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Premium Quality Supplement Recommendations

BUYING GUIDE | Premium Quality Supplement Recommendations

Have a flexible budget available for nootropics and supplements? Consider these premium quality nootropics and supplements from Nootropics Depot. While quality and price do not always have a direct correlation, there are instances where certain dietary supplements are priced the way they are for very good reason. Whether it be a novel ingredient/formulation, clinically-studied for efficacy, or a unique standardization/product feature(s), this buying guide represents our top supplement recommendations where price is not the most important consideration. Browse 3 different high-quality supplement suggestions for 20 different uses including memory, focus, motivation, energy, mood, stress management and more. Use the menu below to get started.

Looking for more economically-mindful suggestions? Check out our Budget-Friendly Recommendations Guide.

BUYING GUIDE | Premium Quality Supplement Recommendations

Have a flexible budget available for nootropics and supplements? Consider these premium quality nootropics and supplements from Nootropics Depot. While quality and price do not always have a direct correlation, there are instances where certain dietary supplements are priced the way they are for very good reason. Whether it be a novel ingredient/formulation, clinically-studied for efficacy, or a unique standardization/product feature(s), this buying guide represents our top supplement recommendations where price is not the most important consideration. Browse 3 different high-quality supplement suggestions for 20 different uses including memory, focus, motivation, energy, mood, stress management and more. Use the menu below to get started.

Looking for more economically-mindful suggestions? Check out our Budget-Friendly Recommendations Guide.

General Premium Essentials*

We often get so caught up in pushing the boundaries that it becomes easy to forget about the basics! With that in mind though, the basics form the foundations of our stacks, so it is worth spending some time optimizing the basics. We are often short on magnesium, omega 3’s, and zinc and these three premium quality supplements will help address these issues very efficiently!

A unique high bioavailability formulation of magnesium, utilizing sucrosome technology*

Provides magnesium with no other overt auxiliary effects that are seen with magnesium glycinate (relaxation) and Magtein (memory), ideal for use in stacks*

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A highly bioavailable fish oil formulation*

No fish burps common with lower-tier fish oils*

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A unique high bioavailability formulation of zinc, utilizing sucrosome technology*

Sensible dose of zinc, which is not commonly seen with other zinc supplements*

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For Memory*

With the amount of information we need to absorb and store on a daily basis, it is no surprise that we sometimes feel like we have hit the capacity of our memory storage. Luckily, these three premium memory supplements may help you expand that storage capacity!

Clinically studied memory promoter*

An excellent source of choline and uridine*

Also great for focus*

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A very unique flavone*

Mimics the effects of BDNF and helps promote neuroplasticity*

✔ Also great for mood*

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A high potency, 100% fruiting body, dual extract*

An excellent choice for promoting general memory and neuroplasticity*

Also great for immune function*

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For Focus*

Performing at a high level consistently requires laser focus, but this is not always the easiest task to pull off. These three premium supplements do a fantastic job of dialing in focus without producing all too much stimulation, which is more often than not the hallmark of focus supplements. However, large amounts of stimulation all day long can actually get in the way of focus, for ideal focus we actually want to maintain a sharp but relaxed mind, and that is exactly what these three premium focus supplements may help you achieve!

An advanced sage extract*

A unique blend of calming and focus enhancing effects*

Also great for promoting general cognitive function*

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A novel caffeine-like compound*

Smoother and more uplifting effects than caffeine*

Longer lasting than caffeine, allowing for lower daily doses*

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Highly advanced Panax ginseng formulation*

Takes effect very quickly*

Produces robust focus with an undercurrent of crisp, smooth energy*

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For Motivation*

Sometimes the only thing that separates us from our goals is a dire lack of motivation. We have all the tools necessary to accomplish our goals, if only somebody could please put the key in the ignition to get things started! This is where these three premium motivation supplements can lend a helping hand to get projects and tasks moving at a solid pace!

A novel caffeine-like compound*

Effects kick in very rapidly*

Much pushier than caffeine which translates to a great boost to motivation*

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A highly potent Tongkat Ali extract*

Helps promote T levels, which in turn may promote motivation*

Also great for promoting physical strength and mood*

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Technically a ‘budget supplement’ but produces premium effects!*

An excellent catecholamine reuptake inhibitor*

Also great for dialing in focus and mood*

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For Energy*

With the busy lives most of us lead in this day and age, we oftentimes have to make compromises that leave us with low energy levels. While the right amount of sleep is the absolute best way to promote daytime energy levels, a good night of sleep is not always realistically feasible. Luckily, these three premium supplements may help lend a helping hand, allowing you to perform at your best!

A highly advanced caffeine formulation*

Effects kick in very rapidly, while also lasting all-day*

Also great for physical endurance*

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A unique formulation of ubiquinone utilizing the terpene D-limonene*

Ubiquinone helps promote cellular energy*

Also great for cardiovascular function*

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A unique endogenous compound*

Excellent choice for promoting cellular energy*

Also great for promoting general vitality*

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For Mood*

Mood is an often overlooked aspect of nootropics. This is a shame because if your mood isn’t right, it’s always going to be an uphill battle to achieve high levels of focus, motivation, cognition and overall productivity. Luckily these three premium supplements do a fantastic job of promoting a positive mood!

A very unique desert plant*

Helps promote mood by optimizing the gut-brain axis*

Also great for promoting physical vitality*

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A unique extract that mimics traditional preparations of kava*

Produces highly relaxing effects with an undercurrent of mood-brightening stimulation*

Also great for pain management*

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A unique endogenous amino acid*

Promotes mood via inhibition of glycine transporters, a very unique pathway for mood enhancement!*

Also great for promoting cognitive function*

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For Relaxation*

Sometimes all we want to do is kick our feet up and just let the world go by! These three premium supplements can quickly help you get there, allowing you to slip into a state of relaxation before you know what hit you!

A unique bark extract of the Magnolia officianalis tree*

Very relaxing but pleasantly so and not very lethargy-inducing*

Also great for promoting mood*

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An advanced extract of sage*

Produces a very uplifting sense of relaxation*

Also great for promoting cognitive function*

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A unique extract that mimics traditional preparations of kava*

Very relaxing, in a higher dose (2 grams), there is not a whole lot else besides relaxing that can be done!*

Also great for pain management, excellent for resting tired muscles at the end of the day*

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For Sleep*

Sleep is the one aspect of our daily lives that can really make or break our days. In order to have the most amount of energy, motivation and productivity during the day, it is paramount to optimize sleep quality as much as we can. There are many different strategies that can help achieve this, like proper sleep hygiene, but supplements can have a majorly beneficial impact on sleep quality too. These three premium sleep supplements are some of the best around in our opinion, and should not be missed if you wish to optimize your day!

A highly comprehensive and effective custom formulation*

Helps both induce sleep and promote sleep quality*

Includes nootropics that help promote daytime cognitive function*

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A unique supercritical CO2 extract of cracked red reishi spores*

Very high in triterpenoids*

Has a unique yet subtle sleep quality promoting effect*

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A high bioavailability formulation of zinc*

Zinc plays an important role in sleep*

Also great for promoting immune function*

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For Stress*

Have you ever sat in front of a huge pile of work and slowly started to shut down, unable to access the full potential of your brain? This effect is all too common and is soon followed by a panicky and hopeless feeling, almost like a low-level fight or flight response that certainly isn’t helping you get that work done. This phenomenon is largely attributed to stress, and it is the stress that we can actively identify. However, more often, stress runs at a low level in the background and gets in the way of daily functioning without us being entirely aware of it. Luckily, these three excellent premium stress management supplements can help provide some level of protection against stress!

Next-generation, high potency Ashwagandha extract*

Ashwagandha is a long-revered herb for supporting stress management*

Mainly attenuates stress by regulating cortisol levels*

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A high rosavin extract of Rhodiola rosea*

Great for supporting stress management, without producing an overtly calming effect*

Also great for promoting overall vitality*

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A high bioavailability formulation of Panax ginseng and Schisandra chinensis*

Contains a blend of both Panax ginseng roots and leaves, for high potency effects*

Supports stress management by regulating the function of cortisol*

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For Physical Strength*

Want to get stronger, but don’t necessarily have time to spend to get in even more exercise? Then these three premium strength supplements are exactly what you are looking for! While they won’t do the work for you, they will certainly help you get more return for the work that you do put in!

A very unique desert plant*

Helps promote T levels*

Also helps promote growth factor secretions*

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A very high potency extract of Tongkat Ali*

Helps promote T levels*

Also great for stress management and mood*

Sold out

Next-generation, high potency Ashwagandha extract*

A favorite in Ayurveda for promoting physical strength and vitality*

Also great for relaxation*

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For Recovery*

You know you got a solid workout when you are limping around the next day, but what if you didn’t have to experience this phenomenon to the same degree? Well, that’s possible with these three premium recovery supplements that help you get the most out of your workout while also making the recovery process more comfortable and shorter, allowing you to get back at it again quicker!

A high bioavailability formulation of ALA and Sesamin*

Helps attenuate muscle soreness by attenuating oxidative stress*

Also great for supporting weight loss*

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A high bioavailability formulation of the terpene Beta-caryophyllene*

Helps attenuate muscle soreness by attenuating inflammation*

Also great for pain management*

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A unique endogenous compound*

An excellent choice for addressing oxidative stress, especially in higher doses (1,000 mg/day)*

A great choice for long-term supplementation*

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For Endurance*

The thing separating us from greatness most of the time is just that extra 1%. However, that extra little bit where we need to just squeeze every last drop of performance out is oftentimes also the most critical moment. Luckily these three premium supplements can help you with that final stretch by dialing in physical endurance!

A highly revered mushroom for physical endurance*

A highly potent dual extract*

Also great for promoting general energy and mood*

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A unique endogenous compound*

Helps mitigate muscle fatigue, especially in higher doses (1,000 mg/day)*

Also great for recovery*

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A high rosavin extract of Rhodiola rosea*

Helps regulate mitophagy, a unique pathway to promoting endurance*

Also helps regulate oxidative stress, an important factor in physical endurance*

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For Blood Flow*

While blood flow supplements are traditionally catered mostly towards creating a “pump” in the gym, these three premium supplements help promote general blood circulation and blood supply to the brain. This showcases the other side of blood flow supplementation, and it can have major positive effects on our overall well being!

A unique supercritical CO2 extract of cracked Red Reishi spores*

Very high in triterpenoids*

Specifically helps promote blood flow to the brain*

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A high bioavailability formulation of ALA and Sesamin*

ALA content helps promote microcirculation*

Sesamin content helps promote blood flow*

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A high bioavailability formulation of Panax ginseng and Schisandra chinensis*

Panax ginseng content helps promote blood flow*

Schisandra chinensis content helps promote Panax ginseng absorption while also promoting blood flow itself, win-win!*

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For Oxidation*

Oxidative stress is something that constantly runs in the background, and is something we are often not consciously aware of, which we mostly have to thank our incredible endogenous defense systems for! However, these defense systems could use a helping hand every once in a while and these three premium oxidation-regulating supplements are our favorite choices!

A unique formulation of ubiquinol, utilizing the terpene D-Limonene*

Ubiqunol is the reduced form of Coenzyme Q10 and is a major endogenous oxidation regulating compound*

Also great for promoting cardiovascular function*

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A highly purified formulation of Shilajit*

Helps promote Coenzyme Q10 levels*

Also great for promoting general vitality*

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A unique endogenous compound, which is an integral part of our endogenous oxidative stress defense system*

Especially effective at higher doses (1,000 mg/day)*

A great option for long term supplementation*

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For Inflammation*

Unlike oxidation, inflammation is often something you become consciously aware of very rapidly because it results in some very noticeable changes such as stiffer joints and a foggy mind. Luckily, there are lots of supplements that can attenuate inflammation, and these three premium inflammation supplements are our favorites! 

A unique formulation of hydrogenated curcuminoids*

Highly absorbable*

Tackles inflammation from multiple different angles*

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A highly revered herb from South East Asia*

Very prominent effects on inflammation*

Also great for promoting immune function*

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A unique extract that mimics traditional preparations of kava*

Significant and wide-ranging effects on inflammation*

Also great for promoting mood and relaxation*

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For Immune Function*

There is no bigger enemy to productivity than feeling under the weather! The following three premium supplements do a fantastic job of promoting our overall immune function to help give us that extra edge!

A highly advanced immune function promoting formulation*

Contains 8 synergistic ingredients*

A comprehensive solution for daily support*

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A unique supercritical CO2 extract of cracked Red Reishi spores*

Very high in triterpenoids*

Reishi is one of the most popular mushrooms for immune function, and Lucidispore is one of the ultimate red reishi extracts!*

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A unique paraprobiotic supplement*

One of the only known supplements that is an activator of plasmacytoid dendritic cells*

Also great for promoting gut health*

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For Cardiovascular Function*

Our heart and cardiovascular system are constantly hard at work, so hard even that you can both hear and feel them doing their job! With this in mind, let’s reward our cardiovascular system for all of this hard work with these three excellent premium cardiovascular health supplements!

A unique formulation of ubiquinol, utilizing the terpene D-Limonene*

Ubiqunol is the reduced form of Coenzyme Q10 and is a major endogenous oxidation regulating compound*

Ubiquinol is a major player in the cardiovascular system, so topping up its levels may be majorly beneficial!*

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A highly bioavailable fish oil formulation*

Fish oil is one of the most popular categories of cardiovascular health supplements, and Accelon is the pinnacle of fish oil supplementation*

Also great for promoting cognitive function*

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A unique endogenous compound*

May exert a broad protective effect for our cardiovascular system*

Also great at promoting cellular health*

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For Pain Management*

If you are unlucky enough to deal with pain on a regular basis, you are likely all too familiar with all of the other aspects of your life that get affected such as your mood and cognitive function. These three premium pain management supplements help smooth out this pain enough where these secondary pain issues become much less pronounced. In fact, they even produce their own mood and cognition promoting effects, which makes this aspect of pain even less of a concern.

A high bioavailability formulation of the terpene Beta-caryophyllene*

Supports pain management by activating CB2 receptors*

Also great at addressing inflammation*

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A unique endogenous compound*

Ideal for long term supplementation (does take a few weeks to take effect)*

Tackles pain management from lots of different angles and produces a broad-spectrum effect on pain.*

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A unique extract that mimics traditional preparations of kava*

Ideal for addressing nerve-related pain*

Also great for promoting relaxation and mood*

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For Skin Health*

Healthy vibrant skin is quite the statement, it is a great observable indicator of your overall health and vitality. Thus, it is no surprise that skin health is always an extremely popular category! However, skincare is often limited to topical interventions, but this is leaving a lot of potential strategies behind. Our skin health can be very positively impacted from within too. To showcase this, we have selected our three favorite premium skin health supplements!

A unique formulation of orally bioavailable low molecular weight hyaluronic acid*

Helps promote skin firmness and suppleness*

Also great for promoting joint health*

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Next-generation, high potency Ashwagandha extract*

Stress has a major impact on skin health, and Shoden is one of the best stress management supplements around!*

Ashwagandha also helps promote healthy levels of oxidation, which is a major factor in skin health too*

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A novel formulation, specifically designed for immune function*

There is a major link between immune function and skin health, thus it is a good idea to promote immune function if you want the best possible skin health*

Anecdotal reports indicate this is a top tier supplement for promoting skin health*

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For Metabolic Health*

Oftentimes the last missing piece of the puzzle to promoting our overall health, is to optimize metabolic function. Luckily, these three premium supplements do a fantastic job at dialing in metabolic function!

A high bioavailability formulation of berberine utilizing Silymarin*

Does a great job at optimizing glucose processing*

Also great for mood*

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A high bioavailability formulation of ALA and Sesamin*

Sesamin content helps promote the metabolic effects of ALA*

Also great for promoting recovery*

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A high bioavailability formulation of the terpene Beta-caryophyllene*

Optimizes glucose processing through CB2 receptors*

Also great for pain management*

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THE BORING STUFF NOBODY READS BUT PROBABLY SHOULD

WARNING: Keep all supplements out of reach of children. Do not take any supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.

*DISCLAIMER: Always consult with a qualified health physician before taking any new dietary supplement. The products and statements found on this page are not intended to diagnose, treat, cure, or prevent any diseases. These statements have not been evaluated by the Food and Drug Administration.

SCOOPS: Nootropics Depot does not provide scoops or spoons with any of our products. Scoops are highly unreliable for accurate measuring. Scoops measure volume rather than weight which is problematic because all powders have different densities. A milligram scale is needed to accurately measure powder products.

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