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Dose
200mg (One Capsule)
Dose Timing
Flexible
How to Take
With Or Without Food
Dose Frequency
1 Time Daily
Apigenin is a natural flavonoid that improves mood, balances inflammation, supports metabolic function, and helps manage stress, making it a versatile supplement for overall well-being and emotional balance.
Time to notice full effects: 3-4 Weeks (With Immediate Effects)
Mood
Inflammation
Metabolism
Stress
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Apigenin is a flavone found in many different plant species, with notable plants including chamomile and parsley, but it is also found in Baikal skullcap for example. In fact, our Baikal Skullcap extract actually contains 15% apigenin! Apigenin is well known for its sleep promoting effect and supportive effects for cognitive function, digestive function, balanced oxidation levels and cellular function. Keep on reading to find out more about this awesome supplement!
While Apigenin can also be found in many of the foods that we consume on a daily basis, such as celery and oranges, the levels that can be found in our diet don’t come anywhere near the levels we are able to achieve with 98% pure apigenin supplementation! So if you are looking to get the most out of apigenin, then keep on reading.
Apigenin recently garnered a whole lot of attention when it was discussed it in some popular podcasts. Indeed, apigenin is a great compound that can be taken close to bedtime to help with sleep due to its GABAergic effects. It is likely then also not a surprise that one of the compounds within chamomile that contributes to the relaxation and sleep promoting effects, is apigenin. The sleep promoting effects of apigenin may however take a little while to fully develop, similar to how the memory promoting effects of Bacopa monnieri can take a few weeks. The reason this appears to be the case with apigenin, is because it upregulates a very important enzyme necessary for GABA synthesis, glutamate decarboxylase (GAD67). GAD67 catalyzes the reaction that turns glutamate into GABA. In fact, the majority of GABA is produced through this GAD67 mediated pathway, and thus it is no surprise that apigenin can help with sleep, as GABA is a major player when it comes to inducing sleep. However, it also makes sense that these effects may take a while to develop, since we are relying on enzyme upregulation which is often a very slow process, albeit a very rewarding process!
The GAD67 upregulating effects also extend to apigenins relaxation inducing effects. GABAergic effects also mediate the majority of the relaxing effects we all know and love, and since we are overtime upregulating one of the main GABA producing pathways, apigenin is a fantastic long term solution for promoting everyday relaxation.
The fascinating thing with Apigenin, is that while it has sleep and relaxation promoting effects, it also has some pronounced nootropic effects. One of the main pathways by which apigenin creates this effect, is by allosterically potentiating alpha 7 nicotinic acetylcholine receptors (α7 nAChR), which is a fascinating target for nootropic effects! In fact, we can go a step further and say that within the nootropic world, a safe, readily accessible and overall affordable α7 nAChR allosteric potentiator is a bit of a holy grail, and with that in mind, apigenin stands strong as a natural nootropic!
Now the effects of apigenin don’t just extend to our brains, in fact, apigenin has some wonderful effects on overall health! One very interesting effect that apigenin has, is that it blocks an enzyme called CD38. This enzyme breaks down NAD+, a very important compound for overall health. NAD+ production is actually one of the reasons why we supplement NMN too! By inhibiting CD38, NAD+ levels should be promoted and may stay elevated for much longer. This brings up an interesting stack idea too, supplementing apigenin and NMN together for enhancing NAD+ levels synergistically!
Studies have also shown that Apigenin helps to support the regulation of various bacteria in the gut microbiota. When Apigenin first enters the body, the first place it interacts with is the colon which makes it the focus of many studies of the digestive function benefits. A study found that while Apigenin does not promote the actual number of gut microbiota, it does help to promote the diversity of the gut microbiota to support digestive function! In addition to digestive function, Apigenin also supports cellular function, balanced oxidation levels and skin health! Another study even showed that Apigenin helps to mitigate oxidative stress caused by UV-B, which indicates that apigenin could be a fantastic compound for overall skin health. Clearly, this is not a supplement that you want to miss!
Sleep Stack: Apigenin + Magtein Magnesium L-Threonate Capsules + L-Theanine Capsules
A popular stack is combining apigenin, Magtein and L-Theanine together for sleep. We tried this stack out and liked it a lot, so give it a shot!*
Digestive Function Stack: Apigenin + EpiCor® Capsules
Both Apigenin and EpiCor® promote helpful bacteria in the gut to promote the overall function of the digestive system! That’s not all! This pair also promotes immune function!*
Balanced Oxidation Levels Stack: Apigenin + Reduced Glutathione Tablets
For balanced oxidation levels, the obvious addition to this stack is Reduced Glutathione! Apigenin and Reduced Glutathione work together to promote balanced oxidation levels while also supporting cognitive and cellular function!*
NAD+ Stack: Apigenin + Nicotinamide Mononucleotide Capsules
One of the main purposes of NMN supplementation is to enhance NAD+ levels in the body. Conveniently, apigenin helps slow down the breakdown of NAD+, by inhibiting an enzyme called CD38. When combining the NAD+ elevating effects of NMN with the NAD+ breakdown inhibition effects of apigenin, we can in theory produce a more pronounced effect on NAD+ levels than either in isolation! This is a big tip if you are interested in NAD+.*
As a dietary supplement, take one 200mg Apigenin capsule daily.
To gain more insight, see the Apigenin reviews and experiences below.
Nootropics Depot offers 30ct. or 120ct. jars of high quality Apigenin. Nootropics Depot’s Apigenin has been lab-tested and verified for both product purity and identity.
| *Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated by the FDA. |
Sleep (200mg) probably not a great idea, kept waking up after 2 hours sleep and unable to get back to sleep (wired). Read a Reddit page saying take it earlier during the day (morning 200mg) - absolutely amazing, clean energy (only the the 1st hour or so after are you drowsy and then does a 180 and gives you energy.
Although this product was recommended to my male partner I found when I use it, I get a good night sleep and feel less anxious during the day (I am a female)
Ok here goes. Apigenin 180x50mg For the first month this was awesome. Noticeable stress reduction, more effective than melatonin for sleep, just total chill. High quality as usual from ND. Different doses had different effects and not linearly; so 150mg had a different effect than both 200mg and 50mg for example. I used it daily... Then just after a month in to it I had severe anxiety rebound every day after taking it. I even gave it a week off and then had one 50mg and had an intense panic attack. I wasn't taking anything else at the time. Posting my experience on the subreddit just lead to being downvoted off the page... something I have noticed there, people won't allow you to say anything negative anymore, despite other threads (also downvoted) by people who had rebound anxiety issues also. I would recommend this but I would recommend keeping plenty of l-theanine around for the inevitable(?) rebound anxiety it causes over time. It messes around with GABA afterall. I had similar issues with baical skullcap, which also contains apigenin, see my review there under "xnxxnxxxxn". I want to try supplementing OptiNAD but notice that has apigenin too, being an expensive product I'm not sure if I should risk it.
This apigenin product certainly helps me fall and stay asleep. I believe I also achieve a deeper and better quality of sleep. I stack this with Magnesium L-Threonate, L-Theanine and occasionally I throw in Matrine if I've consumed caffeine too late in the day. I haven't isolated this variable but I can say with certainty that in combination with the others I mentioned above, I've seen amazing results and continue to.
I find the higher dose too much for sleep when taken at bedtime. It feels like high dose of melatonin to me. I will try to take it earlier and will order the small dose bottle.
Great for ending the day after work. A favorite in my evening stack.
This is great
A noticeable reduction in stress from taking this in the mornings. It works almost too well for me if taken in the mornings due to its calming effects. I am taking for cd38 reduction. No sides. Always love ND stuff
Love this - very calming & much easier than consuming 50 cups of chamomile tea, I imagine!
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