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Lion's Mane Mushroom 1:1 Capsules

Pure fruiting body extract standardized to 25% beta-glucans for cognitive function, memory support, and nerve health.

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Lion's Mane Mushroom 1:1 Capsules

Pure fruiting body extract standardized to 25% beta-glucans for cognitive function, memory support, and nerve health.

(30 Reviews) Write a Review

View All Reviews

Available in multiple forms! Click Here for:
  • Pure Fruiting Body Only Extract
  • Standardized To 25% Beta-Glucans
  • Promotes Nerve Growth And Regeneration
  • Third-Party Lab Tested Purity

3rd Party Lab Tested & Verified

See Why ND Lion's Mane Is The Best

Evidence-Based, Fact-Checked

Updated On: 05/05/2026

$19.99

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Benefits

When You'll Notice Effects

3-4 Weeks (With Immediate Effects)

Lion's Mane Mushroom 1:1 Extract is a popular natural nootropic that may boost cognitive function, support memory, promote nerve health, and provide neuroprotection by promoting nerve regeneration, reducing inflammation, and oxidative stress.

  • Cognition Cognition
  • Immune Immune
  • Neuroprotection Neuroprotection
  • Memory Memory

WHY ND LION'S MANE?

The ONLY Lion's Mane made from pure fruiting body extract, not mycelium
test

How To Take

Dose
Dose

500mg (One Capsule)

Timing
Timing

Flexible

How to Take
How to Take

With Or Without Food

Frequency
Frequency

1-2 Times Daily

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  • About Lion's Mane Mushroom 1:1 Capsules

    You are looking at the original whole fruiting body Lion's Mane Mushroom in a convenient 1:1 capsule format. This certified organic extract delivers the full spectrum of naturally occurring compounds found in the Hericium erinaceus fruiting body, standardized to 25% beta-glucans. Unlike mycelium-on-grain products that dilute potency with substrate fillers, this pure fruiting body extract supports cognitive function, promotes healthy immune response, and helps maintain cardiovascular wellness.

    Our Lion's Mane 1:1 Story

    We observed a troubling trend in the mushroom supplement world: companies taking shortcuts with mycelium-on-grain products marketed as "mushrooms" when they aren't actually mushrooms at all. These products contain significant amounts of grain substrate rather than pure mushroom material, diluting the beneficial compounds that make Lion's Mane so valuable. Consumers deserved better than these convenient but inferior alternatives.

    Our approach was straightforward: source only certified organic fruiting bodies and preserve the natural compound ratios through careful 1:1 extraction. This method maintains the full spectrum of terpenoids, beta-glucans, and other bioactive compounds exactly as they occur in nature. The result is a Lion's Mane supplement that delivers authentic mushroom benefits without the compromise of grain fillers or artificial concentration ratios that can disrupt the natural synergy of compounds.

    Benefits

    • Promotes Cognitive Health: Lion's mane contains unique compounds like hericenones and erinacines that support healthy brain function and memory formation through natural neuroplasticity mechanisms.
    • Supports Immune System Function: The high concentration of 25% beta-glucans in this fruiting body extract supports robust immune defense and helps maintain healthy immune system responses.
    • Provides Neuroprotective Benefits: The polysaccharides and terpenoids work together to support healthy nerve cell maintenance and protect against normal oxidative stress in neural tissues.
    • Supports Memory: Regular supplementation supports healthy cognitive processing and information retention through the mushroom's natural neurotransmitter supporting properties.

    Beyond cognitive support, this whole fruiting body extract provides cardiovascular benefits through its beta-glucan content, which supports healthy cholesterol levels already within the normal range and promotes overall heart health.

    Quality and Standardization

    • Fruiting Body Verification: Our Lion's Mane 1:1 extract is produced exclusively from certified organic Hericium erinaceus fruiting bodies, ensuring you receive authentic mushroom material rather than mycelium-on-grain substitutes that contain significant filler content.
    • Beta-Glucan Standardization: Each capsule delivers a minimum of 25% beta-glucans verified through rigorous analytical testing, providing consistent levels of these immune-supporting polysaccharides that are naturally concentrated in high-quality fruiting bodies.
    • Compound Preservation: Our 1:1 extraction process maintains the natural balance of hericenones, erinacines, and other medicinal mushrooms bioactive compounds as they occur in the whole fruiting body without concentration or isolation.
    • Purity Testing: Every batch undergoes comprehensive laboratory analysis for identity verification, heavy metals, microbials, and contaminants to ensure the highest safety and quality standards for our mushrooms for mental clarity products.

    Mechanism of Action

    • Nerve Growth Factor (NGF) Stimulation: The hericenones found in Lion's Mane fruiting bodies cross the blood-brain barrier and stimulate the production of nerve growth factor, a protein essential for the growth, maintenance, and survival of neurons.
    • Beta-Glucan Immune Modulation: The 25% beta-glucan content activates immune cells like macrophages and natural killer cells through specific receptor binding, enhancing the body's natural defense mechanisms without overstimulating the immune response.
    • Myelin Sheath Support: Lion's Mane compounds promote the synthesis of myelin, the protective coating around nerve fibers that facilitates faster and more efficient nerve signal transmission throughout the nervous system.
    • Cardiovascular Protection: The polysaccharides and triterpenes in the fruiting body support healthy cholesterol metabolism and promote optimal blood circulation by helping maintain the integrity of blood vessel walls.
    • Antioxidant Defense: Natural phenolic compounds and ergothioneine in Lion's Mane provide anti oxidative stress protection by neutralizing free radicals that can damage cellular structures, particularly in neural tissue where oxidative stress is a key factor in cognitive decline.

    Overview of the Science

    Lion's Mane mushroom demonstrates significant cognitive enhancement properties across multiple clinical trials. Research shows that Lion's Mane supplementation improves cognitive function, stress levels, and mood in young adults [1]. In a landmark double-blind placebo-controlled study, participants with mild cognitive impairment experienced substantial improvements after taking Hericium erinaceus for 16 weeks [2]. Additional research confirms that oral intake of Lion's Mane enhances various cognitive functions, particularly memory formation and recall [3]. These cognitive benefits appear to be linked to the mushroom's ability to stimulate nerve growth factor production and support neuroplasticity mechanisms in the brain.

    Beyond cognitive enhancement, Lion's Mane demonstrates notable effects on mood regulation and cardiovascular health. Clinical trials reveal that four weeks of Hericium erinaceus supplementation significantly reduces depression and anxiety symptoms [4]. The cardiovascular benefits stem from Lion's Mane's ability to inhibit LDL cholesterol oxidation and reduce HMG-CoA reductase activity, supporting healthy cholesterol levels already within the normal range [5]. The immunomodulatory effects of Lion's Mane polysaccharides are mediated through intestinal immune pathways, demonstrating how this mushroom supports overall immune system function through gut health mechanisms [6].

    [1] Docherty S et al. Nutrients. 2023;15(22):4842.

    [2] Mori K et al. Phytother Res. 2009;23(3):367-372.

    [3] Saitsu Y et al. Biomed Res. 2019;40(4):125-131.

    [4] Nagano M et al. Biomed Res. 2010;31(4):231-237.

    [5] Rahman MA et al. Biomed Res Int. 2014;2014:828503.

    [6] Sheng X et al. Food Funct. 2017;8(3):1020-1027.


    Click here to read the Research Snapshot

    Ingredients

    Lion's Mane Extract:

    • Hericium erinaceus (fruiting body)
    • 500mg per capsule
    • 1:1 extract ratio

    Our Lion's Mane uses a 1:1 extract ratio, meaning one gram of raw mushroom produces one gram of extract. This gentle concentration preserves the full spectrum of bioactive compounds naturally found in Lion's Mane fruiting bodies, including hericenones and erinacines. Unlike heavily concentrated extracts that may lose delicate compounds during processing, this approach maintains the mushroom's original nutritional profile while providing a consistent, standardized dose.

The Science

What Our Scientific Board Does

The Process

What Do They Do?

  • Review Product Claims
  • Review Cited Research
  • Suggest Changes to Claims
  • Approves Final Conclusions
See The Process

Overview Of The Scientific Evidence

Our Research Snapshot

What Does The Research Show?

Early research suggests Lion’s Mane Mushroom 1:1 Extract may improve memory, support brain cell growth, and promote cognitive function and nerve health.

Understand The Evidence

Trust Through Transparency

Your health matters, which is why we only use the best 3rd party ISO accredited labs and cGMP certified and FDA registered facilities right here in the USA

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Lion's Mane Mushroom 1:1 Capsules

Lion's Mane Mushroom 1:1 Capsules

$19.99