About Sesame Extract Powder

Sesame Extract Powder delivers 70% sesamins, powerful lignan compounds extracted from sesame seeds and standardized for maximum bioactivity. These natural compounds support healthy oxidation levels, promote cognitive function, and help maintain balanced metabolic function.

Our Sesame Extract Story

Sesame seeds contain some of nature's most potent lignans, but most extracts on the market lack proper standardization. Without knowing exactly how much active sesamin you're getting, achieving consistent results or replicating promising research findings becomes impossible.

We developed a rigorously standardized extract that guarantees 70% minimum sesamin content through analytical testing. This high-potency standardization ensures you receive therapeutic levels of the specific lignans that research shows regulate fatty acid metabolism, support healthy vitamin E utilization, and promote balanced inflammatory responses throughout the body.

Benefits

• Supports Healthy Oxidative Balance: Sesamins help regulate oxidation levels in the body by influencing key metabolic pathways, including the rate-determining step in vitamin E metabolism, which enhances vitamin E retention and promotes cellular protection.
• Supports Healthy Metabolic Function: These lignans regulate delta-5-desaturase enzyme activity, which controls fatty acid metabolism speed and helps maintain healthy arachidonic acid levels for optimal metabolic function.
• Supports Cardiovascular Health: Sesame extract promotes balanced inflammatory responses and supports healthy lipid metabolism, contributing to overall cardiovascular wellness through multiple complementary mechanisms.
• Supports Healthy Neuronal Function: Research shows sesamins promote neuroprotection and support balanced brain inflammation levels, helping maintain optimal cognitive performance and neuronal health.

Sesame extract's unique ability to enhance vitamin E bioavailability creates synergistic effects throughout the body. By slowing vitamin E degradation, sesamins help maximize this essential nutrient's protective functions across multiple organ systems, supporting comprehensive wellness from cellular to systemic levels.

Quality and Standardization

• 70% Sesamins Standardization: Our Sesame Extract is precisely standardized to deliver a minimum of 70% sesamins by weight, ensuring consistent levels of these bioactive lignan compounds in every serving.
• UPLC Testing Verification: We utilize advanced Ultra Performance Liquid Chromatography (UPLC) testing methods to verify the exact sesamin content and confirm the absence of contaminants in our extract.
• Lab-Tested Purity: Each batch undergoes comprehensive third-party testing for both product purity and identity verification, meeting our strict quality standards before release.
• Premium Extraction Process: Our sesame seeds are processed using specialized extraction techniques that concentrate the beneficial lignan compounds while maintaining their natural bioactivity and stability.
• cGMP Manufacturing Standards: Produced in FDA-registered, cGMP-certified facilities in the USA to ensure pharmaceutical-grade quality control throughout the manufacturing process.

Mechanism of Action

• Fatty Acid Metabolism Regulation: Sesamins regulate delta-5-desaturase enzyme activity, which controls the rate of fatty acid metabolism and helps maintain lower arachidonic acid levels in the body.
• Vitamin E Preservation: These lignans inhibit tocopherol-omega-hydroxylation, the rate-determining step in vitamin E metabolism, potentially enhancing vitamin E retention and extending its protective effects in cellular membranes.
• Neuroprotective Signaling: Animal studies suggest sesamins support neuroprotection through modulation of inflammatory pathways and anti oxidative stress supplements mechanisms in brain tissue.
• Cellular Protection Pathways: Sesamins work at the cellular level to support balanced oxidative responses and promote healthy inflammatory signaling cascades throughout the body.

Overview of the Science

Research demonstrates that sesamins influence several key metabolic pathways involved in oxidative balance and longevity. Studies have shown that sesamin supplementation appears to regulate liver enzyme activity, particularly affecting fatty acid oxidation and synthesis pathways [1]. This metabolic modulation extends to lipid profile improvements, where clinical trials have documented significant changes in cholesterol and triglyceride levels following sesamin intake [2]. The compound's ability to cross the blood-brain barrier and accumulate in neural tissue has been demonstrated in animal models, suggesting potential neuroprotective mechanisms through antioxidant and anti-inflammatory pathways [4][5].

Emerging research indicates that sesamins may support cellular health supplements through their interaction with nuclear receptors and transcription factors involved in cellular energy production. Studies suggest that these lignans can influence mitochondrial function and may help maintain cellular energy metabolism under various stress conditions [6][7]. Human trials examining cognitive function have reported improvements in certain memory parameters when sesamin was administered as part of a composite supplement regimen, though more targeted research is needed to establish definitive cognitive benefits [5].

[1] Zhou ZQ, Gu LJ, Yang XN, Zhou TH, He XH, Lu HJ, Zheng QH, Tang QZ. J Nutr. 2023;153(1):139-153.

[2] Helli B, Shahi MM, Mowla K, Jalali MT, Haghighian HK. Phytother Res. 2022;36(3):1425-1435.

[4] Wu H, Wang Q, Kang W, Liu R, Tang M, Zhang H. Mol Cell Biochem. 2022;477(8):2007-2018.

[5] Ito N, Saito H, Seki S, Ueda F, Asada T. J Alzheimers Dis. 2018;62(4):1767-1775.

[6] Kong M, Lee Y, Kang S, Cho S, Park J. Molecules. 2023;28(21):7255.

[7] Naito Y, Shimozawa M, Kuroda M, Nakabe N, Manabe H, Katada K, Kokura S, Ichikawa H, Yoshida N, Noguchi N, Yoshikawa T. Hepatogastroenterology. 2003;50(54):1609-1613.

Ingredients

Sesame Extract Powder (Sesamum indicum):

• Standardized to 70% sesamins by weight
• 200mg per serving
• Contains additional lignans including sesaminol, sesamolin, and sesamol

Our 70% sesamin standardization represents one of the highest concentrations available, ensuring you receive therapeutic levels of these bioactive lignans in each dose. This precise extraction process concentrates the most researched compounds from sesame seeds while maintaining the natural lignan profile that makes this anti oxidative stress supplement so effective. The 200mg serving size provides an optimal balance between efficacy and safety, delivering the same amounts used in clinical research studies.