What is Nobiletin?
Nobiletin is an O-methylated flavone that is most commonly found in citrus peels from species like Citrus aurantium. Citrus aurantium has extensive use in Traditional Chinese practices for everything from supporting metabolic function to promoting feelings of well-being, and even promoting cognitive function! Nobiletin was first isolated in the 1930s from citrus oil and various research conducted since its discovery led scientists to believe that Nobiletin helped support balanced oxidation levels, inflammation levels, and even had a role in promoting metabolic function! Recent trials have revealed that Nobiletin also carries intriguing benefits to circadian rhythms and cognitive function! Let’s get a closer look at Nobiletin's benefits:
Nobiletin Benefits and Uses
- May help promote cognitive function
- May help support circadian rhythms
- May help support metabolic function
- May help promote cardiovascular function
- May help support balanced inflammation and oxidation levels
Why is Nobiletin Important?
Although Citrus aurantium’s most well known benefits are supporting cardiovascular and metabolic function, some research indicates that there may be other benefits associated with Nobiletin. Interesting research has found that Nobiletin, a flavonoid found in citrus fruits, may play a substantial role in promoting cognitive function! Scientists compared data from a Bitter Orange extract high in Nobiletin to other Bitter Orange samples and found that Nobiletin interacted with AMPA receptors, a critical component of Long Term Potentiation (LTP). LTP is one of the main mechanisms by which memories are created, and by interacting with AMPA receptors, Nobiletin may help promote memory!
AMPA receptors are widely distributed through the Central Nervous System and hippocampal regions where they serve as both cation channels and glutamate receptors, which are integral to synaptic transmission and plasticity. These elements, in particular, are said to be the core of important cognitive processes such as memory. Additional evidence even suggests Nobiletin supplement may help support balanced inflammation and oxidation levels which forms the basis of its neuroprotective properties!
Some recent research even concluded that Nobiletin also helps support circadian rhythms. The circadian rhythm is generally understood as the process behind the sleep-wake cycle, but it is also the internal process that largely coordinates mental and physical functions, and regulates the sleep-wake cycle. Nobiletin was found to promote overall circadian rhythmic functions on a cellular level, thus supporting the foundations for cardiovascular, metabolic, and cognitive processes. These benefits of Nobiletin were observed across both human and animal trials in various fields of research, giving researchers more confidence that a Nobiletin supplement can provide an array of diverse benefits!
Cognitive Function Stack: Nobiletin with DMAE L-Bitartrate
This combination is perfect for those needing an effective and targeted approach to supporting cognitive function!
Cardiovascular Support Stack: Nobiletin with Tart Cherry
Stack Nobiletin with Tart Cherry for a comprehensive and effective approach to supporting cardiovascular function!
Metabolic Function Stack: Nobiletin with Berberine HCL + Silymarin
Nobiletin paired with Berberine HCL + Silymarin is a tailored two pronged approach to supporting overall metabolic function!
As a dietary supplement, take 250mg of Nobiletin powder daily.
To gain more insight read the Nobiletin reviews and experiences below.
Where to Buy Nobiletin?
Nootropics Depot offers 15g or 30g jars of Nobiletin powder. Nootropics Depot's Nobiletin powder capsules has been lab-tested and verified for both product purity and identity.
Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.