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If you have ever been interested in trying out glutathione, or perhaps you have already been taking reduced glutathione, then S-Phenylacetyl Glutathione is a very interesting option! This form of glutathione has been stabilized with a phenylacetyl group, which makes it act like a precursor to glutathione. This has some distinct advantages. For example, various enzymes that can break down glutathione now lose the ability to break down glutathione and instead go to work cleaving off the phenylacetyl group from S-Phenylacetyl L-Glutathione. This then yields glutathione, and has the distinct advantage of being able to get into cells in higher concentrations, as S-Phenylacetyl L-Glutathione is protected from premature breakdown in our stomach, intestines, and plasma.
If you are not familiar with glutathione, you may be asking yourself: why would I want high bioavailability glutathione? The answer to this is very simple. Glutathione is regarded as the body's master antioxidant, and is crucial for controlling oxidative stress.* It is an endogenous compound of which we have large stores throughout the body, and many environmental and lifestyle stressors can deplete glutathione. In addition to this, as we age, glutathione levels start to plummet. With this in mind, it is a good idea for practically anyone to be topping off their glutathione levels, and what better way to do this than with an optimized version of glutathione?*
S-Phenylacetyl L-Glutathione is a phenylacetylated version of the endogenous tripeptide glutathione. Through the addition of a phenylacetyl group, S-Phenylacetyl L-Glutathione achieves higher bioavailability as it can reach cells in higher concentrations than regular reduced glutathione can achieve.*
It goes without saying that glutathione is one of the most important endogenous compounds in our bodies. It is found in high concentrations practically in every tissue and cell, and is particularly high in our livers, lungs and brains. Due to its importance, we also burn through large amounts of reduced glutathione on a daily basis, especially when we really need it, for example in cases of increased oxidative stress and under conditions of increased strain on the immune system. This is quite a lot of responsibility for a single compound, but luckily this mighty molecule is up to the task! However, despite the prowess of glutathione, it could use a bit of a helping hand replenishing some of its fallen comrades!
Two of the most common ways of increasing glutathione stores, is by supplementation with cysteine containing compounds or simply supplementing with reduced glutathione. If we utilize the correct dose of reduced glutathione (500-1,000 mg), then we can quite reliably increase our glutathione stores. However, we have to utilize a fairly high dose, because reduced glutathione does not have the best bioavailability. This is where S-Phenylacetyl L-Glutathione comes in! By attaching a phenylacetyl group to glutathione, we essentially create an enhanced precursor for glutathione. This means that S-Phenylacetyl L-Glutathione doesn’t have direct effects, it first needs to be converted to regular glutathione. However, the phenylacetyl group also pulls off a nice little trick, it allows itself to become hydrolyzed by the same enzymes that would normally break down glutathione. This means that S-Phenylacetyl L-Glutathione has a much better chance of getting glutathione into the cells before it is broken down extracellularly. Research studies have backed this up, and indicate much higher cellular uptake of glutathione when utilizing S-Phenylacetyl L-Glutathione.
So we have great bioavailability locked down, now what about the S-Phenylacetyl L-Glutathione benefits you can expect to experience? S-Phenylacetyl L-Glutathione will provide all of the glutathione benefits we are used to, but with the distinct advantage of higher bioavailability. By enhancing glutathione status with S-Phenylacetyl L-Glutathione, you can expect higher concentrations of glutathione primarily in your liver and lungs, which is where glutathione is often needed the most as a protective factor. With this in mind S-Phenylacetyl L-Glutathione can be a great strategy for helping to enhance liver and respiratory function.*
The more straightforward benefit we need to look at however, is glutathione ability to manage oxidative stress. Since glutathione is often seen as the body’s master antioxidant, it is no surprise that topping off its levels positively impacts oxidative status. When oxidative stress is under control, our mitochondria have an easier time producing energy, our cells are happier, our skin looks smoother, we are protected a little bit more from oxidation and our brains are nice and protected too! This actually brings us to another interesting glutathione benefit, enhanced cognitive function! While there is no specific research looking at S-Phenylacetyl L-Glutathione and cognitive function, it does seem logical that the phenylacetyl group would help shuttle glutathione to cells in the brain. In addition to this, we have seen some famous nootropics sporting this same phenylacetyl group, so perhaps S-Phenylacetyl L-Glutathione has some undiscovered cognitive benefits up its sleeve!*
Now that we have a full line up of glutathione supplements, a comparison is in order! Starting with the simplest glutathione supplement, reduced Glutathione is a fantastic option if you have patience and are ok with higher doses. Reduced glutathione needs to be taken in the 500-1,000 mg range, and glutathione levels will not significantly increase right away. You need to take reduced glutathione for at least a couple of weeks, before your reduced glutathione levels are significantly increased.* However, this also makes reduced glutathione a great option for those that are purely interested in keeping their glutathione reserves topped up long term.*
That brings us to S-Acetyl L-Glutathione which has significantly better bioavailability, and is amongst the very best glutathione supplements.* The primary benefit here too, is that S-Acetyl L-Glutathione can acutely raise glutathione levels, which sets it apart from reduced glutathione.* S-Acetyl L-Glutathione also does a great job of getting glutathione to where we need it most, and with the increased speed of raising glutathione levels, this makes S-Acetyl L-Glutathione a top choice if you need significant results quickly!*
Last but certainly not least, S-Phenylacetyl L-Glutathione! This form of glutathione is very similar to S-Acetyl L-Glutathione, only just slightly losing out on total absorption. However, due to the unique phenylacetyl group, we predict that S-Phenylacetyl L-Glutathione may have unexplored nootropic potential. So, if you are looking for a potentially nootropic glutathione supplement, then S-Phenylacetyl L-Glutathione is the one for you!*
Oxidative Status Stack: S-Phenylacetyl L-Glutathione + R-ALA Cyclodextrin Complex Tablets
When thinking of what to stack with something as cutting edge as S-Phenylacetyl L-Glutathione, it only made sense to stack it with a similarly cutting edge ingredient, cyclodextrin ALA. ALA is also a very important oxidation regulating compound, which also appears to have a positive impact on glutathione status. When combining the two, you should have one of the better stacks for dealing with oxidative stress!*
Cognitive Function Stack: S-Phenylacetyl L-Glutathione + OmegaTAU Capsules
Since S-Phenylacetyl L-Glutathione enhances cognitive function by providing an endogenous compound, it made a lot of sense to pair this with another nootropic that is built around enhancing endogenous compounds like choline and uridine. Taking OmegaTAU and S-Phenylacetyl L-Glutathione together should make for a very cutting edge, yet very natural way to increase cognitive function.*
Respiratory Support Stack: S-Phenylacetyl L-Glutathione + Andrographis paniculata Capsules
Glutathione plays a major role in supporting respiratory function, and Andrographis paniculata is a herb that has a profound impact on respiratory function too. With this in mind, it made sense to focus on the respiratory function support benefits of S-Phenylacetyl L-Glutathione, and increasing this effect with the inclusion of Andrographis!*
As a dietary supplement, take one 100mg capsule of S-Phenylacetyl L-Glutathione daily.
To gain more insight, see the S-Phenylacetyl L-Glutathione reviews and experiences below.
Nootropics Depot offers 60ct. or 180ct. jars of high-quality S-Phenylacetyl L-Glutathione. Nootropics Depot’s S-Phenylacetyl L-Glutathione has been lab-tested and verified for both product purity and identity.
| *Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. |
Absolutely amazing. My dad has been miserable ever since his glutathione infusions stopped as a result of his provider's retirement. This is the first version of oral glutathione that has helped. We saw more energy within the first few days, and a month later he is doing better than he has in several years.
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