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Uridine Monophosphate Powder (Disodium Salt)

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Uridine Monophosphate
30g or 60g
120 Servings or 240 Servings
As a dietary supplement, take 250mg of Uridine Monophosphate daily.
Store in a cool and dry place. Keep away from direct sunlight and heat.
Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drugs or over the counter medications.
Always consult with a qualified health physician before taking any new dietary supplement. This product is not intended to diagnose, treat, cure, or prevent any diseases. These statements have not been evaluated by the Food and Drug Administration.

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Uridine Monophosphate Powder

What is Uridine Monophosphate Powder?

Uridine Monophosphate, often abbreviated to UMP, is a nucleotide base that acts as a monomer in RNA. You may also see Uridine Monophosphate also referred to as 5’-uridylic acid or uridine 5 monophosphate. It is a chemical compound derived from phosphoric acid and the nucleoside uridine and is used in the body to increase the forming of cellular membranes. When taken as a supplement, Uridine Monophosphate powder may offer several potential benefits to cognitive and physical health.

There are several Uridine Monophosphate uses, and the body uses Uridine Monophosphate in various processes like signaling the creation of neurotransmitter synapses and helps promote DNA repair and the growth of cells. Uridine is one of the four major building blocks of RNA along with cytidine, guanine, and adenosine. Uridine is created in the liver in the Uridine Monophosphate form, which is then secreted into the bloodstream. In fact, Uridine Monophosphate is pretty concentrated in beer, breast milk, various plants, and even some infant formulas contain Uridine Monophosphate. Uridine can also be found in the Uridine Triphosphate form.

Uridine Monophosphate Benefits and Uses

    • May help support cognitive function
    • May help promote healthy sleep patterns
    • May help support working memory
    • May help promote neurotransmission

Understanding Uridine Monophosphate

Uridine is believed to benefit synaptic functions by increasing phosphatidylcholine in the brain. Phosphatidylcholine is a critical component of dendritic membranes. Uridine also plays a role as a substrate in phosphatidylcholine (PC) synthesis through the CDP-choline pathway, also referred to as the Kennedy cycle. Phosphatidylethanolamine is also created in this pathway. This is important since phosphatidylethanolamine is a phospholipid that contributes to building brain cell membranes and plays a key role in neurotransmission.

Research has led scientists to believe that Uridine benefits synaptic functions via promoting phosphatidylcholine levels in the brain. Phosphatidylcholine is a key component of dendritic membranes and critical for their function. Uridine acts as a substrate during phosphatidylcholine (PC) synthesis through the CDP-choline pathway, also referred to as the Kennedy cycle. Phosphatidylethanolamine is also synthesized via this pathway. This is important since phosphatidylethanolamine is a phospholipid that helps promote the creation of brain cell membranes and plays a key role in neurotransmission.

In the Kennedy cycle, choline kinase catalyzes choline into phosphocholine consuming an ATP molecule in the process. This lets more cellular choline be converted into phosphocholine. Uridine research on rodents found that rodents appeared to show improved cognitive function when consuming a diet consisting of Uridine Monophosphate, choline and docosahexaenoic acid (DHA). Other studies discovered a positive influence on cognition when subjects were taking a Uridine DHA stack, meaning taking a uridine supplement and a DHA supplement together. Phosphatidylcholine is a phospholipid critical to synaptic function as well as beneficial to cellular health and function overall. Producing phosphatidylcholine requires CDP-choline, which requires uridine and cytidine. Conveniently, uridine can be converted into cytidine in the body, making this process much easier.

Uridine Monophosphate Research 

Uridine Monophosphate carries a variety of potential benefits to the body and mind. Studies have observed that Uridine Monophosphate may promote memory and learning by increasing acetylcholine production. Acetylcholine is a prominent neurotransmitter. UMP may also help promote the formation of new neural synapses, which may support greater mental capacity. Results from uridine studies suggest that Uridine Monophosphate may help promote attention span and spatial learning. This may be a result of the compound’s impact on certain neurotransmitters associated with mood, motivation, and attention span. Uridine Monophosphate may also support restful sleep. Rat studies found that uridine increased slow-wave, or deep sleep particularly in sleep deprived rats. Preliminary studies show that slow-wave sleep is needed to help the brain’s recovery process from daily activities. Thus, this may be an indirect way that Uridine Monophosphate takes to help promote cognition.

Uridine Monophosphate Stack

If you have been around the nootropic space for a while, you may have read about the Mr. Happy stack. The Mr. Happy stack is a combination of Uridine, fish oil, and a choline source:

Uridine Monophosphate: Helps promote neuroplasticity whilst supporting our brain membranes.  

Triple Strength Fish Oil: The high DHA content of this budget friendly fish oil, works hand in hand with Uridine Monophosphate to help support brain membranes. This combined action helps solidify the already fantastic cognition promoting effects of Uridine Monophosphate! 

Alpha-GPC: A source of Choline really helps tie this stack together, helping to push the memory promoting effects of this stack to the next level. Alpha GPC is a great choice for a Choline source because it makes its way to the brain very readily. 

If you like this stack, you should check out our stack guides, which feature over 70 different stacks like this! Pro-tip, look under the “memory support” section of the ‘advanced stacks’ portion of the stack guide for a novel twist on this classic stack!

Uridine Monophosphate Dosage

As a dietary supplement, take 250mg of Uridine Monophosphate once daily.

Read Uridine Monophosphate Reviews

To learn more, read the Uridine Monophosphate reviews and experiences below.

Where to Buy Uridine Monophosphate?

Nootropics Depot offers 30g or 125g jars of high quality Uridine Monophosphate powder (Disodium Salt). Nootropics Depot's Uridine Monophosphatehas been lab-tested and verified for both product purity and identity.

Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated by the FDA.

26 Reviews

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  • Greg Lee - 25th Jul 2020

    Uridine Monophosphate

    This stuff is pretty good taken with fish oil. It wasn't quite what I was expecting after hearing of the "Mr. Happy Stack" but it's definitely worth a try.

  • Matthew S Gruby - 1st Jul 2020

    The best

    Excellent products as always

26 Reviews

  • Greg Lee - 25th Jul 2020

    Uridine Monophosphate

    This stuff is pretty good taken with fish oil. It wasn't quite what I was expecting after hearing of the "Mr. Happy Stack" but it's definitely worth a try.

  • Matthew S Gruby - 1st Jul 2020

    The best

    Excellent products as always

  • Jessica - 7th Jan 2020

    A cognitive performance must

    I work as a neuroscientist and take this every morning before work. Tt definitely makes a difference in my cognitive performance.

  • Thom Willson - 29th May 2019

    No Difference

    I can only assume it's because I'm not as conducive to the power of suggestion/placebo as others that I haven't felt any difference taking at LEAST 200mg of this a day for the past week. Maybe I'm supposed to avoid all other possible stimulants in the morning, such as coffee or tea or energy bars...but what's the point of that? Those are enjoyable nourishment that clearly provide better energy, focus, and drive than I can tell this stuff does. Guess I'll up the dosage - even though I'm only 170lbs - and see where the threshold is for actually feeling it, even if that means "overdoing"/feeling bad from it. ND Admin: This is not a stimulant. I am not sure where you got the idea this is supposed to replace tea or energy bars. Uridine is a cofactor in many processes in the body. It enhances acethylcholine production, improves phospholipid content in your cell membranes, up-regulates dopamine, and promotes the formation of new neuronal synapses. It's not a stimulant. In fact, it can improve sleep quality. It should not be used as a replacement for tea or energy drinks, nor are you going to strongly "feel" it on its own. It is most often used as part of a stack, like the uridine/DHA stack, also known as the Mr. Happy stack. This is more for memory and mood improvements over time, not energy.

  • Mat - 24th Apr 2019

    Mood and Focus

    Taking 100-200 mg sublingually you can notice a real difference. One of the few Nootropics that has any perceptible change for me. I am able to home in on thoughts and ideas more clearly. I also notice more interest and contentment with my activity at the time. One of my morning favorites.

  • Thomas Colodel - 3rd Mar 2019


    Improved my logic memory (more easy to my memory to memorise efficiently different patterns with slight differences each other). Mood has improved to a good level too.

  • Tim - 28th Jan 2019

    mental confusion in a tub

    No matter how many times I tried this with the correct cofactor supplements or even trying the mr. Happy stack approach, it did not work and made me feel anxious. I don't recommend it.

  • Unknown - 6th Oct 2018

    Amazing Product!

    I’ve used Uridine Monophosphate with great results. My mood began to improve, memory was better, and overall sense of well-being began to subtly shift towards the positive! Ordered it again from the trusted source of Nootropics Depot, and was not left with a bad product; they delivered on time, good packaging, and high-quality product overall!

  • Ali - 19th Sep 2018

    Excellent Uridine

    Great quality Uridine at an affordable price, what I would expect from Nootropics Depot's dedication to quality and testing

  • Colin Boda - 3rd Aug 2018

    Happy with it.

    Came quickly altogether and packaged professionally.

  • Unknown - 11th Jun 2018

    Uridine Monophosphate

    Fast postage, good packaging.......a little bit costly......yet to begin taking

  • Peter - 29th Apr 2018

    lack of expiration date

    We need to add expiration date on the package label. It must be included on label in order to be able to continue ordering. Thanks ND Admin: FDA regulations stipulate that an expiration date should only be put on a label if you have scientific evidence of its accuracy. Most places just slap a 3 year date on it and call it a day. That's actually against FDA regulations. The last 4 digits of your lot number is the production date of your bottle, though. So if you are concerned about how old the product is, that gives you that info. However, we go through our inventory so fast. Most products completely cycle through lots in a matter of months.

  • Tristan Michael Strejc - 11th Mar 2018

    Good stuff. Easy to use.

    I have been taking little scoops a couple times a day under my tongue. It dissolves pretty fast. Doesnt taste bad, just salty. I think i have noticed improved memory after taking it for about 2 weeks with fish oil.

  • disciple111 - 17th Feb 2018

    part of my daily stack.

    since uridine is a naturally occurring compound in my body I am choosing to use it as a neuro-protectant as i continue into my early 70's along with a variety of other nootropics. Easy to take and the taste is ok and I have tasted some truly nasty supplements.

  • Unknown - 3rd Feb 2018

    great addition to stack

    love this stuff, helps me sleep better, and just overall balances my energy levels and thought processes in a way I think

  • Barak Skop - 9th Dec 2017

    Not much noticeable effect but...

    I take in small doses everything, and this has maybe helped me a little with concentration

  • Raiden - 25th Oct 2017

    Amazing quality/price

    The products is so pure and effective when you compare it to its price Its really hard to find good quality these days even if you put more money, but ND's quality is unquestionable. (ND, please don't change your supplier)

  • Chris - 3rd May 2017

    a surprising benefit from such a small dose.

    Someone on reddit told me to look into the "Mr. Happy" uridine stack. A stack designed to counterbalance the negative side effects of long term stimulant use. The reason I quit was due to the fact that I felt like it was making me feel retarded and i still couldn't focus. So i started taking uridine and fish oil and introduced alpha gpc, and honestly its been night and day. I feel better overall, i feel happier, and i really feel like a normal human being, which wasnt the case pre stimulant. Nootropics depot sent the packages out quickly, packaged safely for shipping and seem to be of really great quality

  • Unknown - 1st May 2017


    quality product at decent price

  • Unknown - 25th Apr 2017


    Good packaging, quick shipping. Changes are subtle but noticeable. Been taking for around 3 months, 300mg twice daily..along w fish oil, b12, methylfolate.