About Ginger Phytosome Capsules

Mitidol is a patented phytosome complex featuring ginger extract standardized to 2.4% gingerols and shogaols combined with acmella oleracea extract containing 0.3% spilanthol. This unique formulation targets the endocannabinoid system through CB2 receptor activation and FAAH enzyme inhibition, providing comprehensive support for pain management and balanced inflammatory response.

Our Mitidol Story

Natural Pain and Inflammation support has long relied on single-ingredient approaches that address one pathway at a time. Effective pain modulation requires targeting multiple mechanisms simultaneously, particularly the endocannabinoid system that governs how our bodies process discomfort. Traditional ginger extracts and acmella preparations existed separately, but nobody had combined them in a bioavailable phytosome format that could maximize their synergistic potential.

We partnered with Indena to bring Mitidol to market because their approach solved two critical problems: sourcing high-quality acmella oleracea (most market biomass is inferior quality) and creating a phytosome delivery system that dramatically improves absorption. Indena invested in dedicated farmland in Sardinia, Italy to cultivate premium acmella, making this one of the rare European-sourced botanical extracts. The phytosome technology wraps both extracts in phospholipids, ensuring the active compounds reach their targets effectively.

Mitidol's dual-pathway approach to pain management sets it apart. While ginger's gingerols and shogaols regulate inflammation through traditional pathways, acmella's spilanthol activates CB2 receptors and inhibits FAAH enzyme breakdown of endocannabinoids like palmitoylethanolamide. This creates a comprehensive pain modulation effect that addresses both the inflammatory cascade and the body's natural pain processing systems.

Benefits

• Supports Healthy Pain Management: Mitidol activates CB2 cannabinoid receptors throughout the body while inhibiting FAAH enzymes that break down natural endocannabinoids, creating a dual pathway that helps manage pain sensations quickly and effectively.
• Supports Healthy Inflammatory Response: The gingerols and shogaols from ginger work with acmella's spilanthol to regulate inflammatory cytokines and COX-2 pathways, while also supporting balanced oxidative stress levels.
• Supports Healthy Joint Function: The combination targets voltage-gated sodium channels and promotes balanced inflammatory responses in joint tissues, helping maintain comfortable movement and flexibility throughout daily activities.
• Supports Positive Mood: Ginger's traditional mood-lifting properties are enhanced by acmella's endocannabinoid effects, creating pleasant mood support that complements the Pain and Inflammation management benefits.

The phytosome delivery system significantly improves bioavailability of both extracts compared to standard forms, while Indena's cultivation of high-quality acmella in Sardinia ensures consistent potency of the active compound spilanthol. This European-grown botanical extract offers premium herbs for nerve pain with documented standardization levels.

Quality and Standardization

• Patented Mitidol Complex: Our Ginger Phytosome features the patented Mitidol ingredient developed by Indena, combining standardized ginger extract (2.4% gingerols and shogaols) with acmella oleracea extract (0.3% spilanthol) in a bioavailable phytosome delivery system.
• Premium European Sourcing: Indena cultivates their own high-quality acmella biomass on dedicated farmland in Sardinia, Italy, ensuring exceptional purity and potency compared to standard low-grade acmella typically available on the market.
• UPLC Testing Verification: Each batch undergoes rigorous testing using ultra-performance liquid chromatography (UPLC) to verify exact standardization levels and confirm the presence of key bioactive compounds including gingerols, shogaols, and spilanthol.
• Phytosome Technology: The patented phytosome formulation complexes both botanical extracts with phospholipids to significantly enhance bioavailability and absorption compared to standard herbal extracts, ensuring optimal therapeutic delivery.

Mechanism of Action

• CB2 Receptor Activation: Mitidol directly binds to and activates CB2 cannabinoid receptors throughout the body, which play a crucial role in regulating pain signaling pathways and inflammatory responses at the cellular level.
• FAAH Enzyme Inhibition: The combination blocks fatty acid amide hydrolase (FAAH), an enzyme responsible for breaking down endocannabinoids like anandamide and 2-AG, allowing these natural pain-modulating compounds to remain active longer in the system.
• Voltage-Gated Sodium Channel Blockade: Spilanthol from acmella creates its characteristic numbing sensation by blocking voltage-gated sodium channels, the same mechanism that prevents nerve impulses from transmitting pain signals to the brain.
• 5-HT3A Receptor Antagonism: Gingerols and shogaols from ginger block 5-HT3A receptors in the digestive system, which helps explain ginger's traditional use for stomach upset and contributes to overall comfort during stress responses.
• Phytosome Bioavailability Enhancement: The phospholipid delivery system creates a molecular complex that mimics cell membrane structure, dramatically improving absorption and allowing the active compounds to reach target tissues more effectively than standard extracts.

Overview of the Science

Ginger phytosome demonstrates significant neuroprotective properties through multiple molecular pathways. Research indicates that gingerol-enriched preparations help mitigate neuroinflammation by targeting gut-brain axis dysfunction, particularly in cases of intestinal permeability and associated nerve sensitivity [1]. The gingerols and shogaols in this formulation appear to modulate voltage-gated sodium channels and inflammatory mediators, while acmella's spilanthol compound provides complementary numbing effects through similar channel blockade mechanisms [2]. Studies suggest this dual-extract combination may be particularly effective for nerve-related discomfort, with the phytosome delivery system enhancing bioavailability of both botanical compounds [3].

The endocannabinoid system interactions of Mitidol extend beyond basic CB2 receptor activation. Clinical research demonstrates that the combination influences fatty acid amide hydrolase (FAAH) enzyme activity, leading to increased levels of endogenous cannabinoids like anandamide and 2-arachidonoylglycerol [4]. This mechanism creates a synergistic effect with the direct CB2 agonism, potentially explaining the rapid onset of effects reported by users. Additional studies on ginger compounds show promise for supporting healthy inflammatory responses in neural tissue, while acmella's traditional use as a "toothache plant" reflects its documented ability to modulate pain perception through multiple receptor pathways [5]. The combination may also support mood regulation through endocannabinoid-mediated mechanisms that influence neurotransmitter balance.

[1] Shen CL, Wang R, Ji G, Elmassry MM, Zabet-Moghaddam M, Vellers H, Castro M, Santos JM, Yakhnitsa V, Presto P, Liu X, Neugebauer V. Gingerol-Enriched Ginger Supplementation Mitigates Neuropathic Pain via Mitigating Intestinal Permeability and Neuroinflammation: Gut-Brain Connection. Front Nutr. 2022;9:950860.

[2] Walstab J, Krüger D, Stark T, Hofmann T, Demir IE, Ceyhan GO, Feistel B, Schemann M. Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol Motil. 2013;25(5):439-47.

[3] Mahomoodally MF, Sreekeesoon DP, Suroowan S, Gokhan Z, Puchooa D. Acmella oleracea for pain management. Fitoterapia. 2019;137:104230.

[4] Petrangolini G, Donzelli F, Berlanda D, Allegrini P, Rossignoli A, Stucchi M, Riva A. Targeting Cannabinoid Receptors and Fatty Acid Amide Hydrolase: An Innovative Food-Grade Delivery System of Zingiber officinale and Acmella oleracea Extracts as Natural Adjuvant in Pain Management. J Nutr Food Sci. 2019;10:766.

[5] Santos JM, Deshmukh H, Elmassry MM, Yakhnitsa V, Ji G, Kiritoshi T, Presto P, Antenucci N, Liu X, Neugebauer V, Shen CL. Beneficial Effects of Ginger Root Extract on Pain Behaviors, Inflammation, and Mitochondrial Function in the Colon and Different Brain Regions of Male and Female Neuropathic Rats: A Gut-Brain Axis Study. Nutrients. 2024;16(20):3563.

Ingredients

Ginger Phytosome with Acmella Oleracea:

• Zingiber officinale and Acmella oleracea extracts
• Standardized to 2.4% Gingerols and Shogaols, 0.3% Spilanthol
• 350mg per serving
• Incorporated into phytosome delivery system

The 2.4% standardization ensures consistent levels of ginger's most bioactive compounds, gingerols and shogaols, which are responsible for both the characteristic warming sensation and the compound's effects on pain pathways. The 0.3% spilanthol concentration from acmella provides the voltage-gated sodium channel blocking activity that creates the characteristic numbing sensation and contributes to the formula's rapid onset. This precise standardization combined with the phytosome delivery system maximizes absorption compared to standard extracts, making the active compounds more bioavailable for supporting supplements for nerve pain applications.