About Rephyll Powder

Rephyll is a bioavailable beta caryophyllene supplement powered by Zeal Technology, standardized to deliver 6-10% beta caryophyllene from black pepper extract. The advanced liposomal formulation protects the volatile terpene within lipid bilayers, significantly enhancing absorption and cellular delivery. Beta caryophyllene supports joint function, promotes healthy inflammation levels, and encourages cognitive performance through improved blood flow.

Our Rephyll Story

Beta caryophyllene has fascinated researchers for its unique benefits, but bioavailability has always been the limiting factor. The volatile terpene degrades quickly and absorbs poorly, making traditional extracts ineffective at therapeutic doses. Without solving the delivery problem, beta caryophyllene would remain an underutilized compound despite its promising research profile.

We partnered with Aurea Biolabs to develop Rephyll using their proprietary Zeal Technology, which encapsulates beta caryophyllene in phospholipid liposomes. The technology protects the active compound from degradation while facilitating targeted cellular uptake. The result is a beta caryophyllene supplement that delivers meaningful benefits for joint health and repair supplements support, healthy inflammatory response, and cognitive enhancement through improved cerebral blood flow.

Benefits

• Supports Healthy Inflammatory Response: Beta caryophyllene acts as a selective cannabinoid receptor agonist, helping to balance inflammation levels throughout the body and promoting joint comfort.
• Supports Healthy Pain Management: This terpene naturally found in black pepper and cloves has been traditionally valued for discomfort relief, with research suggesting it helps support the body's natural pain response pathways.
• Supports Healthy Cognitive Function: Studies indicate beta caryophyllene positively impacts cognitive performance by influencing neuroinflammation and supporting healthy brain function through multiple pathways.
• Supports Healthy Cerebral Blood Flow: Animal research shows beta caryophyllene promotes circulation to the brain, which contributes to improved mental clarity and cognition.

Rephyll's liposomal delivery system enhances bioavailability, ensuring these benefits reach their target tissues more effectively. Standard beta caryophyllene extracts suffer from poor absorption due to the compound's volatile nature. Zeal Technology protects the active molecules within phospholipid carriers, delivering them directly to sites of action for optimal therapeutic potential across pain and inflammation pathways.

Quality and Standardization

• Standardized Beta Caryophyllene Content: Our Rephyll powder is standardized to deliver 6-10% beta caryophyllene by weight, ensuring consistent potency and reliable dosing with every serving.
• Zeal Technology Liposomal Protection: We utilize proprietary Zeal Technology to encapsulate beta caryophyllene within phospholipid bilayers, protecting this volatile terpene from degradation and maximizing bioavailability.
• Black Pepper Source Purity: Derived exclusively from high-quality black pepper extract (Piper nigrum), our beta caryophyllene is carefully extracted and purified to eliminate unwanted compounds while preserving bioactive integrity.
• Third-Party Verified Testing: Every batch undergoes comprehensive identity and purity testing at ISO-accredited third-party labs to ensure our standardization claims meet exact specifications.
• Targeted Delivery System: The liposomal formulation delivers beta caryophyllene directly to target tissues, achieving enhanced cellular absorption compared to conventional powder extracts.

Mechanism of Action

• CB2 Receptor Activation: Beta caryophyllene acts as a selective agonist of cannabinoid receptor 2 (CB2), which is primarily located in immune cells and peripheral tissues, allowing it to modulate inflammatory pathways without psychoactive effects.
• NF-κB Pathway Inhibition: This terpene suppresses the nuclear factor kappa B (NF-κB) signaling cascade, a key regulator of inflammatory gene expression, helping to reduce the production of pro-inflammatory cytokines and mediators.
• Voltage-Gated Ion Channel Modulation: Beta caryophyllene interacts with voltage-gated sodium and calcium channels in nerve cells, potentially dampening pain signal transmission and contributing to its natural analgesic properties.
• Nitric Oxide Regulation: The compound influences nitric oxide synthase activity and nitric oxide production, supporting healthy vascular function and promoting optimal blood flow supplements throughout the body.
• Antioxidant Enzyme Enhancement: Beta caryophyllene upregulates endogenous antioxidant enzymes like superoxide dismutase and catalase, helping cells neutralize reactive oxygen species and maintain healthy oxidative balance.

Overview of the Science

Beta caryophyllene demonstrates particularly promising effects on cognitive function through multiple pathways that extend beyond traditional pain and inflammation management. Research indicates that this terpene promotes cerebral blood flow while simultaneously modulating neuroinflammatory processes in the brain [1][6]. Animal studies have shown that beta caryophyllene can improve working memory performance in aged subjects, potentially through its activation of CB2 receptors and subsequent effects on cytokine production [6]. Additionally, studies examining Alzheimer's disease models suggest that beta caryophyllene may support cognitive function through PPARγ pathway activation, which plays a crucial role in neuronal health and synaptic plasticity [7].

The cardiovascular benefits of beta caryophyllene have gained attention through clinical research demonstrating its effects on vascular function. A randomized controlled trial found that inhaled beta caryophyllene significantly improved vascular stiffness parameters in human subjects, suggesting potential benefits for cardiovascular health [8]. This effect appears to be mediated through the compound's ability to support healthy endothelial function and promote optimal blood vessel elasticity. The research indicates that beta caryophyllene may help maintain healthy circulation patterns, which could contribute to both cognitive performance and overall cardiovascular wellness [8].

[1] Klauke AL et al. European Neuropsychopharmacology. 2014;24(4):608-20.

[6] Alberti TB et al. Behavioural Brain Research. 2019;372:112012.

[7] Cheng Y et al. Pharmacology. 2014;94(1-2):1-12.

[8] Yamada K et al. Experimental and Therapeutic Medicine. 2023;25(1):27.

Ingredients

Rephyll® (Piper nigrum) Extract:

• Piper nigrum fruit extract
• Standardized to 6% Beta-Caryophyllene
• 500mg per serving

The 6% beta-caryophyllene standardization ensures consistent potency of this key bioactive compound, a naturally occurring terpene found in black pepper that acts as a selective CB2 receptor agonist. This precise standardization level delivers reliable amounts of beta-caryophyllene in every serving, supporting the compound's ability to interact with the endocannabinoid system without the variability found in unstandardized pepper extracts.