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EpiCor® Powder

Clinically studied whole food fermentate that supports immune function through gut health and natural killer cell activity.

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EpiCor® Powder

Clinically studied whole food fermentate that supports immune function through gut health and natural killer cell activity.

(5 Reviews) Write a Review

View All Reviews

Available in multiple forms! Click Here for:
  • Backed by 7 Human Clinical Trials
  • Proprietary Whole Food Yeast Fermentate
  • Supports 4 Lines of Immune Defense
  • FDA-Acknowledged New Dietary Ingredient

3rd Party Lab Tested & Verified

See Why ND EpiCor Is The Best

Updated On: 05/05/2026

$24.99 - $39.99

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ATTENTION: This product does not include a scoop. Learn more

Benefits

When You'll Notice Effects

2-3 Weeks

  • Immune Immune
  • Gut Health Gut Health
  • Inflammation Inflammation
  • Oxidation Oxidation

Why ND Epicor?

The ONLY yeast fermentate with seven human clinical trials
test

How To Take

Dose
Dose

500mg (Per Serving)

Timing
Timing

Flexible

How to Take
How to Take

With Or Without Food

Frequency
Frequency

1 Time Daily

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  • About EpiCor® Powder

    EpiCor® is a unique yeast fermentate derived from baker's yeast through a proprietary fermentation process that supports Immune system health. This whole food powder contains naturally occurring beta-glucans, vitamins, amino acids, and metabolites that work together to promote your body's natural immune defenses. EpiCor provides comprehensive immune support through multiple pathways, helping to maintain healthy immune function and Gut Health.

    Our EpiCor® Story

    The immune supplement market was flooded with single-ingredient extracts and synthetic compounds, yet lacked clinically-studied whole food options that could provide comprehensive immune system support. Most products focused on just one aspect of immunity, leaving gaps in coverage that could leave you vulnerable during times when you need optimal immune function most.

    Our search led us to EpiCor®, a breakthrough ingredient created by Embria Health Sciences through years of research and development. This patented yeast fermentate represents a different approach to immune support, providing a complex matrix of bioactive compounds that work together rather than relying on isolated nutrients. With seven human clinical trials backing its efficacy and FDA recognition as a New Dietary Ingredient, EpiCor® met our rigorous standards for both safety and scientific validation, making it the clear choice for customers seeking evidence-based immune support.

    Benefits

    • Supports Healthy Immune Balance: EpiCor promotes production of secretory immunoglobulin A (sIgA) in saliva, a key antibody in mucous membranes that provides your first line of defense, while activating natural killer (NK) cells within hours to support your body's immune response.
    • Supports Healthy Gut Microbiome: As a prebiotic, EpiCor feeds beneficial bacteria in the gut, helping maintain a balanced microbiome that's essential for overall Gut Health and immune function.
    • Supports Healthy Inflammatory Response: The naturally occurring beta-glucans and metabolites in this yeast fermentate help promote balanced inflammatory responses throughout the body.
    • Supports Antioxidant Defense: EpiCor helps promote balanced levels of oxidation, supporting your body's natural cellular protection mechanisms.

    EpiCor's immune support works through four distinct defense pathways simultaneously. This whole food yeast fermentate contains a complex matrix of vitamins, amino acids, and metabolites that support both immediate and adaptive immune responses, unlike single-ingredient immune supplements.

    Quality and Standardization

    • Proprietary Manufacturing Process: Our EpiCor® undergoes Embria Health Sciences' proprietary fermentation and drying process following cGMP manufacturing guidelines, creating a consistent whole food powder with preserved beta-glucans and metabolites that maintains its bioactive integrity from batch to batch.
    • FDA New Dietary Ingredient Status: EpiCor® has earned New Dietary Ingredient (NDI) status from the FDA and features multiple safety studies published in the Journal of Toxicology, demonstrating its comprehensive safety profile through rigorous scientific evaluation.
    • Clinical Research Foundation: We source EpiCor® backed by seven human clinical trials including five randomized, double-blind, placebo-controlled studies that meet the gold standard in scientific research, plus two published animal studies and two in vitro studies validating its immune support properties.
    • Third-Party Laboratory Testing: Each batch undergoes comprehensive testing at third-party labs to verify purity, potency, and absence of contaminants, ensuring you receive the exact 500mg dose of active EpiCor® yeast fermentate per serving.

    Mechanism of Action

    • Yeast Fermentation Process: EpiCor® is produced by depriving baker's yeast cells of oxygen, which triggers the production of bioactive compounds including beta-glucans, amino acids, and metabolites that support immune function.
    • Secretory IgA Production: The fermentate promotes secretory immunoglobulin A (sIgA) synthesis in saliva and mucous membranes, creating your body's first barrier against environmental challenges.
    • Natural Killer Cell Activation: Bioactive compounds in EpiCor® rapidly enhance natural killer (NK) cell activity within hours, supporting your body's cellular immune surveillance system.
    • Prebiotic Activity: As a whole food powder, EpiCor® functions as a prebiotic that selectively feeds beneficial gut bacteria, strengthening the gut-immune axis through microbiome modulation.
    • Antioxidant Support: The fermentation process preserves naturally occurring antioxidant compounds that help maintain balanced oxidative stress levels throughout the body's cellular systems.

    Overview of the Science

    EpiCor® represents a breakthrough in immune research through its comprehensive clinical validation [1]. The yeast fermentate has undergone seven human clinical trials, with five meeting the gold standard of randomized, double-blind, placebo-controlled methodology. Research demonstrates EpiCor's unique ability to support multiple immune pathways simultaneously, from activating natural killer cells within hours to promoting beneficial gut bacteria populations. Studies indicate that the fermentate's complex matrix of beta-glucans, amino acids, and metabolites work synergistically to support immune resilience more effectively than isolated compounds.

    The fermentation process creates a unique metabolic fingerprint that distinguishes EpiCor® from standard yeast extracts or synthetic immune compounds. When baker's yeast is deprived of oxygen, it produces specific bioactive metabolites including mannan oligosaccharides, peptides, and nucleotides that support cellular health. Animal studies demonstrate EpiCor's prebiotic effects on intestinal barrier integrity, particularly during stress conditions [1]. The whole food matrix preserves naturally occurring vitamins, minerals, and cofactors that enhance bioavailability and support the body's natural antioxidative stress response pathways.

    [1] Ducray HAG, Globa L, Pustovyy O, Reeves S, Andersen B, Vodyanoy V, Sorokulova I. Yeast fermentate prebiotic improves intestinal barrier integrity during heat stress by modulation of the gut microbiota in rats. J Appl Microbiol. 2019

    Ingredients

    EpiCor® Powder:

    • EpiCor® dried yeast fermentate (Saccharomyces cerevisiae)
    • 500mg per serving
    • Whole food fermentate powder

    This 500mg dosage represents the clinically validated amount used across multiple human trials, ensuring you receive the exact therapeutic dose that researchers have proven effective for immune support. The whole food fermentate designation means you're getting a complete matrix of bioactive compounds rather than isolated extracts, providing the synergistic benefits that make EpiCor® unique among nutritional supplements in the immune category.

  • Lab Testing Results / Certificate of Analysis (COA)

  • Frequently asked questions

    1. Can EpiCor cause brain fog like S. boulardii?

      EpiCor is unlikely to cause brain fog like S. boulardii can. Our EpiCor is a yeast fermentate, not live yeast, so it doesn't colonize the gut or produce metabolic byproducts that can trigger cognitive issues. The fermentation process creates beneficial compounds that support immune function without the potential for overgrowth that live probiotics cause.

    2. How much EpiCor powder should I take daily?

      The recommended daily dose is 500mg of EpiCor® powder taken once daily. Since this product does not include a measuring scoop, you'll need a milligram scale for accurate dosing - we carry one at nootropicsdepot.com/nootropics-depot-milligram-scale-nds-201/. EpiCor® can be taken with or without food and typically reaches peak effects within 2-3 weeks of consistent use.

    3. How does EpiCor work differently than probiotics?

      EpiCor works as a postbiotic rather than a probiotic, meaning it provides beneficial metabolites and compounds that are already fermented rather than live bacteria. While probiotics add beneficial bacteria to your gut, EpiCor supports your existing microbiome by feeding beneficial bacteria and providing immune-supporting compounds like beta-glucans that activate natural killer cells. This whole food fermentate works through multiple immune pathways simultaneously, offering broader immune support than typical single-strain probiotics.

    4. How long does EpiCor take to work?

      EpiCor® provides some immune support benefits within hours, particularly for natural killer cell activity. The full spectrum of immune benefits typically develops over 2-3 weeks of consistent daily use. Our EpiCor® powder supports both immediate immune responses and longer-term gut health improvements that contribute to overall immune function.

    5. Can I stack EpiCor with other gut health supplements?

      Yes, EpiCor® can be safely stacked with other gut health supplements like probiotics, prebiotics, and digestive enzymes. Our EpiCor® powder works synergistically with probiotics by supporting beneficial gut bacteria populations. Combining it with other targeted gut supplements provides more comprehensive digestive and immune benefits.

    6. Is EpiCor vs Functional Yeast Extract better for gut health?

      EpiCor® offers more comprehensive gut health benefits than functional yeast extracts through its unique whole food fermentate profile containing naturally occurring beta-glucans, amino acids, and metabolites that promote beneficial gut bacteria populations. Most functional yeast extracts focus primarily on isolated beta-glucans, while our EpiCor® has been studied in seven human clinical trials showing it supports both digestive health and immune function through multiple pathways.

    7. Why choose Nootropics Depot's EpiCor over other brands?

      Our EpiCor® powder is the genuine, clinically-studied ingredient with seven human trials backing its effectiveness. We provide third-party lab testing for purity and potency, ensuring you get exactly what's on the label. Unlike many brands that use inferior yeast extracts or diluted formulations, we offer pure EpiCor® at competitive pricing with our industry-leading quality standards.

    8. Does EpiCor help with nutrient absorption issues?

      EpiCor supports gut health by promoting beneficial bacteria populations, which can indirectly support healthy nutrient absorption. Our EpiCor powder contains naturally occurring beta-glucans and metabolites that help maintain a balanced gut microbiome, and a healthier gut environment typically supports better nutrient uptake and digestive function.

Trust Through Transparency

Your health matters, which is why we only use the best 3rd party ISO accredited labs and cGMP certified and FDA registered facilities right here in the USA

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