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100% Vegan Lactose Free Gluten Free GMO Free
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100% Vegan Lactose Free Gluten Free GMO Free

4’-DMA-7,8-DHF Capsules | 4'-DMA-7,8-Dihydroxyflavone | Eutropoflavin

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label-lactose-free:
true
label-gluten-free:
true
label-gmo-free:
true
label-vegan:
true
label-vegetarian:
true
info-dose:
10mg (One Capsule)
info-dose-timing:
Morning
info-dose-frequency:
1-2 Times Daily
info-how-to-take:
With Or Without Food
benefits-effect-days:
1-2 Weeks (With Immediate Effects)
Benefits:
Cognition
Benefits:
Memory
Benefits:
Mood
Benefits:
Neuroprotection
product-summary:
  • Supports Cognitive Function
  • Improves Memory Function
  • Supports Positive Mood
  • Enhances Neuroprotection
page-fact-checked:
false
research-snapshot-summary:
4’-DMA-7,8-DHF is a nootropic derived from 7,8-Dihydroxyflavone, formulated to enhance cognitive function, improve memory retention, support neuroprotection, and offer potential antidepressant effects, making it a versatile compound for brain health.
Dietary Restrictions:
Lactose Free
Dietary Restrictions:
Gluten Free
Dietary Restrictions:
Non-GMO
Dietary Restrictions:
Vegan
Dietary Restrictions:
Vegetarian
Type:
Capsules
Type:
Flavanoids
Type:
Nootropics
disable-paypal:
false
lab-testing:
DHF4CS1042924A | DHF4CS1042924A_caps_90ct_Signed.pdf
lab-testing:
DHF4CS1061724 | DHF4CS1061724_caps_90ct_Signed.pdf
lab-testing:
DHF4CS1071024 | DHF4CS1071024_caps_30ct_Signed.pdf
lab-testing:
DHF4CS1072524A | DHF4CS1072524A_caps_30ct_Signed.pdf
lab-testing:
DHF4CS1111023 | DHF4CS1111023_caps_90ct_signed.pdf
lab-testing:
DHF4CS1112423 | DHF4CS1112423_caps_30ct_signed.pdf
lab-testing:
DHF4CS1011124A | DHF4CS1011124A_caps_30ct_signed.pdf
lab-testing:
DHF4CS1011524A | DHF4CS1011524A_caps_90ct_Signed.pdf
lab-testing:
DHF4CS1031124 | DHF4CS1031124_caps_90ct_signed.pdf
lab-testing:
DHF4CS1052324 | DHF4CS1052324_caps_30ct_Signed.pdf
lab-testing:
DHF4CS1081624 | DHF4CS1081624_30ct_Signed.pdf
lab-testing:
DHF4CS1080724 | DHF4CS1080724_90ct_Signed.pdf
$29.99
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Product Usage

Dose Dose

10mg (One Capsule)

Dose Timing Dose Timing

Morning

How to Take How to Take

With Or Without Food

Dose Frequency Dose Frequency

1-2 Times Daily

Summary

4’-DMA-7,8-DHF is a nootropic derived from 7,8-Dihydroxyflavone, formulated to enhance cognitive function, improve memory retention, support neuroprotection, and offer potential antidepressant effects, making it a versatile compound for brain health.

Benefits

Time to notice full effects: 1-2 Weeks (With Immediate Effects)

  • Cognition Cognition
  • Memory Memory
  • Mood Mood
  • Neuroprotection Neuroprotection

What Are 4’-DMA-7,8-DHF Capsules?

4'-Dimethylamino 7,8 Dihydroxyflavone (4’-DMA-7,8-DHF) is a nootropic compound derivative of the naturally occurring flavone 7,8 Dihydroxyflavone (7,8 DHF). 4’-DMA-7,8-DHF differs from 7,8-DHF by the addition of a dimethylamino group off the 4 position on the flavone base structure. A dimethyl amino group consists of a nitrogen atom with two methyl groups.

Chemical Properties of 4’-DMA-7,8-DHF

4’-DMA-7,8-DHF is slightly water soluble and also slightly lipid soluble, this is derived from the cLogP value of 4’-DMA-7,8-DHF, which is 2.28. This means that 4’-DMA-7,8-DHF can readily transition from the aqueous phase to the lipid phase. Below is an in depth description of 4’-DMA-7,8-DHF chemical properties: 

Molecular formula: C17H15NO4

Molecular weight: 297.31 g/mol

Number of Heavy Atoms: 22

Number of aromatic heavy atoms: 16

Fraction of SP3 Carbon: 0.12 

Number of rotatable bonds: 2

Number of hydrogen bond acceptors: 4

Number of hydrogen bond donors: 2

Molar refractivity: 86.17

Topological polar surface area: 73.91 square Angstrom

CAS: 1205548-04-4

IUPAC: 2-[4'-(dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one

What Is The Difference Between 7,8 DHF and 4’-DMA-7,8-DHF?

4’-DMA-7,8-DHF shares the same chemical structure as 7,8 DHF, but with the addition of a dimethylamino group at the 4 position off the flavone base structure. The dimethylamino significantly changes a few key chemical properties of 7,8 DHF, of particular note are:

Number of heavy atoms (4’-DMA-7,8-DHF gains 3 heavy atoms)

  • 7,8 DHF: 19

  • 4’-DMA-7,8-DHF: 22

Fraction of SP3 Carbon (difference of 0.12) 

  • 7,8 DHF: 0.00

  • 4’-DMA-7,8-DHF: 0.12

Rotatable bond (4’-DMA-7,8-DHF gains 1 additional rotatable bond)

  • 7,8 DHF: 1 rotatable bond

  • 4’-DMA-7,8-DHF: 2 rotatable bonds

Molar refractivity (difference of 14.2)

  • 7,8 DHF: 71.97

  • 4’-DMA-7,8-DHF: 86.17

The rest of the chemical properties stay largely unchanged, for example, 7,8 DHF and 4’-DMA-7,8-DHF have the same amount of aromatic heavy atoms, hydrogen bond donors and hydrogen bond acceptors. Their cLogP’s are also very similar (7,8 DHF: 2.35 vs 4’-DMA-7,8-DHF: 2.28), thereby indicating that 7,8 DHF and 4’-DMA-7,8-DHF are going to largely have the same water and lipid soluble properties. Their topological polar surface area is also very similar, and only differs by 3.24 square Angstrom (7,8 DHF: 70.67 vs 4’-DMA-7,8-DHF: 73.91).

4’-DMA-7,8-DHF Reviews

To gain more insight, see the 4’-DMA-7,8-DHF reviews and experiences below.

Where to Buy 4’-DMA-7,8-DHF Capsules

Nootropics Depot offers 30ct. or 90ct. jars of 4’-DMA-7,8-DHF capsules. Nootropics Depot's 4’-DMA-7,8-DHF capsules have been lab-tested and verified for both product purity and identity.

 *Attention: All chemical compounds have risks. Please read the available research and understand the associated risks before handling. If you are uncertain of the appropriate handling methods, please consult a qualified professional. Misuse of this product may result in adverse reactions. This product is not approved by the FDA.

Reviews

  • 4
    Life-changing but has caveats

    Posted by Ram G on 14th Dec 2021

    This has repaired most of the brain fog I've been suffering from for the past year, but there are 2 major issues that need to be addressed if you're going to take it: 1. Headaches. You may need to supplement heavily with a choline source to avoid headaches. Citicholine and centrophenoxine are my go-tos but others should work. 2. Sleep. Numerous users have reported sleep issues with this because it remains bioactive for 8-12 hours, and I experienced this for about a week, but I've actually found that taking it shortly before bed results in better sleep with fewer interruptions than I've had in a very long time, which might be due to a rebound effect as it wears off (I speculate this may be also be related to how TRKB suppresses orexin-a). I'm also taking polygala as this seems to be a consistent factor for people that have had a good experience with this.

  • 4
    These nootropics are great!

    Posted by Cassandra on 1st Dec 2021

    The compounds of this supplement were exactly what I was looking for and they work great. It's easiest to take these when you don't have anything else to do for the day, because they are hard on the digestion process.

  • 4
    Good for the downtimes

    Posted by Peter on 1st Oct 2021

    Works great when you’re feeling unmotivated and restless.

  • 2
    Caused anxiety, insomnia

    Posted by Nancy on 27th Sep 2021

    I was really hopeful for this product when I read the reviews, but it amped up my anxiety and brought on horrible insomnia (even though I took it early in the morning and took polygala in the afternoon to "regulate" it). I'm glad it's worked for some, but not for me. I wish I could send back the bottle, but ND has a strict no-returns policy on open merchandise.

  • 5
    Most useful product here

    Posted by Steve on 26th Aug 2021

    Top quality as usual, I won’t buy anywhere else. Also one of the most useful products here, it’s very much like the original 7,8-dihydroxyflavone but works consistently and without requiring sublingual dosing.

  • 5
    subtle but useful

    Posted by baidhir hidair on 7th Jul 2021

    will give you focus and a clear state of mind

  • 5
    4-dma

    Posted by Austin on 4th Jul 2021

    Excellent for neural plasticity. Personally the best supplement I've tried for my situation, that's after 15 years of following the nootropics game.

  • 5
    It doesn't help me get by. it helps me get better

    Posted by Joshua L on 23rd Jun 2021

    I have struggled with serious mood problems for several years, at times truly debilitating, a result of some trauma and natural disposition. I have put off writing a review, but it's been such a help to me I feel obligated to recommend it to others. First, I do not "feel" anything immediate or discrete when taking this. It's not like caffeine or some of the racetams, so I would not expect that response. But after taking it about a week, I find that my baseline mood and disposition is improved, as well as mental clarity. It is as if it gets me "unstuck" from the (negative) patterns of mood and thoughts that had been weighing me down. It doesn't brighten or lift my mood per se, but it feels like it promotes new pathways to move away from those existing patterns, both emotionally and cognitively. And it feels perfectly natural, like I am just "getting out of the rut" or "finding my way out of a dark place" -- not some artificial or altered experience, nor like a masking. I have not had any side effects like emotional blunting or mental fog like so many conventional treatments I have tried. In fact, it is just the opposite, my mind is clearer than it has been in years. I think this mechanism of action is truly a breakthrough. You should give this a try as a daily "maintenance" nootropic for a few weeks, there is nothing else like it on the market.

  • 4
    It's near-death experience in a bottle.

    Posted by Rob Haskell on 19th Jun 2021

    At least, thats the best way I could describe it. I stopped taking it because it seemed kind of pointless/not worth it to me. My experience: I bumped my head and got a light concussion at work after being on this stuff for a week, and after that for another week+, Id wake up every single day thinking I was still at work. Another user on Reddit also reported that after starting and taking it, he had a dream where a strange man said "I hope you know youll never forget this moment." I will say that I seemed to experience increased precision in my motor skills. Not fine motor skills, but full body motor skills. I'd say this with a ~7/10 rating that it was NOT placebo. I was trying to take it for nerve pain, and it mightve helped, tho Id only rate this a 6/10 chance that that effect wasnt placebo. So this isnt a useless product. It just seems to me that what it does achieve, it does so in a way thats not suitable for regular use. The title of my review sums up what I think it does. Youre not wasting your money if you want to experiment with it though, by any means. Its not a sugar pill. Oh I almost forget that the very first time I took it, I felt a shot of euphoria some 15 or 30 minutes in. Like the description says, it is fast acting. That feeling was followed by a sense of seriousness. I guess you could call the feeling positive or uplifting, but Id describe it more as that I cared about what happened next and seriousness. And the dosing seems pretty proper to me. You could probably take 2 an hour apart if you wanted to yet I could tell that it was doing something with just one. Thats all I got. Knock yourself out lol

  • 3
    Mild stimulation and mood lift

    Posted by Biochem student on 20th May 2021

    I started with one capsule (felt nothing) and titrated my dose up to 4 capsules. I felt the same at 32mg as 16mg, which is mild stimulation and the kind of mood lift one might get as the effects of a phenethylamine type compound might give as it sets in. However, it never becomes euphoric in this sense. I am curious to try taking a higher dose to see what happens... No noticeable side effects.

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*Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.