About Dihydromyricetin Capsules

Dihydromyricetin is a powerful flavonoid extracted from Ampelopsis grossedentata, standardized to support healthy alcohol metabolism by enhancing aldehyde dehydrogenase activity. Beyond its role in acetaldehyde clearance, this versatile compound promotes mood enhancement through BDNF elevation, supports GABA-A receptor density, and activates longevity pathways via SIRT1 and SIRT3 modulation.

Our Dihydromyricetin Story

We first encountered dihydromyricetin while developing our Alcohol Defense formula, where its exceptional ability to enhance aldehyde dehydrogenase activity made it the cornerstone ingredient. However, our focus on alcohol metabolism initially caused us to overlook the broader potential of this flavonoid. As we delved deeper into the research, we discovered dihydromyricetin's impressive range of benefits extending far beyond acetaldehyde clearance.

The breakthrough came when we realized that aldehyde exposure isn't limited to alcohol consumption. We encounter various aldehydes daily through diet, carbohydrate metabolism, vehicle exhaust, and indoor air pollution, with acetaldehyde levels up to 10 times higher indoors than outdoors. By enhancing ALDH2 enzyme function, dihydromyricetin offers comprehensive aldehyde management that supports daily wellness. Combined with its ability to increase gephyrin levels for GABA-A receptor density, elevate BDNF for cognitive support, and activate longevity pathways, we knew this versatile compound deserved its own standalone offering for both targeted and daily use.

Benefits

• Supports Alcohol Metabolism: Boosts aldehyde dehydrogenase activity to rapidly convert acetaldehyde into beneficial acetate, helping clear alcohol byproducts from your system more efficiently.
• Mood-Elevating Effects: Increases brain-derived neurotrophic factor (BDNF) levels and reduces neuroinflammation, creating rapid improvements in emotional well-being and mental outlook.
• Upregulates Gaba-A Receptor: Elevates gephyrin protein levels, which directly increases GABA-A receptor density for enhanced calming neurotransmitter function.
• Promotes Longevity: Activates SIRT1 and SIRT3 proteins, key regulators of cellular aging processes and metabolic health for enhanced lifespan benefits.

Dihydromyricetin also provides comprehensive aldehyde protection throughout daily life. We encounter aldehydes from vehicle exhaust, indoor air pollution, and normal carbohydrate metabolism. The enhanced ALDH2 enzyme activity supports cellular health even when alcohol isn't involved, making this flavonoid valuable for everyday wellness maintenance.

Quality and Standardization

• Purity Testing: We rigorously test our dihydromyricetin capsules for heavy metals, microbials, and contaminants to ensure each batch meets our strict safety standards before release.
• Standardized Extract Quality: Our dihydromyricetin is derived from high-quality Ampelopsis grossedentata vine extract, carefully processed to maintain the bioactive compounds responsible for aldehyde dehydrogenase enhancement.
• Third-Party Verification: Every batch undergoes independent laboratory analysis to verify identity and potency, with certificates of analysis available to confirm the 500mg dosage accuracy per capsule.
• Sourcing Standards: We source our dihydromyricetin from trusted suppliers who follow sustainable harvesting practices and maintain consistent quality control throughout the extraction process.
• Formulation Precision: Each capsule contains exactly 500mg of pure dihydromyricetin with no unnecessary fillers, artificial colors, or preservatives, ensuring maximum bioavailability and therapeutic potential.

Mechanism of Action

• Aldehyde Dehydrogenase Enhancement: Dihydromyricetin specifically increases the activity of ALDH2 enzyme, which rapidly converts acetaldehyde and other harmful aldehydes we encounter daily from environmental sources like car exhaust and indoor off-gassing into harmless acetate compounds.
• Gephyrin Protein Upregulation: This flavonoid elevates gephyrin levels, a scaffolding protein essential for assembling and maintaining GABA-A receptors at synapses, leading to increased receptor density and enhanced GABAergic signaling throughout the brain.
• SIRT1 and SIRT3 Activation: Dihydromyricetin functions as a potent activator of these key longevity enzymes, promoting cellular repair mechanisms, mitochondrial biogenesis, and metabolic efficiency at the cellular level.
• Neuroinflammatory Modulation: The compound dampens excessive neuroinflammatory responses while supporting the brain's natural inflammatory resolution pathways, creating an optimal environment for neuroplasticity and cognitive function.

Overview of the Science

Research demonstrates that dihydromyricetin exerts its effects through multiple mechanisms of action [1]. Studies show it significantly enhances the activity of aldehyde dehydrogenase enzymes, particularly ALDH2, which is responsible for converting acetaldehyde into acetate [2]. This enhanced enzymatic activity extends beyond alcohol metabolism, as aldehydes are prevalent environmental toxins found in car exhaust and indoor air from off-gassing materials. Additionally, dihydromyricetin modulates GABAergic neurotransmission by increasing gephyrin protein levels, which directly supports GABA_A receptor clustering and density at synaptic sites [3]. This mechanism contributes to its mood-elevating and anxiolytic properties.

The flavonoid also demonstrates significant effects on cellular health through SIRT1 and SIRT3 activation, promoting mitochondrial biogenesis and enhancing cellular stress resistance. Research indicates that dihydromyricetin can rapidly increase brain-derived neurotrophic factor (BDNF) expression while simultaneously reducing neuroinflammatory markers [4]. These dual effects support cognitive function and may contribute to its mood-enhancing properties. The compound's hepatoprotective effects appear to stem from its ability to enhance lipid metabolism and support healthy liver enzyme activity [5].

[1] Shen Y, Lindemeyer AK, Gonzalez C, Shao XM, Spigelman I, Olsen RW, Liang J. Dihydromyricetin as a novel anti-alcohol intoxication medication. J Neurosci. 2012;32(1):390-401.

[2] Silva J, Yu X, Moradian R, Folk C, Spatz MH, Kim P, Bhatti AA, Davies DL, Liang J. Dihydromyricetin Protects the Liver via Changes in Lipid Metabolism and Enhanced Ethanol Metabolism. Alcohol Clin Exp Res. 2020;44(5):1046-1060.

[3] Al Omran AJ, Shao AS, Watanabe S, Zhang Z, Zhang J, Xue C, Ye B, Shankavaram V, Lai M, Huang WH, Camandola S, Pletnikov M, Liang J, Maudsley S, Martin B. Modulation of Hippocampal GABAergic Neurotransmission and Gephyrin Levels by Dihydromyricetin Improves Anxiety. Front Neurosci. 2020;14:100.

[4] Al Omran AJ, Azam S, Kaur A, Ghareeb A, Veeramachaneni GK, Singh S, Broering DC, Nagarkatti M, Nagarkatti P. Dihydromyricetin Protects Against Ethanol-Induced Toxicity in SH-SY5Y Cell Line: Role of GABAA Receptor. Neurochem Res. 2022;47(6):1666-1679.

[5] Pan J, He S, Xu H, Zhan X, Yang X, Xiao H, Shi H, Ren J. Preparation of Dihydromyricetin-Loaded Self-Emulsifying Drug Delivery System and Its Anti-Alcoholism Effect. Pharmaceutics. 2023;15(9):2296.

Ingredients

Dihydromyricetin:

• Ampelopsis grossedentata extract
• 98% Dihydromyricetin purity
• 500mg per capsule

Our 98% standardized dihydromyricetin extract represents one of the highest purity levels available in the supplement market. This precise standardization ensures consistent potency and bioavailability across every batch, delivering the exact amount of active flavonoid compounds your body needs. The 98% purity standard eliminates unnecessary fillers and plant matter, concentrating the beneficial compounds that make dihydromyricetin effective for supporting liver support supplements and overall cellular health supplements protocols.