About IMMUSE Capsules

Immuse is a clinically researched paraprobiotic featuring Lactococcus Lactis Strain Plasma, a heat-killed lactic acid bacterium that uniquely activates plasmacytoid dendritic cells (pDCs). Unlike traditional probiotics, this shelf-stable ingredient requires no refrigeration while supporting immune function, digestive health, and exercise performance through its pDC activation mechanism.

Our IMMUSE Story

For decades, scientists believed no lactic acid bacterium could activate plasmacytoid dendritic cells, the master regulators of our immune system. This gap in immune support supplementation was significant, as pDCs coordinate the activity of multiple immune cell types rather than targeting just one pathway. Traditional immune supplements could only activate specific immune cells like natural killer cells, missing the broader orchestration that pDCs provide.

Researchers at Kirin spent years screening over 100 lactic acid bacteria with advanced technology to achieve what seemed impossible. They discovered that Lactococcus Lactis Strain Plasma could activate pDCs, earning the "plasma" designation for its ability to target PLASMAcytoid dendritic cells. We secured this breakthrough ingredient because it works through the immune system's command center rather than individual soldier cells.

Benefits

• Improves Immune Function: Immuse activates plasmacytoid dendritic cells (pDCs), the immune system's master regulators that produce interferon alpha to coordinate your body's entire immune response.
• Supports Digestive Function: The paraprobiotic provides the benefits of traditional probiotics without requiring refrigeration, helping maintain a healthy gut health environment through its stable, heat-killed bacterial fraction.
• Supports Metabolic Processes: By optimizing immune cell communication, Immuse helps your body efficiently allocate energy resources and maintain healthy metabolic function during times of physical and mental stress.
• Supports Exercise Performance: Clinical research shows Immuse reduces exercise-induced fatigue and supports faster recovery, helping you maintain training intensity and get more from your fitness routine.

Immuse's ability to activate pDCs creates a cascading effect throughout your body's defense network. Unlike conventional lactic acid bacteria that only activate specific immune cells like natural killer cells, this strain coordinates multiple immune pathways simultaneously, making it an ideal foundation for comprehensive wellness support whether you're managing a demanding work schedule or pursuing athletic goals.

Quality and Standardization

• Clinically Researched Strain: Our Immuse capsules contain the exact Lactococcus Lactis Strain Plasma studied in multiple published clinical trials, ensuring you receive the precise strain formulation that demonstrated immune-supporting benefits in research settings.
• Heat-Killed Paraprobiotic: Unlike live probiotics that require refrigeration and may lose viability during shipping or storage, we use the heat-inactivated form that maintains its biological activity while providing exceptional shelf stability at room temperature.
• Standardized 50mg Dosage: Each capsule delivers precisely 50mg of Lactococcus Lactis Strain Plasma, matching the clinically effective dose used in human studies that demonstrated significant improvements in immune markers and exercise recovery.
• Identity and Purity Testing: We verify each batch through comprehensive lab testing to confirm the specific bacterial strain identity and absence of contaminants, ensuring consistent potency and safety in every capsule we produce.

Mechanism of Action

• Plasmacytoid Dendritic Cell Activation: Immuse contains isolated cellular fractions that specifically bind to toll-like receptors on plasmacytoid dendritic cells, triggering the production of interferon alpha and other signaling molecules that orchestrate immune cell communication throughout the body.
• Interferon Alpha Signaling: Once activated, pDCs release interferon alpha, which acts as a molecular messenger to enhance the activity of natural killer cells, T-cells, and B-cells, creating a coordinated cellular health response that supports overall immune vigilance.
• Heat-Stable Bioactive Components: The heat-killing process preserves specific cellular wall components and metabolites that retain immunomodulatory activity, allowing these paraprobiotic fractions to maintain their biological effects without requiring live bacterial cultures or refrigeration.
• Respiratory Epithelial Support: The interferon alpha cascade initiated by Immuse enhances the protective barrier function of respiratory tract epithelial cells, supporting the body's first line of defense against environmental challenges while promoting healthy respiratory function.

Overview of the Science

A meta-analysis of individual participant data from multiple clinical trials has demonstrated that Lactococcus lactis strain Plasma significantly reduces common cold-like symptoms and supports respiratory health in healthy adults [1]. Research specifically examining plasmacytoid dendritic cell activation shows that this strain's unique spherical structure allows it to interact with toll-like receptor 9, triggering robust immunomodulatory responses that conventional probiotics cannot achieve [2]. Clinical studies in athletes have revealed additional benefits beyond immune support, with participants experiencing reduced fatigue and improved performance markers during consecutive high-intensity exercise sessions [3].

Further research has validated Immuse's efficacy across diverse populations, including a randomized controlled trial in Vietnamese schoolchildren that documented reduced infectious disease incidence following regular supplementation [6]. The mechanistic studies reveal that this paraprobiotic's effects extend beyond direct pDC activation, facilitating crosstalk between plasmacytoid and myeloid dendritic cells through TLR9-dependent pathways [5]. Animal studies have confirmed the protective effects against viral infections, with cellular health supplements like Immuse demonstrating measurable immune enhancement in controlled settings [7].

[1] Kato Y, Kobayashi K, Kuramochi Y, Miyata T, Ushida Y, Hayamizu K. Frontiers in Immunology. 2025;16:1696989.

[2] Sugimura T, Jounai K, Ohshio K, Tanaka T, Suwa M, Fujiwara D. Clinical Immunology. 2013;149(3):509-518.

[3] Komano Y, Shimada K, Naito H, Fukao K, Ishihara Y, Fujii T, Kokubo T, Daida H. Journal of the International Society of Sports Nutrition. 2018;15:39.

[5] Jounai K, Ikado K, Sugimura T, Ano Y, Braun J, Fujiwara D. PLoS One. 2012;7(4):e32588.

[6] Iwatani S, Zago M, Sim K, Lau G, Eiamkulbutr S, Chuah L, Awang-Hazmi A, Shoji H, Shimizu T, Rajadurai V. Nutrients. 2022;14(3):552.

[7] Jounai K, Sugimura T, Ohshio K, Fujiwara D. International Immunopharmacology. 2018;56:321-327.

Ingredients

Lactococcus Lactis Strain Plasma:

• Heat-killed lactic acid bacterium (LC-Plasma)
• 50mg per capsule
• Paraprobiotic classification

This 50mg dosage represents the clinically validated amount used in published research studies. As a paraprobiotic, Immuse delivers consistent bioactive compounds without the variability concerns of live bacterial cultures, making it ideal for those seeking reliable nutritional supplements that support both immune function and digestive enzyme supplements protocols.