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Magnolia Bark, also known as Magnolia Officinalis, is natural compound used in traditional Chinese practices and known for its ability to support healthy sleep habits and its relaxation properties. Magnolia Bark is a plant from the Magnolia species of plants that share similar compounds. Two of the compounds, Magnolol and Honokiol are the two primary active ingredients found in the bark. Honokiol and Magnolol are two biphenolic structural isomers called neolignans. They were first found in plants in the Magnolia family and historically used to support stress and respiratory health.
In 1983, tests on mice were conducted to see how they would respond to Magnolia Bark extract. Magnolia Bark’s benefits for sleep were first documented in these studies when researchers noticed calm and relaxed behavior among the mice. Further studies performed on rats found regulated serotonin release after the rats were injected with Magnolol. As a result, metabolic rate and colonic temperature were notably reduced. Research determined that Magnolia Bark extract seems to interact with the serotonin transporter but so far has not discovered how it interacts with the serotonin transporter. However, it is able to regulate serotonin release from neurons.
The neolignans found in Magnolia Bark extract (Honokiol and Magnolol) have been found to interact with GABAA receptors in both in vitro and in vivo studies. Relaxation effects were noted with Magnolol in isolation and seems to promote healthy sleep patterns when taken orally. In addition, GABAA agonists will augment the effects. Clinical studies have found that the neolignans (Magnolol and Honokiol) in Magnolia bark seem to have a positive impact on modulating muscarinic acetylcholine receptors in a similar fashion to how they impact GABAA receptors.* The neolignans in Magnolia Bark (Magnolol and Honokiol) seem to increase the binding affinity of muscarine to the muscarinic acetylcholine receptors. This is due to its ability to allosterically modify low binding receptors to a higher binding capacity and therefore causing a larger amount of overall binding. Magnolol and Honokiol both increased binding in rat cerebella by 64% and 71% respectively and 2.8 and 3.2-fold respectively in rat forebrains.
Magnolia Bark Extract Standardization
This Magnolia Bark Extract is standardized to Magnolol + Honokiol minimum content 80% by UPLC
As a dietary supplement, take 200mg of Magnolia Bark Extract once daily.
To gain more insight, read the Magnolia Bark Extract reviews and experiences below.
Nootropics Depot offers 10 gram or 20 gram jars of high-quality Magnolia Bark. Nootropics Depot’s Magnolia Bark has been lab-tested and verified for both product purity and identity.
| *Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
This product is extremely relaxing. I went ahead and got the 20g tub because I had faith in this efficacy of this product because I have never been let down by any of Nootropic Depot’s products. I’m definitely going to make another purchase. The only thing I wish is that I could get it in a larger size! Maybe soon?
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