Uridine Monophosphate, often abbreviated to UMP, is a nucleotide base that acts as a monomer in RNA. You may also see Uridine Monophosphate also referred to as 5’-uridylic acid or uridine 5 monophosphate. It is a chemical compound derived from phosphoric acid and the nucleoside uridine and is used in the body to increase the forming of cellular membranes. When taken as a supplement, Uridine Monophosphate powder may offer several potential benefits to cognitive and physical health.*
There are several Uridine Monophosphate uses, and the body uses Uridine Monophosphate in various processes like signaling the creation of neurotransmitter synapses and helps promote DNA repair and the growth of cells. Uridine is one of the four major building blocks of RNA along with cytidine, guanine, and adenosine. Uridine is created in the liver in the Uridine Monophosphate form, which is then secreted into the bloodstream. In fact, Uridine Monophosphate is pretty concentrated in beer, breast milk, various plants, and even some infant formulas contain Uridine Monophosphate. Uridine can also be found in the Uridine Triphosphate form.
Uridine is believed to benefit synaptic functions by increasing phosphatidylcholine in the brain. Phosphatidylcholine is a critical component of dendritic membranes. Uridine also plays a role as a substrate in phosphatidylcholine (PC) synthesis through the CDP-choline pathway, also referred to as the Kennedy cycle. Phosphatidylethanolamine is also created in this pathway. This is important since phosphatidylethanolamine is a phospholipid that contributes to building brain cell membranes and plays a key role in neurotransmission.
Research has led scientists to believe that Uridine benefits synaptic functions via promoting phosphatidylcholine levels in the brain. Phosphatidylcholine is a key component of dendritic membranes and critical for their function. Uridine acts as a substrate during phosphatidylcholine (PC) synthesis through the CDP-choline pathway, also referred to as the Kennedy cycle. Phosphatidylethanolamine is also synthesized via this pathway. This is important since phosphatidylethanolamine is a phospholipid that helps promote the creation of brain cell membranes and plays a key role in neurotransmission.
In the Kennedy cycle, choline kinase catalyzes choline into phosphocholine consuming an ATP molecule in the process. This lets more cellular choline be converted into phosphocholine. Uridine research on rodents found that rodents appeared to show improved cognitive function when consuming a diet consisting of Uridine Monophosphate, choline and docosahexaenoic acid (DHA). Other studies discovered a positive influence on cognition when subjects were taking a Uridine DHA stack, meaning taking a uridine supplement and a DHA supplement together. Phosphatidylcholine is a phospholipid critical to synaptic function as well as beneficial to cellular health and function overall. Producing phosphatidylcholine requires CDP-choline, which requires uridine and cytidine. Conveniently, uridine can be converted into cytidine in the body, making this process much easier.
Uridine Monophosphate carries a variety of potential benefits to the body and mind. Studies have observed that Uridine Monophosphate may promote memory and learning by increasing acetylcholine production. Acetylcholine is a prominent neurotransmitter. UMP may also help promote the formation of new neural synapses, which may support greater mental capacity. Results from uridine studies suggest that Uridine Monophosphate may help promote attention span and spatial learning. This may be a result of the compound’s impact on certain neurotransmitters associated with mood, motivation, and attention span. Uridine Monophosphate may also support restful sleep. Rat studies found that uridine increased slow-wave, or deep sleep particularly in sleep deprived rats. Preliminary studies show that slow-wave sleep is needed to help the brain’s recovery process from daily activities. Thus, this may be an indirect way that Uridine Monophosphate takes to help promote cognition.
If you have been around the nootropic space for a while, you may have read about the Mr. Happy stack. The Mr. Happy stack is a combination of Uridine, fish oil, and a choline source:
Uridine Monophosphate: Helps promote neuroplasticity whilst supporting our brain membranes.*
Triple Strength Fish Oil: The high DHA content of this budget friendly fish oil, works hand in hand with Uridine Monophosphate to help support brain membranes. This combined action helps solidify the already fantastic cognition promoting effects of Uridine Monophosphate!*
Alpha-GPC: A source of Choline really helps tie this stack together, helping to push the memory promoting effects of this stack to the next level. Alpha GPC is a great choice for a Choline source because it makes its way to the brain very readily.*
If you like this stack, you should check out our stack guides, which feature over 70 different stacks like this! Pro-tip, look under the “memory support” section of the ‘advanced stacks’ portion of the stack guide for a novel twist on this classic stack!
As a dietary supplement, take 250mg of Uridine Monophosphate once daily.
To learn more, read the Uridine Monophosphate reviews and experiences below.
Nootropics Depot offers 30g or 60g jars of high quality Uridine Monophosphate powder (Disodium Salt). Nootropics Depot's Uridine Monophosphatehas been lab-tested and verified for both product purity and identity.
| *Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
