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4’-DMA-7,8-DHF Capsules | 10mg | 4'-DMA-7,8-Dihydroxyflavone | Eutropoflavin

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$29.99 - $74.99

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4’-DMA-7,8-DHF Capsules | 10mg |  4'-DMA-7,8-Dihydroxyflavone | Eutropoflavin
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Description

What Are 4’-DMA-7,8-DHF Capsules?

4'-Dimethylamino 7,8 Dihydroxyflavone (4’-DMA-7,8-DHF) is a nootropic compound derivative of the naturally occurring flavone 7,8 Dihydroxyflavone (7,8 DHF). 4’-DMA-7,8-DHF differs from 7,8-DHF by the addition of a dimethylamino group off the 4 position on the flavone base structure. A dimethyl amino group consists of a nitrogen atom with two methyl groups.

Chemical Properties of 4’-DMA-7,8-DHF

4’-DMA-7,8-DHF is slightly water soluble and also slightly lipid soluble, this is derived from the cLogP value of 4’-DMA-7,8-DHF, which is 2.28. This means that 4’-DMA-7,8-DHF can readily transition from the aqueous phase to the lipid phase. Below is an in depth description of 4’-DMA-7,8-DHF chemical properties: 

Molecular formula: C17H15NO4

Molecular weight: 297.31 g/mol

Number of Heavy Atoms: 22

Number of aromatic heavy atoms: 16

Fraction of SP3 Carbon: 0.12 

Number of rotatable bonds: 2

Number of hydrogen bond acceptors: 4

Number of hydrogen bond donors: 2

Molar refractivity: 86.17

Topological polar surface area: 73.91 square Angstrom

CAS: 1205548-04-4

IUPAC: 2-[4'-(dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one

What Is The Difference Between 7,8 DHF and 4’-DMA-7,8-DHF?

4’-DMA-7,8-DHF shares the same chemical structure as 7,8 DHF, but with the addition of a dimethylamino group at the 4 position off the flavone base structure. The dimethylamino significantly changes a few key chemical properties of 7,8 DHF, of particular note are:

Number of heavy atoms (4’-DMA-7,8-DHF gains 3 heavy atoms)

  • 7,8 DHF: 19

  • 4’-DMA-7,8-DHF: 22

Fraction of SP3 Carbon (difference of 0.12) 

  • 7,8 DHF: 0.00

  • 4’-DMA-7,8-DHF: 0.12

Rotatable bond (4’-DMA-7,8-DHF gains 1 additional rotatable bond)

  • 7,8 DHF: 1 rotatable bond

  • 4’-DMA-7,8-DHF: 2 rotatable bonds

Molar refractivity (difference of 14.2)

  • 7,8 DHF: 71.97

  • 4’-DMA-7,8-DHF: 86.17

The rest of the chemical properties stay largely unchanged, for example, 7,8 DHF and 4’-DMA-7,8-DHF have the same amount of aromatic heavy atoms, hydrogen bond donors and hydrogen bond acceptors. Their cLogP’s are also very similar (7,8 DHF: 2.35 vs 4’-DMA-7,8-DHF: 2.28), thereby indicating that 7,8 DHF and 4’-DMA-7,8-DHF are going to largely have the same water and lipid soluble properties. Their topological polar surface area is also very similar, and only differs by 3.24 square Angstrom (7,8 DHF: 70.67 vs 4’-DMA-7,8-DHF: 73.91).

Where to Buy 4’-DMA-7,8-DHF Capsules

Nootropics Depot offers 30ct. or 90ct. jars of 4’-DMA-7,8-DHF capsules. Nootropics Depot's 4’-DMA-7,8-DHF capsules have been lab-tested and verified for both product purity and identity.

Attention: All chemical compounds have risks. Please read the available research and understand the associated risks before handling. If you are uncertain of the appropriate handling methods, please consult a qualified professional. Misuse of this product may result in adverse reactions. This product is not approved by the FDA.

26 Reviews

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  • DRAS - 28th Mar 2021

    5
    Good Nootopic

    Good supplement, not easy to find from other suppliers, backed by research, seems effective.

  • JMac - 25th Feb 2021

    5
    Exceeded expectations

    A few months ago I had finally decided to try the original 7,8-DHF, and I was pleasantly surprised by the results. So after doing my research, and finding out that this version was a more bioavailable, way longer lasting, annnnd more potent version, I was definitely on board to try it out. On the very first day I took two 8mg capsules and wow, as advertised it quickly became apparent that this version was more powerful. I got a strong mood lift and sense of well-being, as well as a feeling of not really so much energized, but motivation to carry out my daily tasks. What I really liked about 4 DMA was that it lasted from when I took it in the morning to well into the late afternoon. After two weeks of the same dose of two capsules in the morning, I found that the effects were still present in a consistent manner. Of course I felt a tad bit of reduction in potency after 2 weeks but not as much as you’d think. I personally love this supplement, and I’ll be ordering another bottle for sure.

26 Reviews

  • DRAS - 28th Mar 2021

    5
    Good Nootopic

    Good supplement, not easy to find from other suppliers, backed by research, seems effective.

  • JMac - 25th Feb 2021

    5
    Exceeded expectations

    A few months ago I had finally decided to try the original 7,8-DHF, and I was pleasantly surprised by the results. So after doing my research, and finding out that this version was a more bioavailable, way longer lasting, annnnd more potent version, I was definitely on board to try it out. On the very first day I took two 8mg capsules and wow, as advertised it quickly became apparent that this version was more powerful. I got a strong mood lift and sense of well-being, as well as a feeling of not really so much energized, but motivation to carry out my daily tasks. What I really liked about 4 DMA was that it lasted from when I took it in the morning to well into the late afternoon. After two weeks of the same dose of two capsules in the morning, I found that the effects were still present in a consistent manner. Of course I felt a tad bit of reduction in potency after 2 weeks but not as much as you’d think. I personally love this supplement, and I’ll be ordering another bottle for sure.

  • Dre - 11th Feb 2021

    3
    Reviewing something you can't feel

    Anyone that says that they feel better, take that info with a grain of salt. All theory. I love science, but to rate it is somewhat hard to do at this point.

  • Scott - 11th Feb 2021

    5
    LVN's review of "NeoDrox" (Eutropoflavin)

    Mood Brightner, Nootropic, Anxiolytic, ...even has drops my blood pressure (as I'm hypertensive) & even an Analgesic quality to it. It is in addition to an Escitalopram/Mirtazapine, so there is probably a "many streams to large river" synergistic effect going on. This stuff is amazing. I just wish I knew more about its Pharmacokinetics so I could dose accordingly; flavonoids are relatively non-toxic, not particularly worried about toxicity. Do I cycle?...or take every day? ... etc. Lovely compound -- give it a shot! If I was wealthy, I would have all my family & friends include this in their dietary regimen -- even if it is the only supplement they'll ever take.

  • Alex R - 4th Feb 2021

    5
    Pretty great new nootropic

    I am 35, 5'11, male. I take one 4'DMA capsule in the morning and I definitely notice the effects; they are not subtle in the way that regular 7-8 DHF is. I take 60mg of adderall every day, but I do not need it when I take these. - Improved mood - Improved focus - Improved energy - Lasts 5-6 hours (YMMV) - Hair falling out faster than normal (BDNF effects. Attempting to mitigate with NAC.) - Beard and other hair growing faster than normal (strange dichotomy) I do not know the ideal dosing schedule for this noot, so I am only taking it a couple times a week, one capsule. --- Sidenote: As of this writing, there is only one other review, five stars that says "As of now, I've felt no immediate effects that I can detect, yet these flavanoids are known to need to build up in the body, as well as not inherently having effects you can feel but may be supporting neuron survival/proliferation." This is the opposite of my experience, but moreover why the hell are you writing a five-star review if you're not noticing any effects? Totally dilutes the quality of reviews on ND.

  • Alexander Shultheis - 31st Jan 2021

    5
    Waiting for Effects to Manifest

    As NootropicsDepot only has the purest compounds I am always eager to test their products. I have been taking this for a week. Anywhere from 1 to 2 capsules in the monring, sometimes 3 at breakfast, lunch, and dinner. As of now, I've felt no immediate effects that I can detect, yet these flavanoids are known to need to build up in the body, as well as not inherently having effects you can feel but may be supporting neuron survival/proliferation. Will update if anything surprising shows up! As always thanks to NootropicsDepot for providing access to such interesting substances at the highest purity!

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