4'-Dimethylamino 7,8 Dihydroxyflavone (4’-DMA-7,8-DHF) is a nootropic compound derivative of the naturally occurring flavone 7,8 Dihydroxyflavone (7,8 DHF). 4’-DMA-7,8-DHF differs from 7,8-DHF by the addition of a dimethylamino group off the 4 position on the flavone base structure. A dimethyl amino group consists of a nitrogen atom with two methyl groups.
4’-DMA-7,8-DHF is slightly water soluble and also slightly lipid soluble, this is derived from the cLogP value of 4’-DMA-7,8-DHF, which is 2.28. This means that 4’-DMA-7,8-DHF can readily transition from the aqueous phase to the lipid phase. Below is an in depth description of 4’-DMA-7,8-DHF chemical properties:
Molecular formula: C17H15NO4
Molecular weight: 297.31 g/mol
Number of Heavy Atoms: 22
Number of aromatic heavy atoms: 16
Fraction of SP3 Carbon: 0.12
Number of rotatable bonds: 2
Number of hydrogen bond acceptors: 4
Number of hydrogen bond donors: 2
Molar refractivity: 86.17
Topological polar surface area: 73.91 square Angstrom
CAS: 1205548-04-4
IUPAC: 2-[4'-(dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one
4’-DMA-7,8-DHF shares the same chemical structure as 7,8 DHF, but with the addition of a dimethylamino group at the 4 position off the flavone base structure. The dimethylamino significantly changes a few key chemical properties of 7,8 DHF, of particular note are:
Number of heavy atoms (4’-DMA-7,8-DHF gains 3 heavy atoms)
7,8 DHF: 19
4’-DMA-7,8-DHF: 22
Fraction of SP3 Carbon (difference of 0.12)
7,8 DHF: 0.00
4’-DMA-7,8-DHF: 0.12
Rotatable bond (4’-DMA-7,8-DHF gains 1 additional rotatable bond)
7,8 DHF: 1 rotatable bond
4’-DMA-7,8-DHF: 2 rotatable bonds
Molar refractivity (difference of 14.2)
7,8 DHF: 71.97
4’-DMA-7,8-DHF: 86.17
The rest of the chemical properties stay largely unchanged, for example, 7,8 DHF and 4’-DMA-7,8-DHF have the same amount of aromatic heavy atoms, hydrogen bond donors and hydrogen bond acceptors. Their cLogP’s are also very similar (7,8 DHF: 2.35 vs 4’-DMA-7,8-DHF: 2.28), thereby indicating that 7,8 DHF and 4’-DMA-7,8-DHF are going to largely have the same water and lipid soluble properties. Their topological polar surface area is also very similar, and only differs by 3.24 square Angstrom (7,8 DHF: 70.67 vs 4’-DMA-7,8-DHF: 73.91).
To gain more insight, see the 4’-DMA-7,8-DHF reviews and experiences below.
Nootropics Depot offers 30ct. or 90ct. jars of 4’-DMA-7,8-DHF capsules. Nootropics Depot's 4’-DMA-7,8-DHF capsules have been lab-tested and verified for both product purity and identity.
| *Attention: All chemical compounds have risks. Please read the available research and understand the associated risks before handling. If you are uncertain of the appropriate handling methods, please consult a qualified professional. Misuse of this product may result in adverse reactions. This product is not approved by the FDA. |
This nootropic is definitely subtle. I’ve decided to keep it in the rotation as I feel like I felt sharper and less run down after long work weeks. The effect is more noticeable in looking at what’s no longer present during burnout days than looking for active effects.
I cannot begin to say enough about this nootropic. Since not a lot is known about long-term use, I only take it once a week but each time I take it it is my favorite day of the week by far. Music sounds better, my mood boost, I am very talkative while at the same time able to be focused and concentrate on whatever I want. I advise not taking it after 7 AM because it lasts all day and all night. More research is needed, because its effects are profound.
This nootropic is definitely subtle. I’ve decided to keep it in the rotation as I feel like I felt sharper and less run down after long work weeks. The effect is more noticeable in looking at what’s no longer present during burnout days than looking for active effects.
I cannot begin to say enough about this nootropic. Since not a lot is known about long-term use, I only take it once a week but each time I take it it is my favorite day of the week by far. Music sounds better, my mood boost, I am very talkative while at the same time able to be focused and concentrate on whatever I want. I advise not taking it after 7 AM because it lasts all day and all night. More research is needed, because its effects are profound.
I used this in a stack with Noopept, L-tyrosine, and piracetam. It's a softer pull than the Aniracetam push. I think it may shine brightest next to Noopept alone.
Cost me just under $100. Took them regularly, in the dosage I found online, since the morning after I received them. Can honestly say I didn't feel not one single effect or difference from them, nothing at all. The only thing "different" in my body or mind after starting taking them was some mild kidney pain. That seemed to stop after about ten days, didn't notice it beyond that. Either way, can't say I recommend it. Unless you're an individual who knows that they are personally quite prone to experiencing placebo effects.
I tried this supplement for the first time about 6 weeks ago. I have never taken Tropoflavin before, just jumped on over to Eutropoflavin. One pill in the morning or early afternoon is just enough to provide mental energy and motivation to stay awake and get things done. I have even observed a subtle, but noticable, improvement in my short-term memory. As someone with ongoing issues with mental and physical exhaustion/fatigue, I found this supplement to be helpful while not overpowering like a stimulant. I did try taking 2 pills in 1 day, hours apart, and noticed some odd tingling in my feet. However, I can't say for sure this was due to the Eutropoflavin. I probably didn't need to try 2 since 1 is just enough and the form is easily bioavailable. Recommended for those needing a mental boost without the negative side effects of a stimulant.
The first time I took a half dose and didn't feel anything. The next time I took a full capsule and felt good but nothing too noticeable. The third time i took a full dose I felt weird/off somehow. Hard to explain. I'm not sure if I"m supposed to take with food or on an empty stomach. My husband gets a good mood boost and more motivation when he takes it.
Good supplement, not easy to find from other suppliers, backed by research, seems effective.
A few months ago I had finally decided to try the original 7,8-DHF, and I was pleasantly surprised by the results. So after doing my research, and finding out that this version was a more bioavailable, way longer lasting, annnnd more potent version, I was definitely on board to try it out. On the very first day I took two 8mg capsules and wow, as advertised it quickly became apparent that this version was more powerful. I got a strong mood lift and sense of well-being, as well as a feeling of not really so much energized, but motivation to carry out my daily tasks. What I really liked about 4 DMA was that it lasted from when I took it in the morning to well into the late afternoon. After two weeks of the same dose of two capsules in the morning, I found that the effects were still present in a consistent manner. Of course I felt a tad bit of reduction in potency after 2 weeks but not as much as you’d think. I personally love this supplement, and I’ll be ordering another bottle for sure.
Anyone that says that they feel better, take that info with a grain of salt. All theory. I love science, but to rate it is somewhat hard to do at this point.
Mood Brightner, Nootropic, Anxiolytic, ...even has drops my blood pressure (as I'm hypertensive) & even an Analgesic quality to it. It is in addition to an Escitalopram/Mirtazapine, so there is probably a "many streams to large river" synergistic effect going on. This stuff is amazing. I just wish I knew more about its Pharmacokinetics so I could dose accordingly; flavonoids are relatively non-toxic, not particularly worried about toxicity. Do I cycle?...or take every day? ... etc. Lovely compound -- give it a shot! If I was wealthy, I would have all my family & friends include this in their dietary regimen -- even if it is the only supplement they'll ever take.
I am 35, 5'11, male. I take one 4'DMA capsule in the morning and I definitely notice the effects; they are not subtle in the way that regular 7-8 DHF is. I take 60mg of adderall every day, but I do not need it when I take these. - Improved mood - Improved focus - Improved energy - Lasts 5-6 hours (YMMV) - Hair falling out faster than normal (BDNF effects. Attempting to mitigate with NAC.) - Beard and other hair growing faster than normal (strange dichotomy) I do not know the ideal dosing schedule for this noot, so I am only taking it a couple times a week, one capsule. --- Sidenote: As of this writing, there is only one other review, five stars that says "As of now, I've felt no immediate effects that I can detect, yet these flavanoids are known to need to build up in the body, as well as not inherently having effects you can feel but may be supporting neuron survival/proliferation." This is the opposite of my experience, but moreover why the hell are you writing a five-star review if you're not noticing any effects? Totally dilutes the quality of reviews on ND.
As NootropicsDepot only has the purest compounds I am always eager to test their products. I have been taking this for a week. Anywhere from 1 to 2 capsules in the monring, sometimes 3 at breakfast, lunch, and dinner. As of now, I've felt no immediate effects that I can detect, yet these flavanoids are known to need to build up in the body, as well as not inherently having effects you can feel but may be supporting neuron survival/proliferation. Will update if anything surprising shows up! As always thanks to NootropicsDepot for providing access to such interesting substances at the highest purity!
