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N-Acetyl L-Cysteine Powder | NAC

High-purity amino acid powder that supports immune function, supports a healthy oxidative stress response, and provides antioxidant support.

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N-Acetyl L-Cysteine Powder | NAC

High-purity amino acid powder that supports immune function, supports a healthy oxidative stress response, and provides antioxidant support.

(14 Reviews) Write a Review

View All Reviews

Available in multiple forms! Click Here for:
  • Pharmaceutical Grade Purity Verified
  • Powerful Antioxidant and Detox Support
  • Third-Party Lab Tested Quality
  • Immediate Acting Immune Support

3rd Party Lab Tested & Verified

See Why ND NAC Is The Best

Updated On: 05/23/2026

$27.99 - $45.99

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Benefits

When You'll Notice Effects

Immediate Effects

N-Acetyl L-Cysteine (NAC) provides antioxidant support that supports immune function, supports a healthy oxidative stress response, and supports a healthy inflammatory response. It also supports healthy neurological function.

  • Immune
  • Oxidation
  • Inflammation
  • Neuroprotection

Why ND N-acetyl L-cysteine?

The highest purity NAC powder we tested with comprehensive third-party testing
test

How To Take

Dose
Dose

500mg (Per Serving)

Timing
Timing

Flexible

How to Take
How to Take

Empty Stomach

Frequency
Frequency

1 Time Daily

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  • About N-Acetyl L-Cysteine Powder

    N-Acetyl L-Cysteine (NAC) is a stable, bioavailable form of the semi-essential amino acid L-cysteine that supports immune function and cellular protection. This antioxidant precursor helps replenish glutathione levels, your body's master antioxidant, while supporting a healthy inflammatory response and respiratory function.

    Our NAC Story

    Researching NAC supplements revealed a concerning pattern: many products suffer from questionable purity and potency. NAC degrades when exposed to moisture and heat, compromising its effectiveness. Many manufacturers overlook proper storage and handling protocols, resulting in products that may not deliver the intended benefits.

    We sourced pharmaceutical-grade N-Acetyl L-Cysteine and implemented strict quality control measures throughout our supply chain. Our NAC undergoes comprehensive testing for purity, potency, and heavy metals at our third-party labs to ensure you receive a consistently potent product. The result is a clean, effective NAC powder that maintains its integrity from manufacturing to your doorstep.

    Benefits

    • Supports Immune Function: NAC supports glutathione production, a critical antioxidant that supports white blood cell activity and helps your body maintain healthy immune responses.
    • Supports Cellular Protection: NAC supports protection against free radicals while replenishing your body's natural antioxidant reserves, protecting cells from oxidative stress caused by pollution, exercise, and normal metabolic processes.
    • Supports Healthy Inflammatory Response: NAC supports balanced cytokine production and helps maintain your body's natural inflammatory response.
    • Supports Neurological Function: NAC crosses the blood-brain barrier to support neuronal health, protecting brain cells and supporting cognitive function through enhanced cellular health.

    NAC also supports respiratory health by helping thin mucus secretions in the lungs and airways, making it easier to clear congestion and maintain healthy breathing patterns. Research suggests it supports liver detoxification processes by helping the organ process and eliminate toxins more efficiently.

    Quality and Standardization

    • High Purity Standards: Our N-Acetyl L-Cysteine powder undergoes rigorous testing for both identity and purity verification, ensuring you receive a premium amino acid supplement free from contaminants and adulterants.
    • Third-Party Laboratory Testing: Every batch is analyzed by independent, ISO-accredited laboratories to confirm potency, purity, and safety before reaching our customers, maintaining our commitment to transparency and quality assurance.
    • Bioavailable Form: NAC provides superior bioavailability compared to standard L-cysteine, with the acetyl group protecting the amino acid during digestion and enhancing absorption for maximum benefit.
    • Precise Dosing Options: Available in 200-gram and 400-gram jars, our powder format allows for accurate dosing flexibility, and customers seeking convenience can also explore our N-Acetyl L-Cysteine 500mg Capsules for standardized serving sizes.
    • Pharmaceutical-Grade Manufacturing: Produced in FDA-registered, cGMP-certified facilities using stringent quality control protocols that meet pharmaceutical manufacturing standards for anti oxidative stress supplements.

    Mechanism of Action

    • Glutathione Precursor: NAC provides the rate-limiting amino acid cysteine, which your cells use to synthesize glutathione, the body's most abundant intracellular antioxidant that supports protection against oxidative stress and supports detoxification pathways.
    • Direct Free Radical Support: The sulfhydryl group in NAC supports the body's natural antioxidant defenses against reactive oxygen species and nitrogen radicals, offering antioxidant support while your cells build up their glutathione reserves.
    • Mucolytic Action: NAC breaks disulfide bonds in mucus proteins, reducing viscosity and helping clear respiratory secretions, which supports healthy lung health support supplements and respiratory function.
    • Cellular Sulfur Donation: This amino acid derivative acts as a sulfur donor for various metabolic processes, supporting protein synthesis and maintaining the structural integrity of tissues through cysteine incorporation into proteins.

    Overview of the Science

    N-Acetyl L-Cysteine demonstrates mucolytic properties by disrupting disulfide bonds in mucus proteins, helping thin respiratory secretions and support healthy lung function. The compound crosses cell membranes more effectively than standard L-cysteine due to its acetyl group, which enhances bioavailability and tissue penetration. Research indicates that NAC supports liver detoxification pathways by serving as a precursor to glutathione, particularly important during periods of oxidative challenge. Clinical studies have also examined its role in supporting healthy inflammatory responses in respiratory tissues, making it a valuable addition to comprehensive lung health protocols.

    The amino acid's sulfur-containing structure allows it to directly interact with oxidizing molecules, providing antioxidant support beyond its role as a glutathione precursor. This dual mechanism of action supports both acute and long-term cellular protection strategies. NAC also influences cysteine availability for protein synthesis, supporting the maintenance of structural proteins that require sulfur-containing amino acids for proper folding and function.

    Ingredients

    N-Acetyl L-Cysteine:

    • 500mg per serving
    • Pharmaceutical-grade amino acid derivative
    • Superior bioavailability compared to standard L-cysteine

    The acetyl group attached to the cysteine molecule protects it from degradation in the digestive tract, allowing for enhanced absorption and tissue uptake. This molecular modification ensures that more of the active compound reaches your cells intact, maximizing the therapeutic potential for cellular health supplements applications. Our pharmaceutical-grade NAC undergoes precise manufacturing processes to maintain molecular stability and purity, delivering consistent potency in every serving for optimal liver support supplements benefits.

  • Lab Testing Results / Certificate of Analysis (COA)

  • Frequently asked questions

    1. Can I take NAC with other Nootropics Depot supplements?

      Yes, NAC can be safely combined with most other Nootropics Depot supplements. Our N-Acetyl L-Cysteine works well alongside antioxidant supplements like Vitamin C or CoQ10, and pairs nicely with immune support products. We recommend taking NAC on an empty stomach for best absorption, so timing may need adjustment if combining with supplements that require food.

    2. How much NAC powder should I take daily?

      Our NAC powder provides 600mg per 1/4 teaspoon, which is an effective daily serving for most people. Take once daily on an empty stomach for optimal absorption.

    3. Should I take NAC on an empty stomach?

      Yes, our N-Acetyl L-Cysteine is best taken on an empty stomach for optimal absorption. We recommend taking it first thing in the morning for better uptake across cell membranes.

    4. How does NAC boost glutathione levels?

      NAC provides cysteine, the rate-limiting amino acid your body needs to synthesize glutathione. The acetyl group enhances cellular uptake compared to regular cysteine, allowing more efficient transport across cell membranes where glutathione production occurs. Our high-purity NAC powder supports your body's natural glutathione synthesis pathways, particularly when glutathione stores become depleted during oxidative stress.

    5. Why is Nootropics Depot's NAC more stable than others?

      Our NAC powder undergoes specialized storage and handling protocols that protect it from moisture and heat degradation. We store NAC in climate-controlled environments and use proper packaging techniques to maintain its stability, while many other manufacturers overlook these critical factors that cause N-Acetyl L-Cysteine to break down and lose potency over time.

    6. What is NAC supplement?

      N-Acetyl L-Cysteine (NAC) is a stable, bioavailable form of the amino acid L-cysteine that serves as a powerful antioxidant precursor. NAC supports immune function by helping replenish glutathione levels, your body's master antioxidant, while also supporting healthy respiratory function and inflammatory responses. Our NAC powder provides high-purity N-Acetyl L-Cysteine that crosses cell membranes more effectively than standard L-cysteine for cellular protection and detoxification support.

    7. When to take NAC supplement?

      Our N-Acetyl L-Cysteine is best taken on an empty stomach for optimal absorption, as food can interfere with uptake. You can take it at any time of day that works for your routine, though many people prefer morning dosing.

    8. What are the benefits of N-Acetyl L-Cysteine?

      N-Acetyl L-Cysteine supports immune function, helps replenish glutathione levels (your body's master antioxidant), and promotes healthy inflammatory responses. NAC also supports respiratory function by helping thin mucus secretions and may assist liver detoxification pathways during periods of oxidative stress. Our NAC powder delivers high bioavailability due to its acetyl group, which enhances cellular uptake compared to standard L-cysteine.

Trust Through Transparency

Your health matters, which is why we only use the best 3rd party ISO accredited labs and cGMP certified and FDA registered facilities right here in the USA

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N-Acetyl L-Cysteine Powder | NAC

N-Acetyl L-Cysteine Powder | NAC

$27.99 - $45.99