Research Snapshot
Magtein
A synthesis of the peer-reviewed evidence for Magtein across sleep, memory, mood and cognition, graded by scientific consensus and reviewed by our Scientific Advisory Board.
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SleepDoes Magnesium support sleep?
Evidence from 10 studies
What the research shows
These studies suggest magnesium supplementation may improve sleep quality, reduce sleep onset latency, and support healthy sleep, particularly in older adults.
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Sleep Medicine | R. Allen et al. | 3 | 2003
Randomized Control Trial (RCT)
Oral magnesium supplementation improves slow-wave sleep, delta and sigma frequency EEG power, and reverses the aging effect on cortisol release and renin-angiotensin-aldosterone system activity in elderly adults.
Sleep | Y. Zhang et al. | 6 | 2021
Very Rigorous Journal
Higher magnesium intake is associated with better sleep quality and reduced likelihood of short sleep (7 hours).
Nutrition Journal | O. Barna et al. | 2 | 2021
Randomized Control Trial (RCT) , Very Rigorous Journal
Magnesium oxide monohydrate treatment resulted in greater improvement in sleep quality compared to placebo.
Pakistan Journal of Health Sciences | A. Liaqat et al. | 0 | 2023
Randomized Control Trial (RCT)
Magnesium supplementation in elderly people has highly significant effects in improving insomnia and quality of sleep.
MemoryDoes Magnesium L-Threonate Support Memory?
Evidence from 10 studies
What the research shows
These studies suggest that Magnesium L-Threonate supports memory and cognitive function in both animal models and humans.
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Nutrients | C. Zhang et al. | 3 | 2022
Randomized Control Trial (RCT) , Very Rigorous Journal
Magnesium L-threonate supplementation, like Magtein®PS, significantly improves memory and cognition in healthy Chinese adults.
Neuron | I. Slutsky et al. | 293 | 2010
Randomized Control Trial (RCT) , Animal Trial , Rigorous Journal
Increasing brain magnesium enhances learning, working memory, and short- and long-term memory in rats.
eLife | Q. Sun et al. | 31 | 2016
Animal Trial
L-TAMS, a combination of L-threonate and magnesium, can enhance learning and memory in young rats and prevent memory decline in aging rats and Alzheimer's disease model mice.
Pain physician | D. Toffa et al. | 1 | 2018
Randomized Control Trial (RCT) , Animal Trial
Magnesium and calcium reduce the severity of spatial memory impairments in a mouse model of mesial temporal lobe epilepsy.
MoodCan magnesium support mood?
Evidence from 16 studies
What the research shows
Some studies suggest magnesium supplementation can improve mood and support healthy mood, while other studies indicate it may not be superior to placebo in certain conditions.
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BJPsych Open | D. Phelan et al. | 25 | 2018
Rigorous Journal
Magnesium supplementation was associated with a decline in depressive symptoms in uncontrolled trials but not in placebo-controlled trials.
PLoS ONE | E. Tarleton et al. | 79 | 2017
Randomized Control Trial (RCT) , Rigorous Journal
Magnesium supplementation for 6 weeks resulted in a clinically significant net improvement in depression symptoms and anxiety scores.
Obstetrics & Gynecology | F. Facchinetti et al. | 156 | 1991
Randomized Control Trial (RCT) , Highly Cited
Oral magnesium supplementation significantly reduced premenstrual mood changes.
Nutrients | A. Botturi et al. | 61 | 2020
Very Rigorous Journal
Supplementation with magnesium could be beneficial in reducing depressive symptoms.
CognitionDoes Magnesium L-threonate improve cognition?
Evidence from 10 studies
What the research shows
These studies suggest that Magnesium L-threonate improves cognition in both animal models and humans, including in human research.
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Nutrients | Chengxiang Zhang et al. | 8 | 2022
Randomized Control Trial (RCT) , Very Rigorous Journal
Magnesium L-threonate supplementation, specifically Magtein®PS, significantly improves memory and cognition in healthy Chinese adults.
Alzheimer's & Dementia : Translational Research & Clinical Interventions | M. Tao et al. | 5 | 2022
Rigorous Journal
Higher magnesium intake is associated with better cognition in older adults.
Current developments in nutrition | N. Peeri et al. | 0 | 2019
Very Rigorous Journal
Higher serum 25(OH)D levels were associated with reduced risk of low cognitive function in older adults, and this association appeared to be modified by the intake level of magnesium.
Journal of Alzheimer's disease : JAD | Z. Zhu et al. | 14 | 2020
Randomized Control Trial (RCT) , Rigorous Journal
Reducing the Ca:Mg ratio to around 2.3 by personalized magnesium supplementation significantly improved cognitive function by 9.1% in those aged over 65 years old with a high dietary Ca:Mg ratio.
Reviewed by Experts
Every research snapshot is checked by our independent Scientific Advisory Board: physicians, botanists and pharmacology researchers who verify the evidence grading and its interpretation.
Kerry Hughes
M.Sc., RH(AHG), FDN-P
Ethnobotanist & herbalist; Berkeley Herbal Center; principal at EthnoPharm.
View full profile →Lance Dreher
PhD, Nutritional Counseling
Performance nutrition & conditioning; four decades of applied training science.
View full profile →Dr. Lindsey Faucette
DO, FAAFP
Board-certified in Family & Integrative Medicine; Touro University College of Osteopathic Medicine.
View full profile →Francisco Chacon
PhD, Plant Biology
Botanical natural products & phytochemistry researcher, Penn State University.
View full profile →Meet the full Scientific Advisory Board →
How We Grade Consensus
For each benefit we retrieve the relevant peer-reviewed literature and classify every study by whether its findings support (Yes), partially or conditionally support (Possibly), or do not support (No) the claim. The donut shows the share of studies in each category; N is the number of studies analyzed for that benefit.
Grades reflect the weight and direction of the current evidence, not a guarantee of outcome, and the interpretation is verified by the Scientific Advisory Board.