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Dose
125mg (One Tablet)
Dose Timing
Morning
How to Take
With Or Without Food
Dose Frequency
1-2 Times Daily
Time to notice full effects: 2-3 Weeks (With Acute Effects)
Metabolism
Mitochondria
Longevity
Cardiovascular
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Nicotinamide Mononucleotide (NMN) is a derivative of Niacin. Niacin is a form of vitamin B3 and is also known as nicotinic acid. Vitamin B3 is one of 13 essential vitamins our bodies need. Nicotinamide Mononucleotide is known as a precursor to NAD+ (Nicotinamide adenine dinucleotide), NAD+ is a coenzyme in all living cells and plays a role in processes such as metabolism to DNA repair. Nicotinamide Mononucleotide is a critical component in the production of NAD+ because the body converts Nicotinamide Mononucleotide into NAD+. Since NAD+ levels are critical for keeping the mitochondria working at optimal levels, Nicotinamide Mononucleotide is viewed as one of the more important compounds in regards to maintaining cellular health.
There are a few differences between Nicotinamide Mononucleotide vs Nicotinamide Riboside. Nicotinamide Mononucleotide is not considered a form of vitamin B3 while Nicotinamide Riboside has shown to be a proven form of vitamin B3. In terms of structure, Nicotinamide Mononucleotide molecules are larger and weigh more than Nicotinamide riboside molecules. Nicotinamide Mononucleotide has shown positive effects on NAD+ levels in animal models and is currently being tested in humans.
Our cells’ ability to produce energy declines as we age. Although science isn’t sure why this happens, research has discovered that NAD+ levels decrease as we age which leads to the belief that lowered NAD+ levels are responsible for lower energy levels and that using a Nicotinamide Mononucleotide supplement may compensate for the loss of energy production.
Scientists ran several trials on the effects on mice after administering a Nicotinamide Mononucleotide supplement. Interestingly enough, energy promoting benefits were found exclusively in older mice. Research has found that Nicotinamide Mononucleotide benefits may help support overall cell proliferation. This leads to the belief that these cellular benefits are related to high NAD+ levels that maintain production of energy in the cell’s mitochondria.
Studies further found that regular NMN supplementation elevates NAD+ concentrations in the body, thus providing a readily available supply of NAD+ to be used. This research also demonstrated that NMN supplementation promotes the creation of NAD+ across organs such as the liver, muscle, kidneys, pancreas, blood vessels, and eyes. However, Nicotinamide Mononucleotide benefits go beyond increased NAD+ production. Some studies demonstrated that NMN may raise glucose tolerance and elevate insulin production under high fat diet conditions. This is believed to be the result of restoring sufficient NAD+ production and by balancing inflammation and stress caused by free radical damage. These studies found that NMN supports balanced inflammation levels within fatty tissue and improves sensitivity.
NMN has some very interesting absorption mechanisms, which leaves a lot of room for improving NMN bioavailability. In fact, there are even some rumors that NMN itself does not absorb at all, and has to be converted into Nicotinamide Riboside (NR) first. However, this rumor is false. NMN can absorb incredibly well by itself, but with a few caveats! For starters, NMN does not absorb in the stomach at all, and the compound is somewhat sensitive to the acidic environment in our stomach. NMN instead absorbs very rapidly and easily in the small intestines. This is due to the fact that NMN has its own specific transporter in the small intestines called Slc12a8.
Most compounds, including NMN, get absorbed through either passive diffusion mechanisms or active transporters. However, most of these active transporters are shared with other compounds, and can facilitate the transport of various different things. These different compounds then compete with each other for absorption through those transporters. For example, beta-alanine and taurine both share the same active transporter, and thus the two can compete for absorption. This is where NMN has a clear advantage! Since NMN has its own specific transporter, and if NMN makes it to the small intestines intact, it will be absorbed very efficiently. This is because there are no other compounds that can compete with NMN absorption through the Slc12a8 transporter. The trick here is getting NMN into the small intestines intact, and this is where an enteric coating comes in and helps to enhance overall NMN bioavailability!
Since NMN only absorbs in the small intestines through the Slc12a8 transporter, the best NMN bioavailability can be achieved by ensuring safe passage through the stomach and into the small intestines. NMN may degrade in the stomach due to the acidic conditions, thus we decided to put an enteric coating on our NMN tablets. This enteric coating prevents disintegration of the NMN tablet in the stomach and instead delays tablet disintegration until the NMN tablet reaches the small intestines. By utilizing the enteric coating, we can ensure the highest possible concentration of NMN in the small intestines, thus optimizing NMN bioavailability.
NMN + NA-R-ALA for metabolic function: This combination may help support metabolic function and may help promote energy levels.*
NMN + EZ Mega 3 Fish Oil for oxidation benefits: Combine these two for well rounded support for oxidation levels.*
NMN + Cognizin Citicoline for cognitive function benefits: These two together make for a simple but potent stack for promoting memory and overall cognition. *
As a dietary supplement, take 1 enteric coated Nicotinamide Mononucleotide tablet 1-2 times daily.
To gain more insight, see the Nicotinamide Mononucleotide tablet reviews and experiences below.
Nootropics Depot offers 30ct and 60ct jars of high quality Nicotinamide Mononucleotide enteric coated tablets. Nootropics Depot’s Nicotinamide Mononucleotide has been lab-tested and verified for both product purity and identity.
| *Attention: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. |
I prematurely judged this one honestly. Everyone had amazing things to say concerning energy on NMN, but it made me tired. I saw that it required CoQSol from ND to work right. I just tossed to the side for months. But after reading into it, it made a lot of sense why the two help each other. So I bought CoqSol from ND. This gives me a very natural energy, like it’s not stimulating. I just feel very alert and all my fatigue is gone.
Tough to tell with these sorts of supplements whether they are working, since there is not an acute cognitive effect. But my alcohol tolerance is substantially higher, and I get zero hangovers the next day even when I haven’t been hydrating as much. So I fee rather confident that it is doing something.
This is the best nmn I have ever tried. The effects are very consistent. It gives me a good clean stimulation without speeding time up too much.
I have been a fan of tru niagen and following the research for a few years now so was excited to try this .I have been taking it with a regular over the counter type “beauty booster” which has a few trace B via takin groups.I don’t get the lift and sustained energy that I did with NR . However for me in Australia NMN is a quarter of the price.I am considering buying this again and supplementing with NR on the occasion to see if I get a closer result on a budget.I will say my skin feels plump let and hydrated which wasn’t noticeable when I was taking the beauty supplement alone.
As a longtime experimenter with a host of supplements, I was surprised by NMN. I stuck with the recommended dose of 125mg and within a couple of days noticed an absence of fatigue and increasing mental sharpness--and that quality has persisted a month into daily usage so far. I suggest using this as a good foundational supplement akin to magnesium.
After my friend told me that this supplement is the top antiaging supplement we know of so far, I had to try it so I bought from the same brand as him and, surprise surprise, my biological age now reads 16 while I am 25. The only other things I’m doing besifes taking NMN are exercise and eating healthy (but not fasting). I am very surprised by the results. Will definitely recommend.
This has surely been a saving grace!
I have been taking NMN for the past 5 years and just recently switched to the one the Nootropicsdepot guys sell because it’s cheaper and I must say I am not disappointed in the slightest. The efficacy is the same as what I got before and I get results. I’m a heavy smoker (6 cigs on a good day, more on a bad day) and even though I’m 25, people think I’m 14.-16. It freaks me out a bit because it seems as I froze in time ( I don’t seem to age or anything) but I think it must be because I exercise every day for 20 minutes in the morning, I take 500 mg resveratrol, I fast 16-18 hours a day, I take metformin at night (you don’t need a prescription in my country) but most importantly, because of the NMN (I take 625 mg because I weigh 60 kg). I wonder what the next years will bring and, who knows? Maybe I get to live 150!
Definitely works. Considering cutting out some other supplements as all together is too much stimulation. This is the one that I will not live without.
I have had severe joint pain for 15 yrs. No biologicis have worked. This product is helping give me some relief with the swelling etc.
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