About Nicotinamide Mononucleotide (NMN) Enteric Coated Tablets

Nicotinamide Mononucleotide (NMN) is a potent NAD+ (Nicotinamide adenine dinucleotide) precursor that supports cellular health and mitochondrial function. Our enteric coated tablets protect NMN from stomach acid degradation, ensuring optimal absorption through the small intestine's specialized Slc12a8 transporter. This targeted delivery method maximizes bioavailability and supports healthy NAD+ levels throughout your body's vital organs.

Our NMN Story

We spotted a critical gap in the NMN market: most supplements were failing to deliver their full potential due to poor absorption. Standard NMN tablets dissolve in the stomach's acidic environment, where the compound degrades before reaching the small intestine where absorption actually occurs. This fundamental bioavailability problem meant customers weren't getting the NAD+ support they expected from their supplement.

Our solution was developing an enteric coating specifically formulated to protect NMN during its journey through the digestive system. This pharmaceutical-grade coating remains intact in stomach acid but dissolves precisely when the tablet reaches the small intestine's alkaline environment. By ensuring safe passage to the Slc12a8 transporter, our enteric coating delivers significantly higher concentrations of active NMN for longevity and metabolism support than standard formulations.

Benefits

• Enhances Metabolic Function: NMN supports glucose tolerance and insulin production, particularly under high-fat diet conditions by restoring NAD+ levels and promoting balanced sensitivity in fatty tissues.
• Enhances Mitochondrial Function: NMN boosts NAD+ concentrations and helps maintain mitochondrial performance across multiple organs including the liver, muscle, kidneys, pancreas, blood vessels, and eyes.
• Promotes Healthy Aging: Regular NMN supplementation compensates for the natural decline in cellular energy production that occurs with aging, with research showing benefits in older populations through enhanced cell proliferation.
• Contributes To Overall Heart Health: NMN supports NAD+ production in blood vessels and helps balance inflammation levels caused by free radical damage, promoting healthy circulation and vascular function.

The enteric coating technology protects NMN from stomach acid degradation and delivers it intact to the small intestines where it absorbs through its dedicated Slc12a8 transporter. This absorption pathway means NMN faces no competition from other compounds, resulting in superior uptake compared to standard formulations.

Quality and Standardization

• Enteric Coating Technology: Our specialized enteric coating prevents tablet disintegration in the stomach's acidic environment, ensuring NMN reaches the small intestines intact where it absorbs through the dedicated Slc12a8 transporter.
• Third-Party Testing: Each batch undergoes rigorous identity and purity verification through independent laboratory analysis to confirm exact NMN content and absence of contaminants.
• Optimal Bioavailability: Unlike other compounds that compete for shared transporters, NMN utilizes its own exclusive absorption pathway in the small intestines, maximizing uptake efficiency when protected by our enteric coating.
• Pharmaceutical-Grade Manufacturing: We source high-purity NMN and manufacture tablets under strict quality control protocols to ensure consistent potency and cellular health support across every dose.

Mechanism of Action

• Slc12a8 Transporter Pathway: NMN absorbs exclusively through the small intestine via the specialized Slc12a8 transporter, which provides a dedicated absorption pathway without competition from other compounds that share generic transporters.
• NAD+ Biosynthesis: Once absorbed, NMN directly converts to NAD+ through the salvage pathway, bypassing the rate-limiting steps that affect other NAD+ precursors and providing rapid restoration of cellular health at the mitochondrial level.
• Organ-Specific Distribution: NMN supplementation promotes NAD+ production across multiple organ systems including liver, muscle, kidneys, pancreas, and blood vessels, supporting comprehensive physiological function through enhanced longevity pathways.
• Metabolic Restoration: By replenishing declining NAD+ pools, NMN activates sirtuins and PARPs (DNA repair enzymes), which restore glucose tolerance and insulin sensitivity while supporting the body's natural response to metabolic stress.

Overview of the Science

Research demonstrates that NMN supplementation helps maintain NAD+ concentrations across multiple organ systems, supporting cellular function throughout the aging process [1]. Long-term studies in animal models reveal that NMN administration promotes glucose tolerance and insulin production, particularly under high-fat diet conditions. These metabolic benefits stem from NMN's ability to restore sufficient NAD+ production while supporting balanced inflammatory responses in fatty tissue. The compound's effects extend beyond basic metabolism, influencing cellular processes across the liver, muscle, kidneys, pancreas, blood vessels, and eyes.

Clinical investigations show that NMN's benefits appear most pronounced in older subjects, where age-related NAD+ decline creates opportunities for supplementation to restore cellular function. The research indicates that regular NMN intake supports cell proliferation and mitochondrial energy production, addressing the fundamental mechanisms underlying age-associated decline. These findings suggest that NMN supplementation may offer particular value for individuals seeking to support their cellular health as part of comprehensive longevity protocols.

[1] Mills KF, Yoshida S, Stein LR, et al. Cell Metabolism. 2016;24(6):795-806.

Ingredients

Nicotinamide Mononucleotide (NMN):

• 125mg per enteric coated tablet
• β-form crystalline structure for enhanced stability
• Protected from gastric acid degradation

Our NMN tablets utilize pharmaceutical-grade β-nicotinamide mononucleotide in its most stable crystalline form. The enteric coating technology ensures protection from stomach acid while delivering the compound intact to the small intestine, where specialized transporters facilitate optimal uptake. This formulation approach maximizes bioavailability compared to standard cellular health supplements that lack protective coating technology.