Excellent
This Magnolia is more potent then the one I had before from a competitor that was standardized to higher active constituents. I really love it for when I have a hard time sleeping.
Magnolia Bark, also known as Magnolia Officinalis, is natural compound used in traditional Chinese practices and known for its ability to support healthy sleep habits and its relaxation properties. Magnolia Bark is a plant from the Magnolia species of plants that share similar compounds. Two of the compounds, Magnolol and Honokiol are the two primary active ingredients found in the bark. Honokiol and Magnolol are two biphenolic structural isomers called neolignans. They were first found in plants in the Magnolia family and historically used to support stress and respiratory health.
In 1983, tests on mice were conducted to see how they would respond to Magnolia Bark extract. Magnolia Bark’s benefits for sleep were first documented in these studies when researchers noticed calm and relaxed behavior among the mice. Further studies performed on rats found regulated serotonin release after the rats were injected with Magnolol. As a result, metabolic rate and colonic temperature were notably reduced. Research determined that Magnolia Bark extract seems to interact with the serotonin transporter but so far has not discovered how it interacts with the serotonin transporter. However, it is able to regulate serotonin release from neurons.
The neolignans found in Magnolia Bark extract (Honokiol and Magnolol) have been found to interact with GABAA receptors in both in vitro and in vivo studies. Relaxation effects were noted with Magnolol in isolation and seems to promote healthy sleep patterns when taken orally. In addition, GABAA agonists will augment the effects. Clinical studies have found that the neolignans (Magnolol and Honokiol) in Magnolia bark seem to have a positive impact on modulating muscarinic acetylcholine receptors in a similar fashion to how they impact GABAA receptors. The neolignans in Magnolia Bark (Magnolol and Honokiol) seem to increase the binding affinity of muscarine to the muscarinic acetylcholine receptors. This is due to its ability to allosterically modify low binding receptors to a higher binding capacity and therefore causing a larger amount of overall binding. Magnolol and Honokiol both increased binding in rat cerebella by 64% and 71% respectively and 2.8 and 3.2-fold respectively in rat forebrains.
Magnolia Bark Extract Standardization
This Magnolia Bark Extract is standardized to Magnolol + Honokiol minimum content 80% by UPLC
As a dietary supplement, take 200mg of Magnolia Bark Extract once daily.
To gain more insight, read the Magnolia Bark Extract reviews and experiences below.
Nootropics Depot offers 10 gram or 20 gram jars of high-quality Magnolia Bark. Nootropics Depot’s Magnolia Bark has been lab-tested and verified for both product purity and identity.
ATTENTION: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
This Magnolia is more potent then the one I had before from a competitor that was standardized to higher active constituents. I really love it for when I have a hard time sleeping.
This is one of the best supplements for relaxing and stress relief i have ever tried!! It just melts all of the days stress away so i can get a good night sleep. This stuff makes you feel so so so relaxed and i don't think tolerance is a issue if you only use it once a day. The two major alkaloids activate the GABAa receptors and the CB1, CB2, Cannabinoid receptors. It modulates your GABAa receptors instead of agonizing them making the more sensitive to GABA. Honokiol is also a inverse agonist of the CB2 receptors and to a lesser extent the CB1 receptors, the same receptors that THC and CBD bind to creating a calming effect. Bioavailability is a issue with this supplements but I find that if you take it with Bioperine that it enhances absorption dramatically. You can also put it under your tongue for better bioavailability as well. Overall this is a great supplement and I'm about to order another jar just to have it on hand, it's that good!!
This Magnolia is more potent then the one I had before from a competitor that was standardized to higher active constituents. I really love it for when I have a hard time sleeping.
This is one of the best supplements for relaxing and stress relief i have ever tried!! It just melts all of the days stress away so i can get a good night sleep. This stuff makes you feel so so so relaxed and i don't think tolerance is a issue if you only use it once a day. The two major alkaloids activate the GABAa receptors and the CB1, CB2, Cannabinoid receptors. It modulates your GABAa receptors instead of agonizing them making the more sensitive to GABA. Honokiol is also a inverse agonist of the CB2 receptors and to a lesser extent the CB1 receptors, the same receptors that THC and CBD bind to creating a calming effect. Bioavailability is a issue with this supplements but I find that if you take it with Bioperine that it enhances absorption dramatically. You can also put it under your tongue for better bioavailability as well. Overall this is a great supplement and I'm about to order another jar just to have it on hand, it's that good!!
It works really well, it's a very good product. I am very pleased with the effects. However, sublingual application can significantly burn your mouth. I kept it under my tongue longer than I intended (my own fault) and now have chemical burns that cause extreme pain and have stopped the flow of saliva. It should be fine if done for a limited time only, but please proceed with caution. I've had these burns for the last 48 hours and they are highly unpleasant.
This is one of the most effective products I have bought here. I just use it after stress episodes, 200mg, sublingual. I always feel very relaxed 10 min after. Worth purchasing.
Contrary to the other review here. This has to be taken sublingually, it definitely has a sting about it. However the effects are potent even at 100mg. They last about 2 hours on average. I get strong sedation and relaxation from this powder. It has little effect for me if I don't use it sublinugally.
Provides a mild reduction in anxiousness and tension without causing fatigue. Seems to only work on an empty stomach. I usually need 600mg to feel any effect though. Do not use the sublingual route with this stuff it is a bit caustic to the mouth.
This product is extremely relaxing. I went ahead and got the 20g tub because I had faith in this efficacy of this product because I have never been let down by any of Nootropic Depot’s products. I’m definitely going to make another purchase. The only thing I wish is that I could get it in a larger size! Maybe soon?
