Self
Helped me with my treatment-resistant mood issues in conjunction with TMS.
7,8-Dihydroxyflavone, also known as 7,8-DHF, is a natural flavone found in a number of species that can reach the brain and exert cognitive effects. It binds to the TrkB receptors in a similar way to BDNF, or brain derived neurotrophic factor. When the TrkB receptor is activated, neuroprotective and neurogenetive effects occur in neurons, which tend to affect the dendrites. Dendrites are what reach out from the neurons into the synapse to participate in signaling with other neurons. 7,8-DHF has been shown to promote the growth of these dendrites, and to help restore communication between neurons in animal models. Other natural extracts, like polygala tenuifolia and bacopa monnieri work in a similar fashion, but rather than binding directly to the TrkB receptor, they cause a release in BDNF, which then binds to the receptor. 7,8-DHF has also demonstrated a protective effect against apoptosis. 7,8-DHF can cross the blood brain barrier, and act directly on brain TrkB receptors; which is something that peripheral administration of BDNF cannot do. As such, it is a very promising natural compound for cognitive function.
As a dietary supplement, take 25mg of 7,8 DHF 1-2 times daily. It appears to be subject to extensive first-pass metabolism in the liver. Due to improved bioavailability, sublingual administration (under the tongue) may be preferred.
To gain more insight about 7,8 DHF, read the 7,8-Dihydroxyflavone reviews and experiences below.
Nootropics Depot offers 1 gram, 2 gram or 5 gram jars of 7,8 DHF Powder. Nootropics Depot's 7,8 Dihydroxyflavone powder has been lab-tested and verified for both product purity and identity.
Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Helped me with my treatment-resistant mood issues in conjunction with TMS.
I find that I'm incredible emotionally stable seemingly no matter what is stressing me. I've been dosing 30-40mg
Helped me with my treatment-resistant mood issues in conjunction with TMS.
I find that I'm incredible emotionally stable seemingly no matter what is stressing me. I've been dosing 30-40mg
Good material . Dosage of 50-100mg. My stacks are pretty complex and ever-changing so sometimes tough to get a read on effects of specific substance but seem to have experienced some good effects. I have ordered material from Nootropics Depot a few times now and very impressed with quality , service and good selection of interesting and relevant products.
Unfortunately I was unable to notice any difference in memory, intuition, reaction processing or comprehension after 5 months of supplementation at the recommended dosages. I really was hoping to have discovered the proverbial 'fountain of youth', but for me, I was unaffected. I wish i could leave a comment without a rating, but since I cannot I did rate it 5 stars. I hope that my experience doesn't jade anyone else's opinion regarding 7,8-DiHdroxy, since so many have had a very positive outcome with this flavone.
so, I just put this powder under the tongue? or is a different product for sublingual ND Admin: Yes, this can be used sublingually.
I am blown away by its emotional naturalizing effect. otherwise I have problems addressing issues that are emotionally stressing. But this compound removes the apathy or the unwillingness to deal with the stuff that causes stress.
It has kept my "central sleep apnea" under control. Darn near cured it! Sublingual use of 25mg! prior to sleeptime.
7,8 dhf has exceeded my expectations. If you are feeling in a funk this can help get through it
I was not sure if the placebo effect was going on the first day. But after a couple days, I have noticed memory recall to be better. I also had better focus and did not find myself bouncing around to a bunch of misc. tasks and was able to focus on the task at hand. I am not sure about tolerance yet, but I will probably only use on the days I really need to get stuff done. Seems to be a great add-on to my other stacks
