If you are looking to promote cellular energy and rejuvenate yourself, then increasing NAD+ levels should be at the top of your priority list! There are various ways in which we can increase NAD+ levels, one of the most common ways being supplementing with an NAD+ precursor. Nicotinamide riboside is one of these NAD+ precursors and thus, supplementing with nicotinamide riboside is a great way to enhance vitality!
NAD+ levels tend to decline as we age, and this can underlie some of the age-related declines in energy levels and overall vitality we oftentimes experience. With this in mind, if you are looking to regain your youthful energy, then nicotinamide riboside is the perfect fit for you!
If you are trying to decide between our NR and NMN, then we need to look at where each one excels. NMN seems to take the lead when we consider purely its NAD+ elevating effects, however, NR does something quite unique! NR itself appears to be quite neuroprotective, independent from its ability to increase NAD+ levels. So, if you are looking for the most neuroprotective NAD+ precursor, then NR is the one for you!
Nicotinamide riboside (NR) is a naturally occurring Vitamin B3 (niacin) derivative whose main purpose is often to be converted into either nicotinamide adenine dinucleotide (NAD+), nicotinamide (NAM) or even NMN! NR is mostly absorbed in the liver where it then begins its journey to being converted into either NAD+, NAM or NMN. There are many different foods and drinks that naturally contain NR, but at nowhere near the levels we can achieve with supplementation!
Nicotinamide riboside is very well researched for its function as an NAD+ precursor and is seen as one of the best ways in which to increase NAD+ levels! NAD+ plays a major role in energy production, balancing oxidation levels, metabolic function and more! Although NR isn’t the only precursor option for NAD+, it is often thought to be one of the more stable options for long-term NAD+ production and for brain specific effects.
In addition to NAD+, NR also functions as a precursor to NMN and nicotinamide (NAM). NAM helps to promote cardiovascular function while NMN promotes balanced oxidation levels and cellular function, while also acting as another highly efficient NAD+ precursor. In fact, for NR to produce NAD+, it first has to be converted to NMN! With this in mind it is then quite clear that the reason these compounds are created from NR, is due to the fact that NMN and NAM both participate in the same cycle through which NR produces NAD+.
One of NR’s claims to fame is its neuroprotective effects. This is also where NR seems to be more specialized when compared to NMN, another highly effective NAD+ precursor. This likely has to do with the fact that NR supplementation can directly affect NR related pathways in axons of neurons, where it can then locally produce fairly high levels of NAD+. Having higher levels of NAD+ in axons appears to be a fantastic neuroprotective strategy.
Things get a little bit more interesting when we really dive into the research behind NR’s neuroprotective effects though. It appears that NR itself is producing some of these neuroprotective effects, as NR seems to be more neuroprotective when compared to NAD+ itself. This further points to the fact that NR is the best NAD+ precursor to take if neuroprotection is one of your main goals!
The NAD+ Stack: Nicotinamide riboside + Apigenin Capsules
Supplementing with NR is a fantastic way to increase NAD+ levels, however, adding in apigenin can take things to the next level! Apigenin inhibits CD38, an enzyme which breaks down NAD+. Thus, when we inhibit CD38 with apigenin, the NAD+ we generate through NR supplementation will survive for longer in the body, and will be able to exert even more beneficial effects!
The Cellular Energy Stack: Nicotinamide riboside + Creatine Monohydrate Powder
NR supplementation enhances cellular energy levels by increasing NAD+ levels, which also enhances ATP production. Thus, it makes sense to further exploit this pathway by taking one of the best ATP enhancers around; creatine monohydrate. These two together will make a great stack for promoting exercise performance!
The Neuroprotection Stack: Nicotinamide riboside + Reduced Glutathione Tablets
NR can exert both direct and indirect neuroprotective effects via elevating NAD+ levels. One of the ways in which the extra NR and NAD+ levels help protect our brains, is through its effects on oxidative stress and neuroinflammation. These are some of the same factors on which reduced glutathione, another endogenous compound, acts. In fact, we need high levels of both reduced glutathione and NAD+ for ideal neurological functioning, and thus this stack covers the foundations for neuroprotection!
As a dietary supplement, take 300mg of Nicotinamide riboside daily.
To gain more insight, see the Nicotinamide riboside reviews and experiences below.
Nootropics Depot offers 10g, 30g or 100g jars of high quality Nicotinamide riboside. Nootropics Depot’s Nicotinamide riboside has been lab-tested and verified for both product purity and identity.
Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.