About Rephyll Capsules

Rephyll delivers a standardized 6-10% beta caryophyllene extract derived from black pepper, enhanced with Zeal Technology for superior bioavailability. This naturally occurring terpene supports healthy joint function, promotes balanced inflammation levels, and helps maintain healthy blood flow throughout the body.

Our Rephyll Story

Beta caryophyllene has intrigued researchers for decades. Found abundantly in black pepper, cloves, and rosemary, this terpene was long suspected to be behind the traditional pain management benefits attributed to these botanicals. Despite promising research, beta caryophyllene's notorious volatility made it nearly impossible to harness effectively in supplement form.

We partnered with Aurea Biolabs to solve this bioavailability challenge. Their proprietary Zeal Technology encapsulates beta caryophyllene within protective lipid bilayers, creating stable liposomes that defend against degradation while promoting cellular absorption. This breakthrough delivers meaningful amounts of this valuable terpene exactly where your body needs it most.

Benefits

• Supports Natural Pain Relief: Beta caryophyllene naturally helps support the body's pain and inflammation response through its selective CB2 receptor activity, offering a plant-based approach to discomfort management without unwanted side effects.
• Supports Healthy Inflammation Response: Beta caryophyllene promotes balanced inflammation levels by modulating key inflammatory pathways, particularly benefiting those seeking natural support for exercise recovery and everyday physical stress.
• Supports Healthy Neuronal Function: Research indicates beta caryophyllene promotes cerebral blood flow and supports healthy neuronal communication, contributing to improved mental clarity and cognitive performance.
• Supports Healthy Oxidative Balance: Beta caryophyllene helps maintain cellular health by supporting the body's natural antioxidant defenses, protecting against oxidative stress that can impact overall wellness and longevity.

Rephyll's Zeal Technology delivery system maximizes these benefits through superior bioavailability, protecting the volatile beta caryophyllene molecules within lipid bilayers for enhanced cellular uptake and sustained therapeutic activity throughout the body.

Quality and Standardization

• Standardized Potency: Our Rephyll capsules are standardized to 6-10% beta caryophyllene content, verified through rigorous HPLC testing to ensure consistent therapeutic levels in every batch.
• Zeal Technology Enhancement: We utilize proprietary Zeal Technology to encapsulate beta caryophyllene within phospholipid liposomes, protecting this volatile compound from degradation and maximizing cellular absorption.
• Black Pepper Sourcing: Beta caryophyllene is carefully extracted from premium black pepper using advanced extraction methods that preserve the bioactive integrity of this delicate terpene.
• Third-Party Verification: Every batch undergoes comprehensive testing at our third-party labs for identity, purity, and potency verification with complete COA documentation available.
• Bioavailability Optimization: The lipid bilayer protection system prevents premature oxidation while facilitating targeted delivery to CB2 receptors for enhanced therapeutic efficacy.

Mechanism of Action

• CB2 Receptor Activation: Beta caryophyllene selectively binds to cannabinoid receptor 2 (CB2) throughout the body, particularly in immune cells and peripheral tissues, triggering anti-inflammatory cascades without psychoactive effects.
• Liposomal Encapsulation: Zeal Technology creates phospholipid bilayers that protect the volatile terpene molecules from degradation while facilitating cellular uptake through membrane fusion at target sites.
• Cyclooxygenase Inhibition: The compound naturally inhibits COX-2 enzyme activity, reducing prostaglandin production that contributes to inflammatory responses and associated discomfort.
• Cerebral Vasodilation: Beta caryophyllene promotes cardiovascular health by enhancing nitric oxide bioavailability, leading to improved cerebral blood flow and oxygen delivery to brain tissues.
• Nuclear Factor Modulation: The terpene influences NF-κB signaling pathways, helping regulate inflammatory gene expression while supporting the body's natural anti oxidative stress response mechanisms.

Overview of the Science

Beta caryophyllene demonstrates significant bioactive potential through its unique dual mechanism of action. Animal studies show that beta caryophyllene selectively binds to cannabinoid receptor 2 (CB2) sites throughout peripheral tissues, triggering cascade pathways that influence inflammatory mediators [1][2]. Research indicates this terpene crosses the blood-brain barrier and promotes cerebral blood circulation while modulating neuroinflammatory markers [3]. Studies suggest these combined effects may support cognitive performance and working memory function in aged subjects [4][5].

Clinical investigations demonstrate beta caryophyllene's protective effects extend to oxidative stress management and cellular health maintenance. Research shows this compound helps maintain balanced levels of inflammatory cytokines and reduces markers of DNA oxidation in brain tissue [6][7]. Studies indicate beta caryophyllene supports healthy antioxidative stress responses while promoting re-epithelialization processes in tissue repair models [8]. The compound's ability to modulate multiple pathways simultaneously makes it a promising candidate for comprehensive wellness support, particularly for those seeking blood flow supplements with additional cognitive benefits.

[1] Fidyt K et al. Cancer Med. 2016;5(10):3007-3017.

[2] Bento AF et al. Eur Neuropsychopharmacol. 2011;21(2):180-195.

[3] Paula-Freire LI et al. Eur J Pharmacol. 2012;696(1-3):56-62.

[4] Lou J et al. Front Pharmacol. 2017;8:2.

[5] Barichello T et al. Behav Brain Res. 2019;372:112012.

[6] Scandiffio R et al. Nutrients. 2020;12(11):3273.

[7] Machado KC et al. J Med Food. 2020;23(2):119-127.

[8] Gushiken LFS et al. Oxid Med Cell Longev. 2022;2022:9004014.

Ingredients

Rephyll® (Piper nigrum) Extract:

• Piper nigrum (Black Pepper) fruit extract
• 6% Beta-Caryophyllene standardization
• 500mg per serving (2 capsules)

The 6% beta-caryophyllene standardization represents a significant concentration of this bioactive sesquiterpene, which is naturally found in black pepper and acts as a selective CB2 receptor agonist. This standardization level ensures consistent potency and reliable delivery of beta-caryophyllene's unique properties, making Rephyll a dependable choice for those seeking the specific benefits of this well-researched compound.