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KSM-66 Powder | Ashwagandha Root

Full-spectrum ashwagandha root extract standardized to support healthy stress response, mood balance, cognitive function, and muscle strength.

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KSM-66 Powder | Ashwagandha Root

Full-spectrum ashwagandha root extract standardized to support healthy stress response, mood balance, cognitive function, and muscle strength.

(57 Reviews) Write a Review

View All Reviews

Available in multiple forms! Click Here for:
  • Clinically Validated KSM-66 Extract
  • Full-Spectrum Root Standardization
  • Supports Stress and Muscle Recovery
  • Third-Party Lab Tested Purity

3rd Party Lab Tested & Verified

See Why ND KSM-66 Is The Best

Updated On: 05/23/2026

$16.99 - $24.99
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ATTENTION: This product does not include a scoop. Learn more

Benefits

When You'll Notice Effects

1-2 Weeks (With Immediate Effects)

KSM-66 Ashwagandha Root: A potent adaptogen supporting a balanced stress response, healthy mood, cognitive function, and muscle strength. This versatile supplement offers comprehensive benefits for overall well-being and physical performance.

  • Stress
  • Mood
  • Cognition
  • Muscle Mass

Why ND Ksm-66 Ashwagandha?

A full-spectrum Ashwagandha with complete bioactive preservation
test

How To Take

Dose
Dose

300mg (Per Serving)

Timing
Timing

Flexible

How to Take
How to Take

With Or Without Food

Frequency
Frequency

1-2 Times Daily

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  • About KSM-66 Ashwagandha Powder

    KSM-66 Ashwagandha full-spectrum extract branding over ashwagandha plant leaves.

    KSM-66 Ashwagandha Root Extract is a full-spectrum adaptogen sourced from Withania somnifera that preserves the natural balance of active compounds found in ashwagandha root. Standardized to 5% withanolides, this extract supports your body's ability to adapt to everyday stressors while promoting a sense of calm and balance. Whether you're seeking steady energy, mental clarity, or simply a more centered feeling throughout your day, KSM-66 offers comprehensive support for both mind and body.

    Our KSM-66 Story

    We first explored ashwagandha extracts and noticed a frustrating gap in the market. Most products used aggressive extraction methods that stripped away important compounds or relied on arbitrary standardization levels that didn't reflect the natural composition of the root. There had to be a better way to deliver ashwagandha's full benefits while maintaining the integrity that traditional use has relied on for centuries.

    We discovered KSM-66, an extract developed through 14 years of research using "Green Chemistry" methods that avoid harsh solvents. Their commitment to preserving the complete spectrum of active compounds, including withanolides, alkaloids, and saponins, in their natural ratios impressed us most. The 5% withanolide standardization isn't arbitrary; it replicates the exact balance found in traditional ashwagandha root, ensuring you receive the same adaptogenic benefits that have been validated in over 40 clinical studies. This attention to authenticity and scientific rigor made KSM-66 the clear choice for our customers who demand both tradition and innovation in their supplements.

    Benefits

    • Supports Healthy Stress Response: This adaptogen helps your body adapt to everyday stressors, promoting a sense of relaxation and resilience that helps you feel more balanced when life gets hectic.
    • Supports Positive Mood: Many users notice an improved sense of well-being with a calmer mood and more balanced energy throughout the day.
    • Supports Cognitive Health: KSM-66 supports cognitive function, helping you stay focused and clear-headed even during busy or demanding times.
    • Supports Muscle Health: For physically active individuals, the extract contributes to muscle strength, endurance, and faster recovery, making it popular among fitness enthusiasts.

    Research points to ashwagandha's ability to support a healthy inflammatory response, supporting your body's natural defenses and promoting overall vitality. The full-spectrum extract preserves the natural balance of active compounds from the root, ensuring you receive the complete benefits that make KSM-66 a reliable addition to your wellness routine.

    KSM-66 Ashwagandha study results chart showing 27.9% cortisol reduction, highlighting relaxation benefits over placebo.

    Quality and Standardization

    • Withanolide Standardization: Every batch is standardized to contain exactly 5% withanolides, replicating the natural balance of actives in ashwagandha root and delivering the calming and adaptogenic benefits validated in clinical research.
    • Green Chemistry Extraction: Our 14-year developed extraction process uses "Green Chemistry" methods that avoid harsh solvents and preserve the full spectrum of active compounds, including withanolides, alkaloids, and saponins.
    • Premium Quality Certifications: KSM-66 holds more than 40 quality certifications, including Non-GMO Project Verified, USDA Organic, Gluten-Free, and GMP-certified manufacturing standards.
    • Sustainable Sourcing & Testing: The roots are grown on dedicated farms in India using sustainable practices, and each batch undergoes rigorous testing for purity and potency with full transparency through our Certificates of Analysis.
    • Full-Spectrum Potency: We preserve the complete benefits the root has to offer through our full-spectrum extraction, ensuring you receive consistent and potent nootropics that maintain the natural integrity of the ashwagandha plant.

    Woman practicing yoga on a rock by the ocean with text promoting KSM-66 Ashwagandha for clear focus and calm mind.

    Mechanism of Action

    • Withanolide-Rich Bioactive Profile: KSM-66's unique blend of withanolides, alkaloids, and saponins works together to support the body's natural stress response systems, promoting healthy adaptation to daily challenges.
    • Cortisol Balance Support: The extract helps maintain healthy cortisol levels within the normal range, the body's primary stress hormone, promoting a natural sense of calm and resilience throughout the day.
    • Neurotransmitter System Support: KSM-66 supports GABA and serotonin pathways involved in mood regulation and cognitive function, promoting both calming and focus-enhancing effects.
    • Muscle Health Pathway Support: The extract influences cellular pathways involved in strength, recovery, and endurance, supporting physical performance through multiple mechanisms.
    • Cellular Protection Support: KSM-66 provides antioxidant support to help protect cells from everyday oxidative stress while supporting a healthy inflammatory response throughout the body.

    Nootropics Depot KSM-66 Ashwagandha 300mg capsules and bottles with benefits for stress relief, muscle recovery, and mental clarity.

    Overview of the Science

    The science behind KSM-66 Ashwagandha is both broad and promising. Multiple clinical studies have shown that regular supplementation supports a healthy stress response [1][2], promotes balanced cortisol levels, and supports a positive mood. Research also suggests benefits for cognitive health, with improvements in memory [3][4], attention, and executive function in healthy adults experiencing everyday stress.

    When it comes to supporting a healthy inflammatory response, research suggests ashwagandha supports the body's natural inflammatory balance by promoting healthy cytokine activity and enhancing antioxidant defenses. For those interested in fitness, studies have found that KSM-66 supports muscle strength, size, and recovery [5], especially when paired with resistance training. While more research is always helpful, the current evidence paints a compelling picture of KSM-66 Ashwagandha as a supplement that supports overall wellness [6], helping you feel your best both mentally and physically.

    [1] Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and [...] in adults. Indian J Psychol Med. 2012;34(3):255-262.

    [2] Choudhary D, Bhattacharyya S, Joshi K. Body weight management in adults under chronic stress through treatment with Ashwagandha root extract: a double-blind, randomized, placebo-controlled trial. J Evid Based Complementary Altern Med. 2017;22(1):96-106.

    [3] Remenapp A, Coyle K, Orange T, et al. Efficacy of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine. 2022;2022:8254344.

    [4] Choudhary B, Shetty A, Langade DG. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving memory and cognitive functions. J Diet Suppl. 2017;14(6):599-612.

    [5] Wankhede S, Langade D, Joshi K, et al. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial. J Int Soc Sports Nutr. 2015;12:43.

    [6] Verma N, Gupta SK, Tiwari S, Mishra AK. Safety of Ashwagandha Root Extract: A Randomized, Placebo-Controlled, study in Healthy Volunteers. Complement Ther Med. 2021;57:102642.

    Ingredients

    KSM-66® Ashwagandha Root Extract:

    • Withania somnifera (root)
    • 300mg per serving
    • Full-spectrum root extract

    KSM-66® represents the gold standard in ashwagandha supplementation, utilizing a proprietary extraction process that concentrates the root's naturally occurring withanolides while maintaining the herb's full spectrum of bioactive compounds. This patented extract undergoes rigorous testing to ensure consistent potency and purity, making it the most clinically studied ashwagandha extract available. The root-only extraction method preserves the traditional preparation that has been used for centuries in Ayurvedic practice, delivering the complete profile of beneficial compounds that make ashwagandha such a versatile adaptogen.

  • Lab Testing Results / Certificate of Analysis (COA)

  • Frequently asked questions

    1. Can I stack KSM-66 with other Nootropics Depot adaptogens?

      Yes, KSM-66 stacks well with other adaptogens like Rhodiola, Lion's Mane, and Cordyceps for comprehensive stress support and cognitive benefits. We recommend starting with individual products to assess your response before combining, and spacing doses throughout the day when stacking multiple adaptogens.

    2. Why choose Nootropics Depot's KSM-66 over other ashwagandha extracts?

      Our KSM-66 is a full-spectrum root extract standardized to 5% withanolides with the most human research backing its effectiveness for stress support and cognitive function. Unlike other extracts that focus on isolated components, KSM-66 preserves the natural balance of compounds found in ashwagandha. Every batch undergoes rigorous third-party testing for purity and potency.

    3. Should I cycle Nootropics Depot KSM-66 or take it continuously?

      KSM-66 can be taken continuously without cycling. Most clinical studies showing KSM-66's benefits used continuous daily supplementation, demonstrating that regular use is both safe and effective for optimal stress support and mood balance.

    4. Can I take 600mg daily of this KSM-66 powder safely?

      Yes, 600mg daily of our KSM-66 powder is within the safe and well-studied dosage range used in clinical research. Since this is a powder without an included scoop, you'll need a milligram scale for accurate measurement, we offer one at nootropicsdepot.com/nootropics-depot-milligram-scale-nds-201/.

    5. What does Ashwagandha do?

      KSM-66 Ashwagandha is a full-spectrum adaptogen that supports your body's ability to manage everyday stress while promoting calm and balance. Research shows it helps reduce perceived stress, lower cortisol levels, and support cognitive function including memory and attention. Our KSM-66 extract also supports mood balance, steady energy levels, and muscle strength.

    6. Is Ashwagandha safe?

      Yes, our KSM-66 Ashwagandha is generally safe for most healthy adults when taken as directed. Clinical studies show KSM-66 is well-tolerated with minimal side effects. Pregnant or nursing women, people with autoimmune conditions, or those taking medications should consult their healthcare provider before use.

    7. Does Ashwagandha make you sleepy?

      KSM-66 Ashwagandha doesn't typically cause drowsiness during the day, but supports better sleep quality when taken in the evening. This adaptogenic herb helps regulate your stress response and cortisol levels, leading to more restful sleep without sedating effects. Many people find it energizing when taken in the morning and calming when taken before bed.

    8. How long does Ashwagandha take to work?

      KSM-66 Ashwagandha can produce immediate effects within hours, but full benefits typically develop over 1-2 weeks of consistent use. Many people notice improved stress response and mood balance within the first few days, while cognitive function and physical performance benefits build gradually with regular supplementation.

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KSM-66 Powder | Ashwagandha Root

KSM-66 Powder | Ashwagandha Root

$16.99 - $24.99