About Redaxin Capsules

Redaxin is a standardized extract from the 'Red Natural' cultivar of Sorghum bicolor, concentrated for ultra-rare 3-deoxyanthocyanidins including apigeninidin and luteolinidin. These unique compounds support fitness recovery, cognition, and mood, while luteolinidin acts as a potent CD38 inhibitor to help maintain NAD+ levels.

Our Redaxin Story

In 2009, University of Kentucky researcher Seth Debolt discovered something extraordinary: one plant among 2 million sorghum specimens was completely red, even its leaves. Testing revealed this unique coloration came from exceptionally high levels of 3-deoxyanthocyanidins, compounds so rare they exist primarily in obscure ferns and mosses. While normal sorghum contains these bioactives in tiny amounts, this single plant produced them abundantly.

We saw the potential in this 1-in-2-million natural anomaly and worked with cultivators to breed it into the stable 'Red Natural' variety. Our Redaxin extract captures these ultra-rare compounds that research suggests support antioxidant defenses and healthy inflammation responses. The entire process, from cultivation in Kentucky to final extraction and testing, happens exclusively in the United States, giving you an all-American supplement born from nature's rarest discovery.

Benefits

• Enhances Cognition: Redaxin produces subtle focus and mental clarity effects that fall between the relaxing qualities of apigenin and the stimulating properties of C3G, creating balanced cognitive enhancement that supports clear thinking without overstimulation.
• Enhances Exercise Recovery: Human clinical trials show that Redaxin's 3-deoxyanthocyanidins accelerate post-workout recovery through their potent oxidation and inflammation regulating properties, similar to other anthocyanin-rich compounds like tart cherry and C3G.
• Elevates Antioxidant Defenses: The rare apigeninidin and luteolinidin compounds in Redaxin provide powerful oxidative stress protection, neutralizing free radicals and supporting cellular health through mechanisms that complement the body's natural antioxidant systems.
• Mood-Boosting Effects: Users report unique mood elevation that captures elements of both calming and energizing compounds, creating balanced emotional states that support daily well-being without the extremes of purely sedating or stimulating supplements.

The luteolinidin in Redaxin acts as a potent CD38 inhibitor, which prevents the breakdown of NAD+ and naturally supports cellular energy production. This mechanism makes Redaxin an excellent complement to NAD+ precursor supplements, enhancing their effectiveness while providing its own unique benefits for recovery and cognitive function.

Quality and Standardization

• Single-Plant Cultivar Standardization: We source exclusively from the 'Red Natural' cultivar of Sorghum bicolor, a genetically stable strain bred from one anomalous plant discovered among 2 million specimens at the University of Kentucky, ensuring consistent 3-deoxyanthocyanidin profiles across every batch.
• American-Grown Supply Chain: Our Redaxin is cultivated, extracted, and processed entirely in Kentucky, providing complete vertical integration from field to finished product within the United States for maximum quality control and traceability.
• Compound-Specific Standardization: Each batch is standardized for the primary 3-deoxyanthocyanidins apigeninidin and luteolinidin, targeting these ultra-rare bioactives that exist in negligible quantities in standard sorghum varieties.
• Third-Party Verified Purity: We verify both product identity and purity through independent laboratory testing, ensuring our extract maintains the unique chemical fingerprint of the 'Red Natural' cultivar without contaminants or adulterants.

Mechanism of Action

• 3-Deoxyanthocyanidin Biosynthesis: The 'Red Natural' cultivar produces exceptionally high levels of apigeninidin and luteolinidin through an amplified phenylpropanoid pathway, where these rare compounds accumulate as secondary plant defense metabolites in response to environmental stressors.
• CD38 Enzyme Inhibition: Luteolinidin specifically targets and inhibits CD38, a key enzyme responsible for breaking down NAD+, thereby preventing cellular NAD+ depletion and supporting healthy energy metabolism at the mitochondrial level.
• Antioxidant Network Activation: The 3-deoxyanthocyanidins enhance endogenous antioxidant systems by upregulating glutathione peroxidase and catalase enzymes, creating a protective cellular environment that supports healthy oxidative balance.
• Exercise-Induced Adaptation Signaling: Clinical research indicates these compounds modulate post-exercise inflammatory cascades and muscle recovery pathways, supporting the body's natural adaptation processes to physical training and cellular health maintenance.

Overview of the Science

Research demonstrates that the 3-deoxyanthocyanidins in Redaxin possess potent anti oxidative stress properties, with studies showing these compounds can significantly reduce LDL oxidation and improve overall antioxidant capacity [1]. The luteolinidin component specifically acts as a CD38 inhibitor, with research confirming its ability to preserve NAD+ levels in postischemic heart tissue by preventing enzymatic degradation [2]. Additionally, flavonoids including the 3-deoxyanthocyanidins have been validated as effective CD38 inhibitors in multiple studies, supporting their role in cellular health and longevity pathways [3].

The sorghum bicolor varieties containing these bioactive compounds have shown significant antioxidant and antiproliferative effects in controlled research settings [5]. Studies on West African sorghum varieties have demonstrated notable anti-inflammatory and immune-modulating properties, suggesting these compounds may influence multiple biological pathways beyond their primary antioxidant functions [6]. While research on 3-deoxyanthocyanidins remains limited due to their rarity, initial findings indicate these molecules may offer unique therapeutic potential distinct from conventional anthocyanins.

[1] Carbonneau MA et al. Food Chem. 2014;145:701-9.

[2] Boslett J et al. J Pharmacol Exp Ther. 2017;361(1):99-108.

[3] Kellenberger E et al. Bioorg Med Chem Lett. 2011;21(13):3939-42.

[5] Awika JM et al. LWT - Food Sci Technol. 2009;42(6):1041-6.

[6] Benson KF et al. J Med Food. 2013;16(3):230-8.

Ingredients

Red Sorghum Bioflavonoid Complex:

• Sorghum bicolor ('Red Natural' cultivar) extract
• 20% polyphenols standardization
• 500mg per capsule

The 20% polyphenol standardization ensures consistent delivery of the rare 3-deoxyanthocyanidins that make Redaxin unique. This standardization level captures the concentrated apigeninidin and luteolinidin content that distinguishes the 'Red Natural' cultivar from ordinary sorghum varieties. By maintaining this specific polyphenol threshold, each capsule delivers reliable amounts of these ultra-rare bioactives that would otherwise require consuming massive quantities of regular sorghum to obtain equivalent concentrations. This pharmaceutical-grade standardization makes Redaxin a practical source of compounds that exist in negligible amounts throughout the rest of the plant kingdom, supporting both longevity pathways through CD38 inhibition and comprehensive anti oxidative stress supplements applications.