About L-Citrulline DL-Malate 2:1 Powder

L-Citrulline DL-Malate 2:1 combines the amino acid L-citrulline with malic acid in a 2:1 ratio, creating a more stable and bioavailable form than citrulline alone. Your body converts citrulline into arginine, which then produces nitric oxide to support healthy cardiovascular function and blood flow.

Our L-Citrulline DL-Malate Story

We first explored citrulline supplementation and noticed most brands offered pure L-citrulline or citrulline malate with inconsistent ratios and questionable stability. Research showed that while pure citrulline works, the malate-bound form offered superior bioavailability and longer-lasting effects in the body. The challenge was finding a reliable source that maintained the proven 2:1 ratio used in clinical studies.

We developed our L-Citrulline DL-Malate to address these gaps. Our 2:1 formulation mirrors the exact ratio shown to increase plasma arginine levels more efficiently than direct arginine supplementation, requiring only 3 grams to achieve what 6 grams of arginine produces. Each batch undergoes rigorous testing through our third-party labs to verify both the citrulline content and the precise malate ratio, ensuring you get the consistent potency that supports healthy nitric oxide production and exercise performance.

Benefits

• Supports Muscular Endurance Performance: L-citrulline malate reduces exercise fatigue and sustains muscle performance by enhancing nitric oxide production and improving oxygen delivery to working muscles.
• Supports Healthy Blood Flow: As a vasodilator precursor, citrulline converts to arginine and then nitric oxide, promoting healthy circulation and optimal blood vessel function throughout the body.
• Supports Cardiovascular Health: Citrulline and malate work together to support heart health by promoting healthy blood pressure already within normal range and efficient cardiovascular function.
• Supports Exercise Recovery: Studies show citrulline malate reduces muscle soreness and supports faster recovery between training sessions by supporting healthy ammonia clearance and metabolism during exercise.

Research shows L-citrulline outperforms direct arginine supplementation for boosting plasma arginine levels. A German study found that just 3 grams of citrulline produced the same benefits as 6 grams of arginine. The 2:1 ratio with malate provides enhanced stability and bioavailability, making this an efficient choice for fitness enthusiasts and anyone seeking cardiovascular support.

Quality and Standardization

• 2:1 Ratio Standardization: Our L-Citrulline DL-Malate maintains a precise 2:1 ratio of citrulline to malate, verified through HPLC analysis to ensure consistent potency and enhanced stability compared to pure citrulline alone.
• Purity Verification: Each batch undergoes comprehensive testing for both product purity and identity through third-party labs, confirming the absence of contaminants and accurate ingredient composition.
• Malic Acid Enhancement: The DL-malate component provides superior bioavailability and gastric tolerance compared to standard citrulline, while supporting the Krebs cycle for enhanced energy metabolism at the cellular level.
• Pharmaceutical Grade Manufacturing: Manufactured in FDA-registered, cGMP-certified facilities to pharmaceutical standards, ensuring consistent quality and regulatory compliance for every batch produced.

Mechanism of Action

• Nitric Oxide Pathway: L-citrulline bypasses first-pass liver metabolism and converts directly to arginine in the kidneys, creating a more efficient route for blood flow supplements than direct arginine supplementation.
• Malate Enhancement: The DL-malate component participates in the citric acid cycle, supporting cellular energy production while stabilizing citrulline for improved absorption and reduced degradation in the digestive system.
• Sustained Arginine Release: Unlike direct arginine supplementation which peaks rapidly and declines, citrulline provides steady plasma arginine elevation over several hours, maintaining consistent nitric oxide availability.
• Ammonia Buffering: L-citrulline helps remove excess ammonia from muscle tissue during exercise through the urea cycle, reducing metabolic stress that contributes to supplements for muscle growth and performance decline.

Overview of the Science

Clinical research demonstrates that L-citrulline DL-malate offers significant advantages in vascular function and exercise performance. Studies have shown that citrulline malate supplementation supports healthy vasodilation through enhanced nitric oxide production [1]. The compound's role in the urea cycle is well-established, where citrulline helps maintain healthy ammonia clearance pathways [2][3]. Research comparing citrulline to direct arginine supplementation reveals that oral L-citrulline produces more efficient increases in plasma arginine levels, with studies showing that 3 grams of citrulline can match the bioavailability of 6 grams of arginine [4][5][6].

The malate component contributes to the supplement's effectiveness through its participation in cellular energy production. Malic acid serves as an intermediate in the citric acid cycle, supporting ATP synthesis and metabolism at the cellular level. Research in animal models has demonstrated that citrulline supplementation supports exercise performance and reduces fatigue markers [7]. The 2:1 ratio of citrulline to malate provides enhanced stability and bioavailability compared to pure citrulline, while the malate fraction supports the body's natural energy production pathways that complement fitness and performance goals.

[1] Rho S, Kang M, Choi B, et al. Nutrients. 2020;12(2):590.

[2] Imbard A, Bouchereau J, Arnoux JB, et al. Journal of Inherited Metabolic Disease. 2023;46(4):769-778.

[3] Tanaka N, Kido J, Nakamura K, et al. Pediatrics International. 2017;59(4):465-470.

[4] Schwedhelm E, Maas R, Freese R, et al. British Journal of Clinical Pharmacology. 2008;65(1):51-59.

[5] Suzuki T, Morita M, Hayashi T, Kamimura A. Bioscience, Biotechnology, and Biochemistry. 2017;81(2):372-375.

[6] Marini JC, Agarwal U, Didelija IC, et al. Journal of Nutrition. 2017;147(4):550-558.

[7] Takeda K, Machida M, Kohara A, et al. Journal of Nutritional Science and Vitaminology. 2011;57(3):246-250.

Ingredients

L-Citrulline DL-Malate 2:1 Powder:

• L-Citrulline DL-Malate (2:1 ratio)
• 3000mg per serving
• Pharmaceutical grade purity

The 3000mg serving size represents the clinically effective dosage established in research, providing optimal bioavailability without requiring the higher doses needed with straight arginine supplementation. Our pharmaceutical-grade sourcing ensures consistent particle size and dissolution rates, maximizing absorption efficiency for supplements for muscle growth and cardiovascular support applications.