement.
Bioorganic & medicinal chemistry letters | | 22 citations | 2020
In-Vitro Trial
Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus).
Lion's mane mushroom has been traditionally used for memory impairment.
Journal of ethnopharmacology | S. Lee et al. | 13 citations | 2017
In-Vitro Trial
Overview Of The Science
Summary
Based on the available research, Hericium erinaceus (lion's mane mushroom) shows promising potential for supporting recognition memory:
Effects on Recognition Memory Several studies have demonstrated positive effects of Hericium erinaceus on recognition memory:
- A study in mice found that two-month oral supplementation with H. erinaceus extracts reversed age-related decline in recognition memory performance. The mushroom extract improved mice's ability to recognize novel objects in behavioral tests.
- Research in frail mice showed H. erinaceus supplementation significantly enhanced recognition memory compared to controls.
- In a human study, 12 weeks of H. erinaceus supplementation improved cognitive functions, including preventing deterioration in recognition memory as measured by the Mini Mental State Examination (MMSE).
Mechanism of Action The cognitive benefits of H. erinaceus appear to be mediated through several mechanisms:
- Promoting neurogenesis: Studies found H. erinaceus extracts increased the proliferation of hippocampal neurons and stimulated nerve growth factor (NGF) production.
- Enhancing neurotransmission: Research showed H. erinaceus increased the size of growth cones in neurons, potentially improving neural connections.
- Neuroprotective effects: Compounds in H. erinaceus demonstrated antioxidant and anti-inflammatory properties that may protect brain cells.
Dosage and Duration - Most studies used extracts or powders containing 1-3 grams of H. erinaceus daily.
- Benefits were typically observed after 4-12 weeks of consistent supplementation.
Additional Benefits Beyond recognition memory, H. erinaceus may offer other cognitive and mood benefits:
- Improved overall cognitive performance
- Reduced subjective stress and anxiety
- Potential neuroprotective effects against neurodegenerative diseases
Other Considerations
While results are promising, more large-scale human trials are needed to conclusively determine the effects of H. erinaceus on recognition memory in different populations. Individual responses may vary, and it's important to consult a healthcare professional before starting any new supplement regimen.
In conclusion, current evidence suggests Hericium erinaceus has potential to support recognition memory, particularly in aging populations, though more research is warranted to fully understand its effects and optimal use. Citations:
[9] https://www.mdpi.com/2309-608X/9/5/551 [10] https://www.mdpi.com/2079-7737/12/2/196
[11] https://www.sciencedirect.com/science/article/pii/S0149763424000162
Can Hericium erinaceus support neuroprotection?
Summary
These studies suggest Hericium erinaceus supports neuroprotection by stimulating nerve growth, regulating inflammation, reducing oxidative stress, and promoting neuronal survival and regeneration.
We've highlighted the some of the relevant studies below.
Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom
H. erinaceus polysaccharides have been demonstrated to possess neuroprotection and neuroregeneration properties.
International journal of biological macromolecules | Xirui He et al. | 129 citations | 2017
Literature Review
Highly Cited
Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages
Micronized Hericium erinaceus (HEM) showed excellent antioxidant efficacy and could recover dopamine levels in mice striatum.
Molecules | Chun-Hsien Hsu et al. | 1 citations | 2023
Non Randomized Controlled Trial
Animal Trial
In-Vitro Trial
Two New Cyathane Diterpenoids from Mycelial Cultures of the Medicinal Mushroom Hericium erinaceus and the Rare Species, Hericium flagellum
Erinacines from Lion's Mane mushroom (Hericium erinaceus) act on BDNF and NGF expression, suggesting potential neuroprotective effects.
International Journal of Molecular Sciences | Zeljka Rupcic et al. | 56 Citations 4 Influentials | 2018
In-Vitro Trial
Lion’s Mane (Hericium erinaceus): A Potential Treatment for Neurologic Disorders in Veterinary Medicine
Lion's Mane (LM) has potential neuroprotective actions, including stimulating nerve growth factor (NGF) and preventing and treating neurological conditions.
Journal of the American Holistic Veterinary Medical Association | I. Basko et al. | 2023
Literature Review
Overview Of The Science
Summary
Based on the available research, Hericium erinaceus (lion's mane mushroom) shows promising potential for neuroprotection and supporting cognitive function.
Here's an overview of the key evidence: Effects on Neuroprotection:
- Studies indicate H. erinaceus may have neuroprotective effects by stimulating nerve growth factor (NGF) release, regulating inflammatory processes, reducing oxidative stress, and protecting nerve cells from apoptosis.
- It has shown potential benefits in animal models of neurodegenerative conditions like Alzheimer's disease, Parkinson's disease, and peripheral nerve injury.
- Compounds like hericenones and erinacines found in H. erinaceus can cross the blood-brain barrier and promote NGF synthesis.
Dosage and Duration:
- Clinical studies have used doses ranging from 250 mg to 3 g per day, typically for 4-16 weeks.
- One study used 750 mg/day (as 250 mg 3x daily) for 16 weeks in people with mild cognitive impairment.
Mechanism of Action:
- Promotes nerve growth factor synthesis and secretion
- Exhibits antioxidant and anti-inflammatory effects
- May enhance neuroplasticity and neurogenesis
- Regulates neurotransmitter systems
Additional Benefits:
- Some evidence for potential antidepressant and anxiolytic effects
- May support overall cognitive function and memory
Other Considerations:
- Generally considered safe when used appropriately, but long-term safety data is limited
- May interact with medications that affect blood clotting or blood sugar
While the research is promising, more studies are needed to fully establish the neuroprotective effects and optimal use of H. erinaceus in humans. It shows potential as a complementary approach for supporting cognitive health and neuroprotection, but should not replace standard medical care for neurological conditions.
Citations:
[12] https://www.webmd.com/vitamins/ai/ingredientmono-1536/lions-mane-mushroom
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Buying supplements can be confusing, but it doesn't have to be.
Let us take the guess work out of analyzing the research, so you can be sure the benefits from the products you take are backed by valid science.
LEARN MORE BELOW
Lion's Mane 8:1 Primary Benefits
Cognition
Nerve Support
Memory
Neuroprotection
The studies highlighted below are based on general research of Lion's Mane Mushroom, not specifically on Nootropics Depot's product. Lion's Mane can come in many forms and standardizations, and not all of them have the same efficacy. This research snapshot is intended to highlight the current state of the science regarding Lion's Mane, and should not be construed as direct evidence for the clinical efficacy of any one specific product.
Does Black Ginger Increase Physical Energy?
Summary
These studies suggest Hericium erinaceus can improve cognitive function, enhance memory, and prevent cognitive decline in various models, including humans, mice, and zebrafish.
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Nordic Lion’s Mane Extracts on Cognitive Performance
Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance
Nordic Lion's Mane extract improved working memory, complex attention, and reaction time, and perceptions of happiness over a 2 hour period.
Nutrients | M. Monica et al.| citations | 2023
Randomized Controlled Trial
Use of Hericium erinaceus as a potential therapeutic
Use of Hericium erinaceus as a potential therapeutic ...: a systematic review
Hericium erinaceus (Lion's Mane) can be useful in treating symptoms of cognitive impairment and moderate cognitive impairment
Debates em Psiquiatria | P. Cortonesi et al. | 0 citations | 2023
Systematic Review
Recovery with Bioactive Substances in Hericium erinaceum
Recovery from (mental illness) with Bioactive Substances in Hericium erinaceum
Lion's Mane (Yamabushitake) is a unique mushroom for maintaining brain health and improving cognitive functions.
International Journal of School and Cognitive Psychology | K. Inanaga et al. | 3 citations | 2015
In-vivo Studies on Dietary Mushroom Supplementation for Cognitive Impairment
Black ginger extract increases physical fitness performance and muscular endurance by improving inflammation and energy metabolism
Dietary supplementation with lion's mane, reishi, and cordyceps mushrooms may have a beneficial effect on cognitive impairment.
Current developments in nutrition | A. Nkodo et al. | 4 citations | 2019
Systematic Review
Very Rigerous Journal
Overview Of The Science
Summary
Hericium erinaceus, commonly known as Lion's Mane mushroom, shows promising potential for improving cognitive function. Research indicates that this fungus may enhance various aspects of brain health and cognitive performance.
Effects on Cognitive Function
Lion's Mane mushroom appears to have positive effects on cognitive function:
- Improved cognitive performance: A randomized, double-blind, placebo-controlled study found that oral intake of H. erinaceus significantly improved cognitive functions and prevented deterioration in older adults[1][2].
- Enhanced recognition memory: Dietary supplementation with Lion's Mane mushroom crude extracts significantly improved recognition memory in mice[3].
- Faster cognitive processing: In a study involving healthy young adults, participants performed quicker on the Stroop task 60 minutes after consuming H. erinaceus[4][5].
- Potential for cognitive decline prevention: Lion's Mane may help prevent cognitive decline, including Alzheimer's disease, according to studies in animals and humans[8].
Dosage and Duration The effective dosage and duration of H. erinaceus supplementation vary across studies:
- 12-week supplementation: Significant improvements in cognitive functions were observed after 12 weeks of supplementation[1][2].
- 28-day intervention: A trend towards reduced subjective stress was noted following a 28-day supplementation period[4][5].
- 16-week supplementation: Older adults with mild cognitive impairment showed improvements in cognitive test scores after taking 250 mg tablets containing Lion's Mane dry powder three times daily for 16 weeks[10].
Mechanism of Action The cognitive benefits of H. erinaceus are attributed to several mechanisms:
- Neurotrophic factors: Lion's Mane contains compounds that stimulate the production of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), which promote brain cell growth and enhance memory[6][10].
- Neuronal growth: Extracts from Lion's Mane mushrooms have been shown to increase the size of growth cones in neurons, promoting new connections between brain cells[7].
- Neuroprotection: The mushroom exhibits neuroprotective properties, potentially helping to prevent or treat cognitive decline associated with neurodegenerative disorders[8].
Additional Benefits Besides cognitive enhancement, H. erinaceus may offer other neurological benefits:
- Reduced anxiety and depression: Some studies suggest that Lion's Mane mushroom may have anxiolytic and antidepressant effects[8].
- Nerve regeneration: The mushroom contains compounds that might promote the growth, survival, and function of both new and mature nerve cells in the brain and elsewhere[8].
Other Considerations While the results are promising, it's important to note:
- More research needed: Many studies have been conducted on animals or in vitro, and larger human trials are necessary to confirm the effects in diverse populations[6].
- Temporary effects: Some studies indicate that the cognitive benefits may diminish after discontinuing supplementation[10].
- Safety: H. erinaceus is generally considered safe, but as with any supplement, it's advisable to consult with a healthcare professional before use. Hericium erinaceus shows potential as a natural cognitive enhancer, but further research is needed to fully understand its effects and optimal use in humans.
Sources:
1. Improvement of cognitive functions by oral intake of Hericium erinaceus
2. Improvement of cognitive functions by oral intake of Hericium erinaceus
3. Lion's mane mushrooms may help improve memory, boost brain cell growth
4. Mushrooms for the mind: Research concludes Lion's Mane improves cognitive performance and reduces stress
5. The Acute and Chronic Effects of Lion's Mane Mushroom (Hericium erinaceus) on Cognitive Function and Mood in Healthy Adults: A Double-Blind, Placebo-Controlled Study
6. Latest Study Suggests Lion's Mane Mushrooms May Boost Brain Health
7. Mushrooms magnify memory by boosting nerve growth - UQ News
8. What Are the Health Benefits of Lion's Mane Mushrooms? - WebMD
9. Neurotrophic and Neuroprotective Effects of Hericium erinaceus
10. 5 Lion's Mane Mushroom Benefits
11. The Acute and Chronic Effects of Lion's Mane Mushroom (Hericium erinaceus) on Cognitive Function and Mood in Healthy Adults: A Double-Blind, Placebo-Controlled Study Citations:
[1] https://pubmed.ncbi.nlm.nih.gov/31413233/ [2] https://www.jstage.jst.go.jp/article/biomedres/40/4/40_125/_article [3] https://www.medicalnewstoday.com/articles/improving-memory-lions-mane-mushrooms-may-double-neuron-growth [4] https://www.nutraingredients.com/Article/2023/12/01/Mushrooms-for-the-mind-Research-concludes-Lion-s-Mane-improves-cognitive-performance-and-reduces-stress/ [5] https://pmc.ncbi.nlm.nih.gov/articles/PMC10675414/ [6] https://www.healthline.com/health-news/latest-study-suggests-lions-mane-mushrooms-may-boost-brain-heath [7] https://www.uq.edu.au/news/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth-0 [8] https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms [9] https://www.mdpi.com/1422-0067/24/21/15960 [10] https://health.clevelandclinic.org/lions-mane-mushrooms-benefits [11] https://pubmed.ncbi.nlm.nih.gov/38004235/
Can Hericium erinaceus support nerve health?
Summary
These studies suggest that Hericium erinaceus can support nerve health by promoting nerve regeneration, reducing inflammation and oxidative stress, and protecting against neurodegenerative conditions.
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Therapeutic Potential of Hericium erinaceus
Therapeutic Potential of Hericium erinaceus
Lion's mane mushroom (H. erinaceus) promotes the expression of neurotrophic factors, which are associated with cell proliferation and nerve growth factors.
International Journal of Molecular Sciences | P. Chong et al. | 74 citations | 2019
Systematic Review
Highly Cited
Chlorella and lion's mane mushroom complex in aged SAMP8 mice
Potential effects of a dietary supplement from the chlorella and lion's mane mushroom complex in aged SAMP8 mice
The complex extract of chlorella and lion's mane mushroom improved depression behavior in animals and increased brain-derived neurotrophic factor (BDNF) levels.
Frontiers in Nutrition | M. Chou et al. | 4 citations | 2022
Randomized Control Trial
Animal Trial
Lion’s Mane Mushroom- From Culinary to Medicine
Lion’s Mane Mushroom- From Culinary to Medicine
Lion's Mane has a positive impact on nerve recovery and is emerging as a potent dietary supplement.
Annals of Innovation in Medicine | G. David et al. | 2023
Comprehensive Review
ALSUntangled #73: Lion's Mane
ALSUntangled #73: Lion's Mane
Lion's Mane has shown anti-inflammation, neuroprotection, and promoting neurite growth in various cell and animal models.
Amyotrophic lateral sclerosis & frontotemporal degeneration | M. Muhana et al. | 2023
Double Blind Placebo Study
Overview Of The Science
Based on the available research, Hericium erinaceus (lion's mane mushroom) shows promising potential to support nerve health in several ways:
Effects on Nerve Health Hericium erinaceus contains bioactive compounds, particularly hericenones and erinacines, that have demonstrated neuroprotective and neurotrophic effects in studies. Some key findings include:
- Stimulation of nerve growth factor (NGF) synthesis, which is important for the growth, maintenance and survival of neurons
- Promotion of neurite outgrowth and nerve regeneration
- Neuroprotective effects against oxidative stress and neurotoxicity - Potential to reduce inflammation in the nervous system
Dosage and Duration
- Typical dosages used in studies range from 250 mg to 3 g per day of dried fruiting body extract
- Duration of supplementation in human trials has ranged from 4 weeks to 16 weeks
- Longer-term studies are still needed to determine optimal dosing and duration
Mechanism of Action The neuroprotective and neurotrophic effects appear to be mediated through several mechanisms:
- Increased production of nerve growth factor (NGF)
- Stimulation of neurite outgrowth
- Antioxidant and anti-inflammatory effects
- Potential modulation of the gut microbiome, which may influence the gut-brain axis
Additional Benefits Beyond nerve health, Hericium erinaceus has shown potential benefits for:
- Cognitive function and memory
- Mood and mental health (e.g. reducing anxiety and depression)
- Digestive health - Immune system support
Other Considerations
- Generally well-tolerated with few reported side effects
- More human clinical trials are needed to fully establish efficacy and optimal use
- Quality and standardization of supplements can vary, so choosing reputable sources is important
- Should be used under medical supervision, especially for those with existing health conditions or taking medications
While the research on Hericium erinaceus for nerve health is promising, more high-quality human studies are needed to conclusively determine its effects and optimal use. It shows potential as a complementary approach to supporting nerve health, but should not replace conventional medical treatments without professional guidance.
Citations:
[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC10650066/ [2] https://www.webmd.com/diet/what-are-the-health-benefits-of-lions-mane-mushrooms [3] https://pmc.ncbi.nlm.nih.gov/articles/PMC5987239/ [4] https://www.webmd.com/vitamins/ai/ingredientmono-1536/lions-mane-mushroom [5] https://www.mdpi.com/2309-608X/9/5/551 [6] https://restorativemedicine.org/journal/neurological-activity-lions-mane-hericium-erinaceus/ [7] https://pmc.ncbi.nlm.nih.gov/articles/PMC10675414/ [8] https://restorativemedicine.org/library/monographs/lions-mane/ [9] https://www.ncbi.nlm.nih.gov/books/NBK599740/ [10] https://www.medicalnewstoday.com/articles/32340
Can Hericium erinaceus support recognition memory?
Summary
These studies suggest Hericium erinaceus can support recognition memory.
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Effects of Guayusa Tea and Lion’s Mane Extracts on Cognitive Performance
Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance
Nordic Lion's Mane extract improved working memory, complex attention, and reaction time, and perceptions of happiness over a 2 hour period.
Nutrients | M. Monica et al.| citations | 2023
Randomized Controlled Trial
In Vitro-Cultivated Arboreal Medicinal Mushrooms on Long-Term Memory
Effects of Dietary Supplementation with In Vitro-Cultivated Arboreal Medicinal Mushrooms on Long-Term Memory and Anxiety-Like Behavior of Male Mice.
Lion's mane (HE) supplementation in mice led to long-term memory improvement.
International journal of medicinal mushrooms | A. Fijalkowska et al. | 2023
Controlled Expiremental Study
Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus.
Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus.
The neurotrophic constituents of lion's mane mushroom may support the potential use of memory improvement.
Bioorganic & medicinal chemistry letters | | 22 citations | 2020
In-Vitro Trial
Inhibitory constituents of the fruiting body of lion's mane mushroom
Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus).
Lion's mane mushroom has been traditionally used for memory impairment.
Journal of ethnopharmacology | S. Lee et al. | 13 citations | 2017
In-Vitro Trial
Overview Of The Science
Summary
Based on the available research, Hericium erinaceus (lion's mane mushroom) shows promising potential for supporting recognition memory:
Effects on Recognition Memory Several studies have demonstrated positive effects of Hericium erinaceus on recognition memory:
- A study in mice found that two-month oral supplementation with H. erinaceus extracts reversed age-related decline in recognition memory performance. The mushroom extract improved mice's ability to recognize novel objects in behavioral tests.
- Research in frail mice showed H. erinaceus supplementation significantly enhanced recognition memory compared to controls.
- In a human study, 12 weeks of H. erinaceus supplementation improved cognitive functions, including preventing deterioration in recognition memory as measured by the Mini Mental State Examination (MMSE).
Mechanism of Action The cognitive benefits of H. erinaceus appear to be mediated through several mechanisms:
- Promoting neurogenesis: Studies found H. erinaceus extracts increased the proliferation of hippocampal neurons and stimulated nerve growth factor (NGF) production.
- Enhancing neurotransmission: Research showed H. erinaceus increased the size of growth cones in neurons, potentially improving neural connections.
- Neuroprotective effects: Compounds in H. erinaceus demonstrated antioxidant and anti-inflammatory properties that may protect brain cells.
Dosage and Duration - Most studies used extracts or powders containing 1-3 grams of H. erinaceus daily.
- Benefits were typically observed after 4-12 weeks of consistent supplementation.
Additional Benefits Beyond recognition memory, H. erinaceus may offer other cognitive and mood benefits:
- Improved overall cognitive performance
- Reduced subjective stress and anxiety
- Potential neuroprotective effects against neurodegenerative diseases
Other Considerations
While results are promising, more large-scale human trials are needed to conclusively determine the effects of H. erinaceus on recognition memory in different populations. Individual responses may vary, and it's important to consult a healthcare professional before starting any new supplement regimen.
In conclusion, current evidence suggests Hericium erinaceus has potential to support recognition memory, particularly in aging populations, though more research is warranted to fully understand its effects and optimal use.
Citations:
[9] https://www.mdpi.com/2309-608X/9/5/551 [10] https://www.mdpi.com/2079-7737/12/2/196
[11] https://www.sciencedirect.com/science/article/pii/S0149763424000162
Can Hericium erinaceus support neuroprotection?
Summary
These studies suggest Hericium erinaceus supports neuroprotection by stimulating nerve growth, regulating inflammation, reducing oxidative stress, and promoting neuronal survival and regeneration.
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom
Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom
H. erinaceus polysaccharides have been demonstrated to possess neuroprotection and neuroregeneration properties.
Molecules | Chun-Hsien Hsu et al. | 1 citations | 2023
Literature Review
Highly Cited
Antioxidative Activities of Cultivated Hericium erinaceus
Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages
Micronized Hericium erinaceus (HEM) showed excellent antioxidant efficacy and could recover dopamine levels in mice striatum.
Molecules | Chun-Hsien Hsu et al. | 1 citations | 2023
Non Randomized Controlled Trial
Animal Trial
In-Vitro Trial
Cyathane Diterpenoids from Mycelial Cultures of Hericium erinaceus
Two New Cyathane Diterpenoids from Mycelial Cultures of the Medicinal Mushroom Hericium erinaceus and the Rare Species, Hericium flagellum
Erinacines from Lion's Mane mushroom (Hericium erinaceus) act on BDNF and NGF expression, suggesting potential neuroprotective effects.
International Journal of Molecular Sciences | Zeljka Rupcic et al. | 56 Citations 4 Influential | 2018
In Vitro Experiment
Lion’s Mane: A Potential Treatment for Neurologic Disorders in Veterinary Medicine
Lion’s Mane (Hericium erinaceus): A Potential Treatment for Neurologic Disorders in Veterinary Medicine
Lion's Mane (LM) has potential neuroprotective actions, including stimulating nerve growth factor (NGF) and preventing and treating neurological conditions.
Journal of the American Holistic Veterinary Medical Association | I. Basko et al. | 2023
Literature Review
Overview Of The Science
Summary
Based on the available research, Hericium erinaceus (lion's mane mushroom) shows promising potential for neuroprotection and supporting cognitive function.
Here's an overview of the key evidence: Effects on Neuroprotection:
- Studies indicate H. erinaceus may have neuroprotective effects by stimulating nerve growth factor (NGF) release, regulating inflammatory processes, reducing oxidative stress, and protecting nerve cells from apoptosis.
- It has shown potential benefits in animal models of neurodegenerative conditions like Alzheimer's disease, Parkinson's disease, and peripheral nerve injury.
- Compounds like hericenones and erinacines found in H. erinaceus can cross the blood-brain barrier and promote NGF synthesis.
Dosage and Duration:
- Clinical studies have used doses ranging from 250 mg to 3 g per day, typically for 4-16 weeks.
- One study used 750 mg/day (as 250 mg 3x daily) for 16 weeks in people with mild cognitive impairment.
Mechanism of Action:
- Promotes nerve growth factor synthesis and secretion
- Exhibits antioxidant and anti-inflammatory effects
- May enhance neuroplasticity and neurogenesis
- Regulates neurotransmitter systems
Additional Benefits:
- Some evidence for potential antidepressant and anxiolytic effects
- May support overall cognitive function and memory
Other Considerations:
- Generally considered safe when used appropriately, but long-term safety data is limited
- May interact with medications that affect blood clotting or blood sugar
While the research is promising, more studies are needed to fully establish the neuroprotective effects and optimal use of H. erinaceus in humans. It shows potential as a complementary approach for supporting cognitive health and neuroprotection, but should not replace standard medical care for neurological conditions.
Citations:
[12] https://www.webmd.com/vitamins/ai/ingredientmono-1536/lions-mane-mushroom
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