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Agmatine sulfate is a biogenic compound derived from L-arginine, a common amino acid involved in the synthesis of proteins. When L-arginine undergoes decarboxylation, a process that results in the removal of a carboxylic acid, it becomes agmatine sulfate. This compound is stored in the neurons of the brain and released when those neurons are activated.
The process of creating and storing agmatine sulfate sets it apart from its amino acid counterpart. Agmatine sulfate is considered a neurotransmitter or neuromodulator. As a nootropic, agmatine sulfate offers a wide range of potential benefits to your brain health and general fitness.
Agmatine sulfate benefits may affect a wide range of systems and organs to potentially improve overall health. Agmatine sulfate’s interaction with NMDA receptors and nitric oxide have been shown to support numerous aspects of cognitive health and performance, particularly in promoting memory and learning abilities. Agmatine sulfate may also:
As a regulator of nitric oxide, agmatine sulfate may also:
Agmatine sulfate has also been shown to potentially possess powerful antioxidant properties. Part of this may come from its ability to limit glutamate activity. Overactive glutamate can actually cause over-excitation of the brain, leading to a process called excitotoxicity. Excitotoxicity leads to the elimination of nerve cells as a result of over-activation of receptors. As a potential antioxidant, agmatine sulfate may neutralize free radicals, toxins, and other harmful compounds that may damage the brain and the body..
Research shows that agmatine sulfate may also act as a calcium channel blocker, or calcium antagonist, which help to relax and widen blood vessels. This may potentially provide cardiovascular support.
Agmatine sulfate may also improve the body’s muscle mass while creating leaner, harder muscle definition.
Agmatine sulfate’s main mechanism of action involves NMDA glutamate receptors. When activated, these receptors allow for a flow of positively charged ions through the cell membrane. NMDA receptors are also one of the key glutamate receptors involved in regulating memory functions and synaptic plasticity. Synaptic plasticity describes the ability for signals between nerves to grow or weaken over time. The stronger these signals are, the more effectively the neurons can communicate.
Agmatine sulfate has also been shown to control levels of nitric oxide. Nitric oxide is a compound naturally produced in your body that plays a role in cell signaling and communication throughout your entire system.
As a dietary supplement, take 500mg of Agmatine sulfate once daily.
To learn more, read the Agmatine sulfate reviews and experiences below.
Nootropics Depot offers 125g or 250g jars of high quality Agmatine sulfate powder. Nootropics Depot's Agmatine sulfate has been lab-tested and verified for both product purity and identity.
You may also like Agmatine sulfate capsules.
Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated, by the FDA.
I originally bought this to try to treat bipolar depressive symptoms. It had almost no effect for that, but it did relieve a small amount of anxioudness. Instead of relieving my depressive symptoms, it bulked my muscles up to near the size they were when I was heavy into bodybuilding, without me having to exercise at all. Must be a muscle memory effect. Also, my appetite went out of control.
Where it really shined was that it was the first effective supplement I found to prevent my mother's seizures. It also helped with her depressive symptoms more than mine, but she doesn't have BPD. It helped her with pain relief to a mild degree. Jason on 25th Feb 2019
This substance has glowing reviews, but I haven't got any benefit. It's hard to tell if it really does something. Unknown on 16th Jan 2019
I'm very satisfied with your brand and business ... I take agmatine about 750mg once and it looks like l arginine, for a more comprehensive answer I need more time and full usage. Mario on 1st Oct 2018
Highly recommended ++++++ Unknown on 27th Aug 2018
Good quality product. Works well to maintain tolerances to other substances. By itself, it brings you more into the moment, which helps with concentration. Unknown on 20th Jul 2018
Hi I am very new to nootropics and I am really still Experimenting with these . I have not found the right thing yet . I felt like agmatine Did help me to go to sleep a couple nights. I took 750 mg. I have also been taking phenylpiracetam and adrafinil and noopept along with choline The Choline I purchased at the health food store. Sometimes it makes me feel like I’m actually tired from taking it so maybe I just don’t know what I’m doing but I think they are probably very good products and I’m going to keep Trying. TERESA on 5th Apr 2018
Purchased Agmatine as a supplement to potentially increase vasodilation, but found that it was having other effects within two weeks of of starting a one gram b.i.d. regimen:
°Greatly improved sleep architecture.
°Mild to moderate stress support
°Mild to moderate pain support
°A very welcome mild cardiovascular effect
All in all an awesome product that will always be present in my supplemental regimen.
Scott H., LVN Scott H., LVN on 4th Apr 2018
Great stacker with other nootropics. This one didn't make feel nauseous but rather more clarity of my surroundings. Trevor on 2nd Feb 2018
Great for all physical activities, gives a great push. Barak on 5th Jan 2018
When exercising (kick-boxing physical training) this helps with focus and muscle strength.
This is my experience. My first purchase at this site.
Good product. Thanks!
Regards. Unknown on 25th Dec 2017