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Magnolia Bark, also known as Magnolia Officinalis, is a natural compound used in traditional Chinese practices and known for its ability to support healthy sleep habits and its relaxation properties. Magnolia Bark is a plant from the Magnolia species of plants that share similar compounds. Two of the compounds, Magnolol and Honokiol are the two primary active ingredients found in the bark. Honokiol and Magnolol are two biphenolic structural isomers called neolignans. They were first found in plants in the Magnolia family and historically used to support stress and respiratory health.
In 1983, tests on mice were conducted to see how they would respond to Magnolia Bark extract. Magnolia Bark’s benefits for sleep were first documented in these studies when researchers noticed calm and relaxed behavior among the mice. Further studies performed on rats found regulated serotonin release after the rats were injected with Magnolol. As a result, metabolic rate and colonic temperature were notably reduced. Research determined that Magnolia Bark extract seems to interact with the serotonin transporter but so far has not discovered how it interacts with the serotonin transporter. However, it is able to regulate serotonin release from neurons.
The neolignans found in Magnolia Bark extract (Honokiol and Magnolol) have been found to interact with GABAA receptors in both in vitro and in vivo studies.
Relaxation effects were noted with Magnolol in isolation and seems to promote healthy sleep patterns when taken orally. In addition, GABAA agonists will augment the effects. Clinical studies have found that the neolignans (Magnolol and Honokiol) in Magnolia bark seem to have a positive impact on modulating muscarinic acetylcholine receptors in a similar fashion to how they impact GABAA receptors.
The neolignans in Magnolia Bark (Magnolol and Honokiol) seem to increase the binding affinity of muscarine to the muscarinic acetylcholine receptors.* This is due to its ability to allosterically modify low binding receptors to a higher binding capacity and therefore causing a larger amount of overall binding. Magnolol and Honokiol both increased binding in rat cerebella by 64% and 71% respectively and 2.8 and 3.2-fold respectively in rat forebrains.
Magnolia Bark Extract Standardization
This Magnolia Bark Extract is standardized to Magnolol + Honokiol minimum content 80% by UPLC
As a dietary supplement, take one 200mg Magnolia Bark Extract tablet once daily.
To gain more insight, read the Magnolia Bark Extract tablets reviews and experiences below.
Nootropics Depot offers 30ct. and 90ct. jars of high-quality Magnolia Bark extract tablets. Nootropics Depot’s Magnolia Bark has been lab-tested and verified for both product purity and identity.
| *Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
Back in 2021, the doctor told me to quit Xanax cold turkey, no need to say I almost died! It was the hardest thing I have ever gone through! I tried different supplements to help me! For the first two years, I had a hard time finding something that would help me until I found this supplement. This brand is also the best quality! I totally recommend it.
I don’t like bad reviews but… this has given me hives. Took awhile to Isolate but I’m 98% sure this is it. I will give it another try when I stop truck driving and can get back into a better health routine. This is the second batch I bought. The first one didn’t do it to me I don’t think.
I've previously individually taken valerian root, glycine, and a few other substances all to try and help out my sleep issues. My main issue is that no matter when I go to bed, I pretty much always wake up at 8 or 9 AM, and tend to be a light sleeper to noise and thermal changes while asleep - giving me a lot of energy and irritation issues when my sleep is almost always interrupted. This magnolia bark has been a great, mild way that I notice helps me stay asleep better and fall asleep faster, without sedative effects. Glycine has previously worked well for me in in this way as well, but I was getting tired of taking three giant pills before bed, and my stomach wasn't tolerating all that powder well. These tablets are much smaller and easier to take before bed, with similar effect. Thanks for stocking this!
A great product - part of my sleeping stack. Do yourself a favor and look into intermediate and advanced stacks with this product.
I use this product for inflammation I take one A-day most generally I have post polio syndrome and it's amazing how much it helps the pain and it has so many other redeeming qualities Google it and read about everything it's harmless best I can tell and really does help!!
Magnolia is a little strong for me, so having the scored tablets improves it usefulness. Improves sleep onset, but seems to keep me in a lighter REM state too long. Might be good if you want those dreams.
It would be this. It is just solid for so many things if you will in your body and brain. It affects the activity of both serotonin and dopamine. And I also take Ginger and never have any sort of mood issues. In addition to reducing cortisol, helping with slumber. It seems to improve a variety of mood state parameters anecdotally, and I'm an ADHD PI and I know it helps subtlety with my attention issues, however you can feel it. And it's really makes a difference with my oral health come including bacteria build up, and my gums never bleed anymore after supplementing magnolia bark. How do you make sure I cycle it, maybe two weeks on 2 weeks off kind of thing. And finally knowing it helps somewhat with brain information, this herb does a lot of good things for one's body. Thanks ND for providing such a high quality version!
Don't look to this to knock you out, however the first few times I took it I noticed I was a bit drowsy. Now that I take it regularly it's definitely not even noticeable, I take this in the evenings with Magtein & zinc & I do notice it takes an edge off though...I'm less apt to worry about work etc. Exactly what I wanted. Question for the ND Admin, can I take 2 pills daily? I've read that it's safe to take up to 500mg daily and I'm 6' 1" 200lbs. Any input is appreciated, thanks!
I am taking it at night for sleep. Routinely I sleep about 4-5 hours with periods of wakefulness lasting a half hour to two hours. It takes a long time to fall asleep. I won't buy these again awhen I run out UNLESS my sleep patterns get worse,, then I'll believe they were helping a bit and may try them again.
I take it at night to help me sleep and it sure does! ND is the best!
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