This is a fascinating amino acid with a really unique blend of effects. Phenylalanine can exist in two different forms, dextrorotatory phenylalanine also revered to as D-Phenylalanine and levorotatory phenylalanine, also known as L-Phenylalanine.
L-Phenylalanine is one of the amino acid precursors that we use to synthesize dopamine, so supplementing with some extra L-Phenylalanine will help increase overall dopamine levels which can have a positive effect on focus, mood, motivation and overall energy levels.
D-Phenylalanine on the other hand is not a dopamine precursor, yet it does inhibit the activity of an enzyme called enkephalinase. This enzyme breaks down endorphin type compounds, so blocking its activity with D-Phenylalanine will help increase endorphin levels. This could have a great effect on both mood and pain!
Our DL-Phenylalanine is an equal mixture of both D and L-Phenylalanine, and thus, you get a very nice and comprehensive blend of effects when supplementing with DL-Phenylalanine!
DL-Phenylalanine, or DLPA, is an essential amino acid and is a racemic form of Phenylalanine. Essential amino acids are a type of amino acid that the body can only get from outside sources, such as foods and supplements. DLPA is important for its function as a precursor to many beneficial compounds and neurotransmitters, such as tyrosine, dopamine and norepinephrine!
DL-Phenylalanine, due to its D-Phenylalanine content also has a very interesting trick up its sleeve, it can enhance endorphin levels! You are likely already aware of endorphins due to their association with the “runners high”, which likely is due to increased endorphin levels. By inhibiting enkephalinase (the enzyme that breaks down endorphins) DL-Phenylalanine is able to elevate overall endorphin levels.
Due to this unique enkephalinase effect, DL-Phenylalanine has a very unique mood elevating effect in addition to fairly robust pain management effects! It may even be a good thing to take on a run to further increase your “runners high”, as it would keep the exercise generated endorphins around a little longer!
In order to block enkephalinase and promote pain management, it is important to note that DLPA is an electrically neutral amino acid. This is significant because it means that DLPA is able to easily cross the blood-brain barrier and work directly within the brain. It is thought that the pain management effects of DLPA are because it blocks enkephalinase, an enzyme that breaks down endorphins. Endorphins have very beneficial pain regulating effects, and due to this DLPA is a fantastic option for pain management!
DPLA doesn’t stop there. It also promotes dopamine synthesis! Since dopamine is an important mediator of focus and motivation, it is no surprise the DLPA is a great supplement for motivation!
Pain Management: DL-Phenylalanine + Rephyll Capsules
Rephyll, a highly optimized formulation of Beta Caryophyllene, is found in black pepper, cloves, rosemary and more! Supplementation with Rephyll can help support pain management in addition to many other benefits. In combination with DL-Phenylalanine, this is the ultimate stack!
The Dopamine Stack: DL-Phenylalanine + OmegaTAU Capsules
OmegaTAU is well-loved for its ability to enhance dopaminergic sensitivity. When paired with DL-Phenylalanine, the two of these create a well-rounded dopamine support!
The Feel Good Stack: DL-Phenylalanine + Apigenin Capsules
As a flavone with fantastic mood effects, Apigenin is the perfect addition to DL-Phenylalanine. With support for sleep, relaxation and digestive function as well, this will make for a very well rounded stack!
As a dietary supplement, take one 500mg capsule of DL-Phenylalanine daily.
To gain more insight, see the DL-Phenylalanine reviews and experiences below.
Nootropics Depot offers 60ct. and 180ct. jars of high-quality DL-Phenylalanine. Nootropics Depot’s DL-Phenylalanine has been lab-tested and verified for both product purity and identity.
Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.