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Dose
200mg (Per Serving)
Dose Timing
Flexible
How to Take
With Or Without Food
Dose Frequency
1 Time Daily
Apigenin is a natural flavonoid that improves mood, balances inflammation, supports metabolic function, and helps manage stress, making it a versatile supplement for overall well-being and emotional balance.
Apigenin is a flavone found in many different plant species, with notable plants including chamomile and parsley, but it is also found in Baikal skullcap for example. In fact, our Baikal Skullcap extract actually contains 15% apigenin! Apigenin is well known for its sleep promoting effect and supportive effects for cognitive function, digestive function, balanced oxidation levels and cellular function. Keep on reading to find out more about this awesome supplement!
While Apigenin can also be found in many of the foods that we consume on a daily basis, such as celery and oranges, the levels that can be found in our diet don’t come anywhere near the levels we are able to achieve with 98% pure apigenin supplementation! So if you are looking to get the most out of apigenin, then keep on reading.
Apigenin recently garnered a whole lot of attention when it was discussed in some popular podcasts. Indeed, apigenin is a great compound that can be taken close to bedtime to help with sleep due to its GABAergic effects. It is likely then also not a surprise that one of the compounds within chamomile that contributes to the relaxation and sleep promoting effects, is apigenin. The sleep promoting effects of apigenin may however take a little while to fully develop, similar to how the memory promoting effects of Bacopa monnieri can take a few weeks. The reason this appears to be the case with apigenin, is because it upregulates a very important enzyme necessary for GABA synthesis, glutamate decarboxylase (GAD67). GAD67 catalyzes the reaction that turns glutamate into GABA. In fact, the majority of GABA is produced through this GAD67 mediated pathway, and thus it is no surprise that apigenin can help with sleep, as GABA is a major player when it comes to inducing sleep. However, it also makes sense that these effects may take a while to develop, since we are relying on enzyme upregulation which is often a very slow process, albeit a very rewarding process!
The GAD67 upregulating effects also extend to apigenins relaxation inducing effects. GABAergic effects also mediate the majority of the relaxing effects we all know and love, and since we are overtime upregulating one of the main GABA producing pathways, apigenin is a fantastic long term solution for promoting everyday relaxation.
The fascinating thing with Apigenin, is that while it has sleep and relaxation promoting effects, it also has some pronounced nootropic effects. One of the main pathways by which apigenin creates this effect, is by allosterically potentiating alpha 7 nicotinic acetylcholine receptors (α7 nAChR), which is a fascinating target for nootropic effects! In fact, we can go a step further and say that within the nootropic world, a safe, readily accessible and overall affordable α7 nAChR allosteric potentiator is a bit of a holy grail, and with that in mind, apigenin stands strong as a natural nootropic!
Now the effects of apigenin don’t just extend to our brains, in fact, apigenin has some wonderful effects on overall health! One very interesting effect that apigenin has, is that it blocks an enzyme called CD38. This enzyme breaks down NAD+, a very important compound for overall health. NAD+ production is actually one of the reasons why we supplement NMN too! By inhibiting CD38, NAD+ levels should be promoted and may stay elevated for much longer. This brings up an interesting stack idea too, supplementing apigenin and NMN together for enhancing NAD+ levels synergistically!
Studies have also shown that Apigenin helps to support the regulation of various bacteria in the gut microbiota. When Apigenin first enters the body, the first place it interacts with is the colon which makes it the focus of many studies of the digestive function benefits. A study found that while Apigenin does not promote the actual number of gut microbiota, it does help to promote the diversity of the gut microbiota to support digestive function! In addition to digestive function, Apigenin also supports cellular function, balanced oxidation levels and skin health! Another study even showed that Apigenin helps to mitigate oxidative stress caused by UV-B, which indicates that apigenin could be a fantastic compound for overall skin health. Clearly, this is not a supplement that you want to miss!
Sleep Stack: Apigenin + Magtein Magnesium L-Threonate Capsules + L-Theanine Capsules
A popular stack is combining apigenin, Magtein and L-Theanine together for sleep. We tried this stack out and liked it a lot, so give it a shot!*
Digestive Function Stack: Apigenin + EpiCor® Capsules
Both Apigenin and EpiCor® promote helpful bacteria in the gut to promote the overall function of the digestive system! That’s not all! This pair also promotes immune function!*
Balanced Oxidation Levels Stack: Apigenin + Reduced Glutathione Tablets
For balanced oxidation levels, the obvious addition to this stack is Reduced Glutathione! Apigenin and Reduced Glutathione work together to promote balanced oxidation levels while also supporting cognitive and cellular function!*
NAD+ Stack: Apigenin + Nicotinamide Mononucleotide Capsules
One of the main purposes of NMN supplementation is to enhance NAD+ levels in the body. Conveniently, apigenin helps slow down the breakdown of NAD+, by inhibiting an enzyme called CD38. When combining the NAD+ elevating effects of NMN with the NAD+ breakdown inhibition effects of apigenin, we can in theory produce a more pronounced effect on NAD+ levels than either in isolation! This is a big tip if you are interested in NAD+!*
As a dietary supplement, take 200mg of Apigenin daily.
To gain more insight, see the Apigenin reviews and experiences below.
Nootropics Depot offers a 10g jar of high quality Apigenin. Nootropics Depot’s Apigenin has been lab-tested and verified for both product purity and identity.
| *Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated by the FDA. |
Apigenin has a great calming effect and is wonderful for duration and quality of sleep. I take it right before bed and have no problem faking asleep or going back to sleep if my dog wakes me up in the middle of the night. I really notice a difference when I run out. The effects do not seem to diminish over time of use. A really powerful sleep combo for me is pairing Apigenin with ultra concentrated Red Reishi extract.
I would have loved to enjoy this product; however, it gave me stress the next day after use. I tried multiple times and achieved the same result. It's a shame because it definitely helped me sleep.
I really wanted to like this product because it has solid research behind it. It did help with my sleep; however, it caused severe anxiousness upon waking up. Even at low doses. Unfortunately, this makes the product useless. I like ND as a company, but this product didn't work for me.
I'm blown away at how awesome this stuff is and how no one has reviewed it yet. I got it for my partner as I had no interest in it originally after trying it though I'm in love. It's great for calm focus during the day and a deep, restful sleep at night. I've been waking up feeling refreshed and energized every morning since taking it. I believe it helps quicken recovery from my daily work outs too, and allowed for greater gains. This with the Shoden ashwagandha is a *chef's kiss.* I've tried many supplements over the last decade of my nootropic journey. This is one that I can't live without now, which I can say for only a few of these substances. Its modulation of A7 nicotinic receptors and its testosterone boosting properties are quite apparent. I don't generally like GABA A receptor agonists/enhancers, as they tend to make me spacey and somewhat depressed, but I do love this one. Goes great with my ADHD meds, too, and in general makes me less of a scattered mess. My partner, who is on the Autism spectrum, finds it helps prevent overstimulation and anxiousness when confronted with social situations. It's the first thing since he quit his benzo prescription a decade ago that allows him to sleep through the night undisturbed. I believe apigenin is great for neurodivergent people and really deserves so much more attention.
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