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100% Vegan Lactose Free Gluten Free GMO Free
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100% Vegan Lactose Free Gluten Free GMO Free

4’-DMA-7,8-DHF Capsules | 4'-DMA-7,8-Dihydroxyflavone | Eutropoflavin

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label-lactose-free:
true
label-gluten-free:
true
label-gmo-free:
true
label-vegan:
true
label-vegetarian:
true
info-dose:
10mg (One Capsule)
info-dose-timing:
Morning
info-dose-frequency:
1-2 Times Daily
info-how-to-take:
With Or Without Food
benefits-effect-days:
1-2 Weeks (With Immediate Effects)
Benefits:
Cognition
Benefits:
Memory
Benefits:
Mood
Benefits:
Neuroprotection
product-summary:
  • Supports Cognitive Function
  • Improves Memory Function
  • Supports Positive Mood
  • Enhances Neuroprotection
page-fact-checked:
false
research-snapshot-summary:
4’-DMA-7,8-DHF is a nootropic derived from 7,8-Dihydroxyflavone, formulated to enhance cognitive function, improve memory retention, support neuroprotection, and offer potential antidepressant effects, making it a versatile compound for brain health.
Dietary Restrictions:
Lactose Free
Dietary Restrictions:
Gluten Free
Dietary Restrictions:
Non-GMO
Dietary Restrictions:
Vegan
Dietary Restrictions:
Vegetarian
Type:
Capsules
Type:
Flavanoids
Type:
Nootropics
disable-paypal:
false
lab-testing:
DHF4CS1042924A | DHF4CS1042924A_caps_90ct_Signed.pdf
lab-testing:
DHF4CS1061724 | DHF4CS1061724_caps_90ct_Signed.pdf
lab-testing:
DHF4CS1071024 | DHF4CS1071024_caps_30ct_Signed.pdf
lab-testing:
DHF4CS1072524A | DHF4CS1072524A_caps_30ct_Signed.pdf
lab-testing:
DHF4CS1111023 | DHF4CS1111023_caps_90ct_signed.pdf
lab-testing:
DHF4CS1112423 | DHF4CS1112423_caps_30ct_signed.pdf
lab-testing:
DHF4CS1011124A | DHF4CS1011124A_caps_30ct_signed.pdf
lab-testing:
DHF4CS1011524A | DHF4CS1011524A_caps_90ct_Signed.pdf
lab-testing:
DHF4CS1031124 | DHF4CS1031124_caps_90ct_signed.pdf
lab-testing:
DHF4CS1052324 | DHF4CS1052324_caps_30ct_Signed.pdf
lab-testing:
DHF4CS1081624 | DHF4CS1081624_30ct_Signed.pdf
lab-testing:
DHF4CS1080724 | DHF4CS1080724_90ct_Signed.pdf
$29.99
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Product Usage

Dose Dose

10mg (One Capsule)

Dose Timing Dose Timing

Morning

How to Take How to Take

With Or Without Food

Dose Frequency Dose Frequency

1-2 Times Daily

Summary

4’-DMA-7,8-DHF is a nootropic derived from 7,8-Dihydroxyflavone, formulated to enhance cognitive function, improve memory retention, support neuroprotection, and offer potential antidepressant effects, making it a versatile compound for brain health.

Benefits

Time to notice full effects: 1-2 Weeks (With Immediate Effects)

  • Cognition Cognition
  • Memory Memory
  • Mood Mood
  • Neuroprotection Neuroprotection

What Are 4’-DMA-7,8-DHF Capsules?

4'-Dimethylamino 7,8 Dihydroxyflavone (4’-DMA-7,8-DHF) is a nootropic compound derivative of the naturally occurring flavone 7,8 Dihydroxyflavone (7,8 DHF). 4’-DMA-7,8-DHF differs from 7,8-DHF by the addition of a dimethylamino group off the 4 position on the flavone base structure. A dimethyl amino group consists of a nitrogen atom with two methyl groups.

Chemical Properties of 4’-DMA-7,8-DHF

4’-DMA-7,8-DHF is slightly water soluble and also slightly lipid soluble, this is derived from the cLogP value of 4’-DMA-7,8-DHF, which is 2.28. This means that 4’-DMA-7,8-DHF can readily transition from the aqueous phase to the lipid phase. Below is an in depth description of 4’-DMA-7,8-DHF chemical properties: 

Molecular formula: C17H15NO4

Molecular weight: 297.31 g/mol

Number of Heavy Atoms: 22

Number of aromatic heavy atoms: 16

Fraction of SP3 Carbon: 0.12 

Number of rotatable bonds: 2

Number of hydrogen bond acceptors: 4

Number of hydrogen bond donors: 2

Molar refractivity: 86.17

Topological polar surface area: 73.91 square Angstrom

CAS: 1205548-04-4

IUPAC: 2-[4'-(dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one

What Is The Difference Between 7,8 DHF and 4’-DMA-7,8-DHF?

4’-DMA-7,8-DHF shares the same chemical structure as 7,8 DHF, but with the addition of a dimethylamino group at the 4 position off the flavone base structure. The dimethylamino significantly changes a few key chemical properties of 7,8 DHF, of particular note are:

Number of heavy atoms (4’-DMA-7,8-DHF gains 3 heavy atoms)

  • 7,8 DHF: 19

  • 4’-DMA-7,8-DHF: 22

Fraction of SP3 Carbon (difference of 0.12) 

  • 7,8 DHF: 0.00

  • 4’-DMA-7,8-DHF: 0.12

Rotatable bond (4’-DMA-7,8-DHF gains 1 additional rotatable bond)

  • 7,8 DHF: 1 rotatable bond

  • 4’-DMA-7,8-DHF: 2 rotatable bonds

Molar refractivity (difference of 14.2)

  • 7,8 DHF: 71.97

  • 4’-DMA-7,8-DHF: 86.17

The rest of the chemical properties stay largely unchanged, for example, 7,8 DHF and 4’-DMA-7,8-DHF have the same amount of aromatic heavy atoms, hydrogen bond donors and hydrogen bond acceptors. Their cLogP’s are also very similar (7,8 DHF: 2.35 vs 4’-DMA-7,8-DHF: 2.28), thereby indicating that 7,8 DHF and 4’-DMA-7,8-DHF are going to largely have the same water and lipid soluble properties. Their topological polar surface area is also very similar, and only differs by 3.24 square Angstrom (7,8 DHF: 70.67 vs 4’-DMA-7,8-DHF: 73.91).

4’-DMA-7,8-DHF Reviews

To gain more insight, see the 4’-DMA-7,8-DHF reviews and experiences below.

Where to Buy 4’-DMA-7,8-DHF Capsules

Nootropics Depot offers 30ct. or 90ct. jars of 4’-DMA-7,8-DHF capsules. Nootropics Depot's 4’-DMA-7,8-DHF capsules have been lab-tested and verified for both product purity and identity.

 *Attention: All chemical compounds have risks. Please read the available research and understand the associated risks before handling. If you are uncertain of the appropriate handling methods, please consult a qualified professional. Misuse of this product may result in adverse reactions. This product is not approved by the FDA.

Reviews

  • 5
    wow

    Posted by T Greer on 13th Jul 2023

    This is my limitless supplement, I tried taking it orally, and it had a mild effect, then I put it under my tounge, wow! I can feel it kick in, the first time I did this, I felt it within a few min. It helps be focus, and makes my interactions with people easy peasy, usually I avoid people, but with this stuff I don't worry about social stress, its not a thing anymore and the effect lasts after not taking it. I take it 3 days on two days off, I do this with most all nootropics. they last longer that way. Also it lasts me all day, it pairs well, with Sabroxy and Cognance.

  • 5
    Very efficient compound

    Posted by Claude-Marie Bacquere on 13th Jun 2023

    It is an efficient and potent compound. Eutropoflavin has an elevating effect on mood and on neuroplasticity (focus and memory). Focus wise, it feels a bit more mood-elevating with effects (I'm not a medical doctor, it is only anecdotal). It works a very long time, with a very long half-life, so be sure to take it early in the morning or it may disrupt your sleep (I take it at 6 AM before work). Being potent, it may have adverse effects on some people (my girlfriend experienced mild nausea. Some people experiences small headaches). It may be one of the most potent and efficient Nootropics I've tried, a compound which really amazes me, but as most very efficient nootropics, be responsible : don't take too much of it (1 cap is fine) and don't stack it with a lot of things if you don't know what you are doing.

  • 5
    The Fountain of Youth

    Posted by Jason White on 2nd Jun 2023

    This is amazing, I'm normally lethargic, but I really get moving on this stuff. Take it in the morning, and an hour later you are ready to tackle everything thrown at you for the next 4 hours or so. The research is very interesting.

  • 5
    Expensive but 100% worth it

    Posted by Juan Serrano on 27th Nov 2022

    I can't recommend this nootropic enough. This nootropic WORKS and it works immediately. If you take one capsule sublingually, in the next minutes you will feel an improvement in mood and focus and a reduction in stress. If you're like me, the effect is very notable.

  • 4
    my only complaint is the capsules, make this powder or something for sublingual

    Posted by William Simpson on 2nd Nov 2022

    I love this stuff. I can feel it kicking in. I take it first thing in the morning sublingually because I understand that the long duration might disrupt sleep. I also believe that increased bdnf can mitigate sleep disruption so that I feel like I need less sleep when I feel like my bdnf levels are high I do think it slightly disrupts my sleep but that I aclimated to it over a couple weeks. I like to take breaks on the weekend but I'm thinking I might take this one every day going sometime soon. My mood and mental flexibility feels improved similar to other bdnf enhancing activities, but more so than most others. I think there's a libido increase too with this one. I wish they'd offer this as a powder or in since other form that better facilitates sublingual administration. The gel cap takes some time to dissolve and I'm trying to get this stuff into my brain ASAP so it can be metabolized by bedtime. This is maybe my favorite supplement next to polygala and lion's mane. I used to exercise hard every day to get my depressed brain out of is funk for an hour or two but with all of these bdnf enhancing supplements I feel that 'anything's possible' buzz all day long.

  • 5
    Effective, noticeable over time

    Posted by Mark Parker on 10th Jun 2022

    Takes a couple weeks of chronic use to make a noticeable difference. Stick with it to reap the benefits. Sleep may be affected initially, but the positive results starting kicking in over time. Taking it sublingually seems to be helpful for me. Mixing the powder in with some Calcium AKG seems to result in a pretty powerful antidepressant effect. Increased productivity, energy and optimism seems to be the result for me.

  • 5
    4'-DMA-7,8-DMF

    Posted by Edward Koenig on 30th Mar 2022

    My wife and I are elderly and each takes 2 capsules of 4'-DMA-7,8-DHF, as a daily dietary supplement. Based on evidence from scientific studies, the supplement has beneficial properties related to brain function. One important property relates to memory formation. Memory formation, involving “synaptic plasticity” is defined as dynamic changes in structure of synapses and synaptic connections in a brain region mediating memory formation. An important mediator of synaptic plasticity in brain is a small protein, called Brain-Derived Neurotrophic Factor (BDNF). BDNF is secreted within brain and is not taken up readily from blood. BDNF interacts (binds) with an enzyme receptor to produce ultimate synaptic plasticity effects. Interestingly, the enzyme can be activated by a naturally occurring small plant molecule called 7,8 dihydroxyflavone (DHF), which, when given orally, can reach brain tissue. Nonetheless, blood borne DHF is largely eliminated by liver, so less becomes available for take-up in the brain. A synthetically modified DHF is 4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF), which also readily reaches brain tissue and has longer action duration.

  • 5
    Easily one of my favorites

    Posted by Daniel on 21st Mar 2022

    This is a great product, I'm surprised to see such mixed reviews but I know everyone's chemistry is different. I really feel significant difference in my energy and awareness when i take this vs. when I do not. Once in awhile I'll take two capsules early in the morning when I'm swamped at work with great results (I don't recommend doing this regularly though). I believe it has a long half-life, so it's best to take early to avoid sleep interactions. It's on the pricey side but I recommend giving it a try.

  • 5
    4'-DA 7,8-DHF

    Posted by EK on 9th Mar 2022

    My wife and I are elderly and take 4'-DMA-7,8-DHF, as a daily dietary supplement. Why do we take the supplement? Based on evidence from scientific studies, the supplement has beneficial properties related to brain function. One important property relates to memory formation. Memory formation, involving “synaptic plasticity” is defined as dynamic changes in structure of synapses and synaptic connections in a brain region mediating memory formation. An important mediator of synaptic plasticity in brain is a small protein, called Brain-Derived Neurotrophic Factor (BDNF). BDNF is secreted within brain and is not taken up readily from the blood. BDNF interacts with an enzyme receptor to produce ultimate synaptic plasticity effects. Interestingly, the enzyme can be activated by a naturally occurring plant molecule called 7,8 dihydroxyflavone (DHF), which, when given orally, can reach brain tissue. Nonetheless, blood borne DHF is largely eliminated by liver so less becomes available for take-up in the brain. A synthetically modified DHF is 4'-Dimethylamino-7,8-dihydroxyflavone (4'-DMA-7,8-DHF), which has more potent and longer action duration.

  • 3
    Slight Effect

    Posted by Martin Hayes on 29th Jan 2022

    Decent at the start wears off quick.

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*Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.