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Maitake Mushroom Extract Powder

Beta glucan-rich mushroom extract that supports immune health, cognitive function, metabolism, and overall well-being.

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Maitake Mushroom Extract Powder

Beta glucan-rich mushroom extract that supports immune health, cognitive function, metabolism, and overall well-being.

(8 Reviews) Write a Review

View All Reviews

Available in multiple forms! Click Here for:
  • Whole Fruiting Body Extract Only
  • Rich in Immune-Supporting Beta Glucans
  • AMPA Receptor Cognitive Support
  • Traditional Japanese Medicinal Mushroom

3rd Party Lab Tested & Verified

See Why ND Maitake Is The Best

Updated On: 05/23/2026

$19.99 - $29.99

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ATTENTION: This product does not include a scoop. Learn more

Benefits

When You'll Notice Effects

2-3 Weeks

Maitake Mushroom (Grifola frondosa) is a polypore mushroom valued in traditional herbology. It supports immune health, cognitive function, metabolism, and cellular health. Rich in beta glucans, it also promotes overall well-being and emotional health

  • Immune
  • Cognition
  • Metabolism
  • Mood

Why ND Maitake Mushroom?

A Maitake extract standardized for beta-glucan immune and cognitive support
test

How To Take

Dose
Dose

500mg (Per Serving)

Timing
Timing

Flexible

How to Take
How to Take

With Or Without Food

Frequency
Frequency

1-2 Times Daily

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  • About Maitake Mushroom Extract Powder

    Maitake Mushroom Extract Powder delivers a premium whole fruiting body extract of Grifola frondosa, standardized to 30% beta-glucans. This organic extract supports immune function, cellular health, and metabolic processes while providing unique cognitive benefits through AMPA receptor interaction.

    Our Maitake Story

    Most mushroom extracts on the market focus solely on beta-glucan content without considering the specific bioactive compounds that make each species unique. While studying Maitake's traditional use in Japanese herbology, we discovered research showing this particular mushroom contains Proteo-β-glucan, a specialized beta-glucan variant that interacts with AMPA receptors in ways other medicinal mushrooms do not.

    We create an extract that preserves these unique compounds while meeting rigorous standardization requirements. We source only certified organic whole fruiting bodies and use specialized extraction methods that maintain the integrity of both the standard beta-glucans and the unique Proteo-β-glucan fraction. This dual-focused extraction ensures you receive both the broad-spectrum immune benefits and the distinctive cognitive and mood-supporting effects that make Maitake stand out among functional mushrooms.

    Benefits

    • Support Immune System Function: Maitake delivers 30% beta-glucans that support your body's natural immune defenses through specialized Proteo-β-glucan compounds unique to this mushroom.
    • Support Memory And Focus: Research shows Maitake acts as an AMPA receptor agonist, promoting synaptic transmission in the central nervous system for enhanced cognition and mental clarity.
    • Support Healthy Metabolic Function: Rich in essential minerals like potassium, calcium, and magnesium, Maitake helps maintain healthy metabolism and supports optimal cellular energy production.
    • Support Mood And Overall Well-Being: Animal studies demonstrate that Maitake promotes positive emotional behavior and balanced stress response through its interaction with glutamate receptors in the brain.

    Maitake's nutritional profile extends beyond its active compounds, providing B2, D2, and niacin vitamins alongside fiber and amino acids that support overall vitality. This whole fruiting body extract maintains the mushroom's natural synergy of bioactive components, making it one of the most comprehensively studied mushrooms for immunity and wellness support.

    Quality and Standardization

    • Beta-Glucan Standardization: Our Maitake extract is standardized to a minimum 30% beta-glucans by HPLC testing, ensuring consistent bioactive potency with every serving.
    • Whole Fruiting Body Source: We use only certified organic whole fruiting bodies of Grifola frondosa, not mycelium on grain, providing the full spectrum of naturally occurring cellular health supplements compounds.
    • Dual Extraction Process: Our extract undergoes both hot water and alcohol extraction methods to concentrate both water-soluble beta-glucans and alcohol-soluble triterpenes for maximum bioavailability.
    • Third-Party Verification: Every batch undergoes comprehensive testing for purity, potency, and identity verification through independent laboratories to guarantee product quality.
    • Proteo-β-Glucan Content: This extract contains the specific Proteo-β-glucan fraction unique to Maitake mushrooms, which research indicates is responsible for the mood and cognitive benefits.

    Mechanism of Action

    • Beta-Glucan Immune Support: Maitake's specialized Proteo-β-glucan compounds support healthy immune cell function and your body's natural surveillance capabilities.
    • AMPA Receptor Interaction: The bioactive compounds in Maitake interact with AMPA glutamate receptors in the brain, supporting healthy synaptic plasticity and neurotransmitter communication pathways.
    • Metabolic Support: Research indicates Maitake supports healthy metabolic processes and cellular energy production, promoting optimal nutrient utilization.
    • Cellular Communication Support: The mushroom's polysaccharide compounds promote healthy cell-to-cell communication through balanced cytokine signaling and healthy stress response mechanisms.

    Overview of the Science

    Maitake mushroom demonstrates remarkable adaptability in supporting the body's natural equilibrium through multiple pathways [1]. Research has identified specific Proteo-β-glucan compounds that support healthy immune responses while simultaneously influencing neurotransmitter activity. Studies investigating Maitake's traditional use for "balancing altered body systems" have revealed measurable effects on both immune cell activation and metabolic function. The mushroom's unique ability to act as an AMPA receptor agonist while providing immune-modulating beta-glucans creates a dual-action mechanism that supports both cognitive and physical well-being. Animal studies have shown that subjects consuming Maitake-dense diets exhibited enhanced stress resilience and improved behavioral responses to environmental challenges.

    The standardized 30% beta-glucan content in our extract ensures consistent delivery of bioactive compounds across multiple body systems. Unlike synthetic immune modulators, Maitake's antioxidant support properties work synergistically with its metabolic benefits to support overall vitality. The whole fruiting body extraction process preserves the full spectrum of nutrients including essential minerals like potassium, calcium, and magnesium alongside B-vitamins that support energy production. This comprehensive nutritional profile makes Maitake particularly valuable for individuals seeking a natural approach to maintaining peak performance and resilience.

    [1] Wesa KM et al. [...] Immunol Immunother. 2015;64(2):237-47.

    Ingredients

    Grifola frondosa Extract (fruiting body):

    • 500mg per serving
    • Fruiting body extract
    • No fillers or additives

    Our Maitake extract uses only the fruiting body rather than mycelium grown on grain substrates. This distinction matters because fruiting bodies contain the full spectrum of bioactive compounds that make maitake valuable, including beta-glucans and other polysaccharides in their natural ratios. Many commercial maitake products use cheaper myceliated grain, which dilutes the active compounds with starchy fillers. By sourcing pure fruiting body extract, this powder delivers the concentrated bioactive profile that research has focused on.

    LACTOSE FREE
    GLUTEN FREE
    VEGAN
  • Lab Testing Results / Certificate of Analysis (COA)

  • Frequently asked questions

    1. Can I take Maitake powder with other mushroom supplements?

      Yes, Maitake powder combines well with other mushroom supplements. Its unique beta-glucan compounds and AMPA receptor activity complement varieties like Lion's Mane, Reishi, or Cordyceps for targeting multiple wellness pathways.

    2. How much Nootropics Depot Maitake should I take daily?

      We recommend 500,1000mg of Maitake Mushroom Extract Powder once or twice daily. No scoop is included, so a milligram scale is needed for accurate dosing of this 30% beta-glucan extract.

    3. Does Maitake powder taste too strong for smoothies?

      Maitake Mushroom Extract Powder has a mild, earthy flavor that blends well in smoothies, especially with fruit. Start with a smaller dose to find your preferred amount.

    4. How does Maitake's Proteo-β-glucan differ from regular beta-glucans?

      Maitake's Proteo-β-glucans are protein-bound beta-glucan complexes that offer enhanced bioactivity compared to standard beta-glucans found in other mushrooms. These unique compounds provide both immune-modulating effects and neurotransmitter support through AMPA receptor interaction, creating a dual-action mechanism not found in regular beta-glucans.

    5. Can I stack Maitake with Lion's Mane and Reishi?

      Yes, Maitake stacks well with Lion's Mane and Reishi. Each offers complementary support: Maitake for immune, metabolic, and AMPA receptor activity; Lion's Mane for nerve growth factor; and Reishi for stress response and sleep quality.

    6. Why doesn't Maitake produce noticeable effects like other mushrooms?

      Maitake works as an adaptogenic immune modulator, not an acute performance enhancer, so benefits build gradually over 2-3 weeks through beta-glucan immune support and gentle AMPA receptor interaction. Expect improved overall well-being rather than distinct immediate effects.

    7. Is Nootropics Depot's Maitake extract organic and third-party tested?

      Yes, our Maitake Mushroom Extract Powder is certified organic, third-party tested for purity, potency, heavy metals, and microbial contaminants, and verified at 30% beta-glucans. Every batch comes with a Certificate of Analysis.

    8. How do you cook Maitake mushrooms?

      Our Maitake Mushroom Extract Powder is a concentrated supplement, not a cooking ingredient. For cooking, use fresh whole mushrooms from a grocery store; our extract delivers 30% beta-glucans as a dietary supplement.

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Maitake Mushroom Extract Powder

Maitake Mushroom Extract Powder

$19.99 - $29.99