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Tetrahydromagnolol Tablets

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Dietary Restrictions:
Lactose Free
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Gluten Free
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Non-GMO
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Tablets
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lab-testing:
TETCS1012624A | TETCS1012624A_60ct_signed.pdf
lab-testing:
TETCS1072523 | TETCS1072523_180ct_signed.pdf
lab-testing:
TETCS1091123 | TETCS1091123_60ct_signed.pdf
lab-testing:
TETCS1020624 | TETCS1020624_60ct_signed.pdf
$29.99
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Why Should I Take Tetrahydromagnolol?

Tetrahydromagnolol is a cutting edge derivative of one of the main bioactives in magnolia bark, magnolol. Tetrahydromagnolol is a major metabolite that gets formed after magnolol is orally supplemented, and presents with a very interesting effects profile! However, the metabolism of magnolol is unpredictable, and thus we have taken the guesswork out of it, and hydrogenated magnolol in order to create pure tetrahydromagnolol. This compound now can get to work fast, and exert potent effects!

Tetrahydromagnolol is fascinating because it has significant agonist effects at the cannabinoid CB2 receptor and mild agonist effects at the cannabinoid CB1 receptor. Additionally, it also acts as a significant antagonist at the novel GPR55 cannabinoid receptor. These receptor targets produce a very interesting effects profile that is rarely seen, and offer unique effects on pain management, inflammation, gastrointestinal health, and mood!

We should also mention that tetrahydromagnolol is incredibly rare! It took us years to develop this product, and as of 2023, we are the only vendor that carries this unique compound!

What is Tetrahydromagnolol?

Tetrahydromagnolol is one of the primary metabolites of magnolol, which is a highly bioactive lignan found in the bark of Magnolia officinalis. When magnolol is taken orally, it becomes metabolized by various enzyme systems, which then yields tetrahydromagnolol as one of the primary metabolites. Tetrahydromagnolol is even more bioactive, and most interestingly becomes a much more potent and selective cannabinoid CB2 agonist!

That being said, tetrahydromagnolol formation in humans after oral administration of magnolol, is not going to be very efficient. First of all, a large portion of magnolol is excreted unchanged, which drastically reduces the potential for tetrahydromagnolol formation. Furthermore, tetrahydromagnolol is only one of a few possible magnolol metabolites, and the metabolism is being facilitated by highly variable enzyme systems. Due to this, the amount of tetrahydromagnolol formed after oral ingestion of magnolol is likely going to be fairly low. This is why “pre-metabolized” tetrahydromagnolol is very interesting, as you can immediately and reliably access the wonderful benefits of it!

Tetrahydromagnolol is made by a fairly lengthy process, starting with the harvesting of Magnolia officinalis bark. From the bark, we can extract and isolate magnolol. Once the magnolol has been highly purified, it is reacted with molecular hydrogen, in a process known as hydrogenation. This then removes the double bonds in magnolol, and yields tetrahydromagnolol!

Tetrahydromagnolol Benefits & Uses

    • Promotes pain management
    • Enhances mood
    • Promotes gastrointestinal comfort

Next Generation Magnolia Bark

Magnolia bark is well known for its ability to induce relaxation, boost mood and modulate pain. These effects can be attributed to two different compounds, magnolol which is more active on the endocannabinoid side, and honokiol which is more active on the GABAergic side. When either of these compounds are hydrogenated, their respective affinities drastically increase. For tetrahydromagnolol, this means that it is about 19 times more active at the CB2 receptor than its parent compound, magnolol. So what does this mean in terms of effects?

The CB2 cannabinoid receptor is a very unique receptor which is widespread throughout our body and central nervous system. Within our body, it interacts a lot with immune cells, especially those which control inflammation. In fact, there is a particularly high concentration of CB2 receptors in the gastrointestinal tract, and due to this, CB2 agonists have the ability to greatly dampen inflammation throughout the gastrointestinal tract. Natural CB2 agonists are fairly hard to come by though, especially those which possess high potency like tetrahydromagnolol. Interestingly enough, within traditional Chinese practices, Magnolia officinalis bark has been used for centuries for alleviating gastrointestinal distress! Thus, based on the pharmacological enhancement of magnolol activity via hydrogenation, tetrahydromagnolol should be a fantastic ally for those looking to enhance gastrointestinal comfort, via its potent CB2 agonist effects!

Another use for Magnolia officinalis bark in both traditional Chinese and Japanese practices, has been to use it for pain. This is interesting, because CB2 receptors have a potent regulating effect on pain signaling. With this in mind, the significant increase in CB2 affinity with tetrahydromagnolol, will make it a fantastic pain management supplement. Anecdotally, we have noticed robust pain management effects with tetrahydromagnolol which kick in quite rapidly. Research wise, there is a huge search for selective CB2 agonists, as they are non-psychoactive and can provide very significant pain regulating effects. Within this currently large body of research, there is also a lot of emphasis on CB2 agonists being particularly useful for nerve related pain.

On the topic of pain and research, there is currently also a lot of research ongoing on the GPR55 receptor. This is a novel cannabinoid receptor that was only discovered about two decades ago and there is still relatively little known about it. However, in the last few years, some relatively selective GPR55 ligands have demonstrated that antagonism of this receptor can also produce robust inflammation regulating effects. As luck would have it, tetrahydromagnolol is a relatively potent antagonist at the GPR55 receptor, which further adds to its pain management effects profile!

Another traditional use for Magnolia officinalis bark, has been for mood. Most of this activity likely is coming from the more GABAergic side of magnolia bark, however, the CB2 receptors can also control various aspects of mood. The bulk of these effects come from the fact that agonism of CB2 receptors in the brain produces a fantastic inflammation dampening effect. High levels of inflammation have been linked to low mood and can even have negative impacts on general cognitive function. Thus mitigating this with tetrahydromagnolol can produce a nice mood and cognition boosting effect!

Tetrahydromagnolol Stacks

CB2 Activator Stack: Tetrahydromagnolol + Rephyll Capsules

Since tetrahydromagnolol is a fantastic CB2 receptor agonist, it made perfect sense to combine it with a terpene called beta-caryophyllene, which also acts at CB2 receptors! Together, these two will provide the most pronounced CB2 focused effects, which can provide benefits for pain, mood, and gastrointestinal comfort.

Endocannabinoid Mood Stack: Tetrahydromagnolol + Maca Extract Capsules

The endocannabinoid effects of tetrahydromagnolol are fantastic for pain, however, it could use a bit of a helping hand when it comes to mood. Together with the FAAH inhibitor effects of maca, the mood effects become much more pronounced, resulting in a very nice creative mood lift!

Gastrointestinal Comfort Stack: Tetrahydromagnolol + Ginger Extract Capsules

The CB2 effects of tetrahydromagnolol have a fantastic effect on intestinal inflammation, which makes it a great option for promoting gastrointestinal comfort. This effect gets further elevated with ginger, which has for centuries been used for its positive gastrointestinal effects. The pair then makes for a very robust stack for all things gastrointestinal!

Tetrahydromagnolol Dosage

As a dietary supplement, take one 20mg tablet of Tetrahydromagnolol daily.

Tetrahydromagnolol Reviews

To gain more insight, see the Tetrahydromagnolol reviews and experiences below.

Where to Buy Tetrahydromagnolol

Nootropics Depot offers 60ct. or 180ct. jars of high-quality Tetrahydromagnolol. Nootropics Depot’s Tetrahydromagnolol has been lab-tested and verified for both product purity and identity.

Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Reviews

  • 5
    Worth every penny!!!

    Posted by Quinton Walker on 26th Nov 2023

    Okay, so I have extremely bad insomnia. I have trouble falling asleep and also staying asleep, as I wake up throughout the night often. I’ve tried the magnolia bark extract and it’s great, but let me tell you this is hands down better. I can feel the gabaergic effects of tetrahydromagnolol within an hour, which is astounding. This is one of the only supplements that very closely resembles a hypnotic or benzo and it has worked miracles for my sleep. I take 1 in the morning if I know there is a stressful day ahead and 1 at night to help with sleep and it helps tremendously. Thank you nootropics depot for producing the best quality nootropic products on the market. I will continue buying these, cause like the title of my review says, when your in need of some sound sleep, tetrahydromagnolol is worth every penny!!!

  • 5
    Whoa

    Posted by EM on 23rd Aug 2023

    I did not expect this to be so glorious. I take half at night and half in the morning and I am feeling much more capable. My stress can cause serious issues with cognitive functioning and I get overwhelmed quickly. This is helping. I’ll let y’all know in a few months how it’s going.

  • 5
    Game changing product for stress/sleep and many other benefits

    Posted by Matthew B on 11th Apr 2023

    As an avid nootropic enthusiast, I have been waiting with anticipation for Tetrahydromagnolol to arrive, especially after experiencing the benefits of Nootropics Depot's previous Magnolia Bark product. I must say, Tetrahydromagnolol exceeds all expectations and brings a plethora of powerful effects with a reduced body load compared to its predecessor. Tetrahydromagnolol is an isolated and refined compound from the Magnolia Bark, and its improved formulation ensures a more targeted and potent effect. The reduced body load is a standout feature, as it allows users to benefit from its therapeutic effects without feeling the weight or sluggishness that some may have experienced with the previous Magnolia Bark product. One of the most striking aspects of Tetrahydromagnolol is its remarkable flexibility in dosing. It shines at various dosage levels, making it suitable for a wide range of applications. At lower doses, such as 5mg and 10mg taken it provides subtle enhancements in mood, focus, and cognition. The effects are noticeable, but not overpowering, making it perfect for daily use and enhancing productivity. As the dosage increases to 20mg, 30mg, and even 40mg, Tetrahydromagnolol exhibits a more profound effect profile. It becomes an ideal supplement for managing stress, and promoting relaxation. The higher doses are particularly beneficial for those with demanding lifestyles or in high-pressure situations, offering an adaptive solution to the stressors that life may present. One of the unique features of Tetrahydromagnolol is its ability to boost REM sleep at lower doses. By taking a smaller dose before bedtime, I found that it significantly improved the quality of my sleep. Not only did I wake up feeling more refreshed and rejuvenated, but I also noticed a marked increase in dream vividness and recall. This aspect makes Tetrahydromagnolol an invaluable addition to any sleep regimen. In summary, Tetrahydromagnolol is a game-changer in the realm of nootropics. With its powerful effects, reduced body load, and versatile dosing options, it stands out as a truly remarkable product. Whether you're looking to improve your cognitive performance, reduce stress, or enhance the quality of your sleep, Tetrahydromagnolol is an excellent choice. I wholeheartedly recommend it to anyone seeking a versatile and effective nootropic supplement

  • 5
    Works

    Posted by Derek on 15th Mar 2023

    Definitely works on me. Quick and noticeable

  • 5
    Shocked by how great this product is

    Posted by Kevin P on 2nd Mar 2023

    I regularly experience gastrointestinal discomfort which also has an affect on my overall mood. So I have been seeking other alternatives for pain and inflammation. CBD/CBG do work for things like pain and inflammation, but WOW this stuff might be even more affective for me. It also alleviates my gastrointestinal discomfort and quickly elevates my mood for hours to come. I definitely was not expecting to get so much out of this. I will definitely be adding this to my daily stack going forward!

  • 5
    Shocked by how great this product is

    Posted by Kevin P on 2nd Mar 2023

    As someone with gut issues, I regularly experience gastrointestinal discomfort which also has an affect on my overall mood. I recently stopped using other alternatives, but WOW this stuff might be even more affective for me. It also alleviates my gastrointestinal discomfort and quickly elevates my mood for hours to come. I definitely was not expecting to get so much out of this. I will definitely be adding this to my daily stack going forward!

  • 5
    Worth a Try for Sure

    Posted by G on 21st Feb 2023

    I love this. I have chronic pain (back, neck, frequent sinus headaches from allergies) and this made a fast and noticeable difference on some pain. I did feel more chill myself but hard to say if it was a direct effect or just the knock-on effects of feeling less pain.

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*Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.