Piperine Research Snapshot

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Let us take the guess work out of analyzing the research, so you can understand the science behind Berberine Phytosome's potential benefits.

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Piperine Primary Benefits

Metabolism

Neuroprotection

Gut Health

Oxidation

The studies highlighted below are based on general research of Piperine, not specifically on Nootropics Depot's product. Piperine can come in many forms and standardizations, and not all of them have the same efficacy. This research snapshot is intended to highlight the current state of the science regarding Piperine, and should not be construed as direct evidence for the clinical efficacy of any one specific product.

Does Piperine Extract Support Metabolic Health?

Summary

These studies suggest that Piperine Extract (Piper nigrum) supports metabolic health by improving blood lipid profiles, reducing cholesterol levels, enhancing antioxidant and anti-inflammatory properties, improving insulin and leptin sensitivity, and regulating obesity.

We've highlighted the some of the relevant studies below.

Cafeteria Diet-Induced Metabolic and Cardiovascular Changes in Rats: The Role of Piper nigrum Leaf Extract

Piper nigrum leaf extract may prevent weight gain and possess cardioprotective activity with a strong antioxidant activity.

Evidence-based Complementary and Alternative Medicine : eCAM Dorothee | L. E. Mballa et al. | 1 citations | 2021

Randomized Controlled Trial

Animal Trial

Rigorous Journal

Efficacy and Safety of Berberine Alone: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Berberine may support weight management, promote healthy lipid levels, aid in improving insulin sensitivity, and contribute to overall metabolic health.

Frontiers in Pharmacology | Yulan Ye, Xiu-fen Liu, Ning-hua Wu, Yanqi Han, Jiawen Wang, Yuandong Yu, Qingjie Chen | 39 citations | 2021

Meta Analysis

Efficacy of berberine in patients.

Berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism.

Metabolism: clinical and experimental | Jun-yi Yin, Huili Xing, Jianping Ye | 634 citations | 2008

Randomized Controlled Trial

Highly Cited

Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus

Berberine may offer beneficial effects for metabolic health and blood sugar management, with potential mechanisms of action and interactions to consider.

Revista Brasileira de Farmacognosia | Aram Khashayar, Z. Bahari, Moradipour Elliyeh, Maedeh Ghasemi | 12 citations | 2021

Systematic Review

Can Berberine Promote Microbiome Health?

Summary

These studies suggest berberine can promote microbiome health by modulating gut microbiota composition, reducing inflammation, and improving metabolic conditions.

We've highlighted the some of the relevant studies below.

Gut microbiome-related effects of berberine and probiotics (the PREMOTE study)

Berberine and probiotics combined significantly lower blood glucose levels, with a human gut microbiome-related mechanism underlying this effect.

Nature Communications | Yifei Zhang, Yanyun Gu, Huahui Ren, Shujie Wang, Huanzi Zhong, Xinjie Zhao, +27 others | 181 citations | 2020

Randomized Controlled Trial

Large Human Trial

Highly Cited

Effects of Berberine on the Gastrointestinal Microbiota

Berberine can help regulate the gastrointestinal microbiota, potentially contributing to its lipid-lowering and insulin resistance effects.

Frontiers in Cellular and Infection Microbiology | Lichao Zhang, Xiaoying Wu, Ruibing Yang, Fang Chen, Y. Liao, Zifeng Zhu, +3 others | 32 citations | 2021

Systematic Review

Berberine Pharmacology and the Gut Microbiota: A Hidden Therapeutic Link

Berberine's diverse benefits are associated with its ability to support gut microbiota balance under various conditions.

Pharmacological research | S. Habtemariam | 162 citations | 2020

Rigorous Journal

Highly Cited

Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice.

Berberine and metformin effectively reduce body weight, blood glucose levels, and intestinal inflammation in db/db mice, potentially improving diabetic complications.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Wang Zhang, Jihao Xu, Tao Yu, Qi-Kui Chen | 146 Citations | 2019

Non Randomized Controlled Trial

Animal Trial

Rigorous Journal

Highly Cited

Does Berberine Enhance Cognitive Performance?

Summary

These studies suggest that Berberine enhances cognitive performance across various animal models, including those with cognitive impairments related to vascular issues, blood sugar imbalances, and ethanol exposure.

We've highlighted the some of the relevant studies below.

Neuroprotective Effect and Possible Mechanisms of Berberine: A Systematic Review and Meta-Analysis of Animal Studies

Berberine supplementation can lower blood glucose levels and improve learning and memory, potentially through regulating glucose and lipid metabolism, improving insulin resistance, and reducing oxidative stress and inflammation.

Frontiers in Pharmacology | Yanwei Hao, Jia-Xin Li, Shengnan Yue, Shaofeng Wang, Shuangyuan Hu, Bin Li | 4 citations | 2022

Meta Analysis

Berberine for supporting cognitive health in individuals: A systematic review.

Berberine may support cognitive health and help protect the brain by addressing risk factors like metabolic dysfunction and promoting overall cardiovascular, kidney, and liver health.

Journal of Integrative Medicine | N. Shinjyo, J. Parkinson, Jimmy D Bell, T. Katsuno, Annie Bligh | 27 citations | 2020

Systematic Review

Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model.

Berberine improves memory in mice with cognitive impairments by promoting autophagic clearance and reducing the production of amyloid proteins.

Experimental Gerontology | Min Huang, Xin Jiang, Yubin Liang, Qiong Liu, Siyan Chen, Yi Guo | 116 citations | 2017

Non Randomized Controlled Trial

Animal Trial

Highly Cited

Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats

Berberine significantly improves cognitive deficits and insulin resistance in naturally aging rats, potentially due to its ability to activate the AMPK/SIRT1/PGC-1 pathway in skeletal muscle.

The Journal Of Nutrition, Health & Aging | Yang Yu, Yali Zhao, Fei Teng, Jing Li, Y. Guan, J. Xu, X. Lv, F. Guan, Ming Zhang, Li Chen | 69 citations | 2018

Non Randomized Controlled Trial

Animal Trial

Rigorous Journal

Can Berberine Help Support Cardiovascular Function?

Summary

These studies suggest berberine can support cardiovascular function by improving lipid profiles, reducing myocardial injury, and enhancing cardiac function.

We've highlighted the some of the relevant studies below.

Effect of Berberine on Cardiovascular Risk Factors: A Mechanistic Randomized Controlled Trial

Berberine effectively lowers cholesterol and may increase testosterone in men with hyperlipidemia, suggesting sex-specific effects.

Nutrients | Jie V. Zhao et al. | 18 citations | 2021

Randomized Controlled Trial

Very Rigorous Journal

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.

Berberine therapy reduces myocardial injury in postoperative patients by reducing autophagy and apoptosis through the AMPK/mTOR pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Yao Qing et al. | 28 citations | 2018

Randomized Controlled Trial

Very Rigorous Journal

The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis

Berberine supplementation significantly improves lipid profile, fasting blood glucose balance, obesity parameters, and systolic blood pressure in adults.

Frontiers in Nutrition | M. Zamani et al. | 4 citations | 2022

Meta Analysis

Berberine in Cardiovascular and Metabolic Functions: From Mechanisms to Therapeutics

Berberine shows promising therapeutic potential in treating cardiovascular and metabolic functions, with recent discoveries identifying novel molecular targets and supporting its therapeutic potential.

Theranostics | Xiaojun Feng et al. | 212 citations | 2019

Rigorous Journal

Highly Cited

Shop Our Berberine Products

Berberine Phytosome

More Balanced Full Spectrum

Sold out

Berberine + Silymarin

Highest Eurycomanone Content

Sold out

Berbelean

Ease Of Custom Dosing

Sold out

Buying supplements can be confusing, but it doesn't have to be.

Let us take the guess work out of analyzing the research, so you can be sure the benefits from the products you take are backed by valid science.

LEARN MORE BELOW

Berberine Primary Benefits

Metabolism

Gut Health

Cognition

Cardiovascular

The studies highlighted below are based on general research of Berberine, not specifically on Nootropics Depot's product. Berberine can come in many forms and standardizations, and not all of them have the same efficacy. This research snapshot is intended to highlight the current state of the science regarding Berberine, and should not be construed as direct evidence for the clinical efficacy of any one specific product.

Does Berberine Phytosome Support Lipid Metabolism?

Summary

These studies suggest that Berberine Phytosome supports lipid metabolism through various mechanisms, including improving lipid profiles, promoting fatty acid oxidation, and enhancing fecal lipid excretion.

We've highlighted the 4 most relevant studies below.

Tap Below To See Each Study

Berberine On The Glycemic Profile

Berberine phospholipid exerts a positive effect on the glycemic profile of overweight subjects.

Oral supplementation of Berberine PhytosomeTM (550 mg/day) significantly improves glycemia, cholesterol, triglycerides, insulin, ApoB/ApoA, and visceral adipose tissue in overweight individuals with impaired fasting blood glucose.

European review for medical and pharmacological sciences | M. Rondanelli, C. Gasparri, G. Petrangolini, P. Allegrini, D. Avenoso + 8 others | 0 citations | 2023

Randomized Controlled Trial

Efficacy And Safety Of Berberine Alone

Efficacy and Safety of Berberine Alone: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Berberine may support weight management, promote healthy lipid levels, aid in improving insulin sensitivity, and contribute to overall metabolic health.

Frontiers in Pharmacology | Yulan Ye, Xiu-fen Liu, Ning-hua Wu, Yanqi Han, Jiawen Wang, Yuandong Yu, Qingjie Chen | 39 citations | 2021

Meta Analysis

Efficacy Of Berberine In Patients

Efficacy of berberine in patients.

Berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism.

Metabolism: clinical and experimental | Jun-yi Yin, Huili Xing, Jianping Ye | 634 citations | 2008

Randomized Controlled Trial

Highly Cited

Therapeutic Effects Of Berberine In Metabolic Functions

Therapeutic Effects of Berberine in Metabolic Diseases and Diabetes Mellitus

Berberine may offer beneficial effects for metabolic health and blood sugar management, with potential mechanisms of action and interactions to consider.

Revista Brasileira de Farmacognosia | Aram Khashayar, Z. Bahari, Moradipour Elliyeh, Maedeh Ghasemi | 12 citations | 2021

Systematic Review

Can Berberine Promote Microbiome Health?

Summary

These studies suggest berberine can promote microbiome health by modulating gut microbiota composition, reducing inflammation, and improving metabolic conditions.

We've highlighted the 4 most relevant studies below.

Tap Below To See Each Study

Gut Microbiome-Related Effects Of Berberine And Probiotics

Gut microbiome-related effects of berberine and probiotics (the PREMOTE study)

Berberine and probiotics combined significantly lower blood glucose levels, with a human gut microbiome-related mechanism underlying this effect.

Nature Communications | Yifei Zhang, Yanyun Gu, Huahui Ren, Shujie Wang, Huanzi Zhong, Xinjie Zhao, +27 others | 181 citations | 2020

Randomized Controlled Trial

Large Human Trial

Highly Cited

Effects Of Berberine On The Gastrointestinal Microbiota

Effects of Berberine on the Gastrointestinal Microbiota

Berberine can help regulate the gastrointestinal microbiota, potentially contributing to its lipid-lowering and insulin resistance effects.

Frontiers in Cellular and Infection Microbiology | Lichao Zhang, Xiaoying Wu, Ruibing Yang, Fang Chen, Y. Liao, Zifeng Zhu, +3 others | 32 citations | 2021

Systematic Review

Berberine Pharmacology And The Gut Microbiota: A Hidden Therapeutic Link

Berberine Pharmacology and the Gut Microbiota: A Hidden Therapeutic Link

Berberine's diverse benefits are associated with its ability to support gut microbiota balance under various conditions.

Pharmacological research | S. Habtemariam | 162 citations | 2020

Rigorous Journal

Highly Cited

Effects Of Berberine And Metformin

Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice.

Berberine and metformin effectively reduce body weight, blood glucose levels, and intestinal inflammation in db/db mice, potentially improving diabetic complications.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Wang Zhang, Jihao Xu, Tao Yu, Qi-Kui Chen | 146 Citations | 2019

Non Randomized Controlled Trial

Animal Trial

Rigorous Journal

Highly Cited

Does Berberine Enhance Cognitive Performance?

Summary

We've highlighted the 4 most relevant studies below.

Tap Below To See Each Study

Neuroprotective Effect And Possible Mechanisms Of Berberine

Neuroprotective Effect and Possible Mechanisms of Berberine: A Systematic Review and Meta-Analysis of Animal Studies

Berberine supplementation can lower blood glucose levels and improve learning and memory, potentially through regulating glucose and lipid metabolism, improving insulin resistance, and reducing oxidative stress and inflammation.

Frontiers in Pharmacology | Yanwei Hao, Jia-Xin Li, Shengnan Yue, Shaofeng Wang, Shuangyuan Hu, Bin Li | 4 citations | 2022

Meta Analysis

Berberine For Supporting Cognitive Health

Berberine for supporting cognitive health in individuals: A systematic review.

Berberine may support cognitive health and help protect the brain by addressing risk factors like metabolic function and promoting overall cardiovascular, kidney, and liver health.

Journal of Integrative Medicine | N. Shinjyo, J. Parkinson, Jimmy D Bell, T. Katsuno, Annie Bligh | 27 citations | 2020

Systematic Review

Berberine Improves Cognitive Impairment

Berberine improves cognitive impairment by promoting autophagic clearance and inhibiting production of β-amyloid in APP/tau/PS1 mouse model.

Berberine improves memory in mice with cognitive impairments by promoting autophagic clearance and reducing the production of amyloid proteins.

Experimental Gerontology | Min Huang, Xin Jiang, Yubin Liang, Qiong Liu, Siyan Chen, Yi Guo | 116 citations | 2017

Non Randomized Controlled Trial

Animal Trial

Highly Cited

Berberine Improves Cognitive Deficiency and Muscular Function

Berberine Improves Cognitive Deficiency and Muscular Dysfunction via Activation of the AMPK/SIRT1/PGC-1a Pathway in Skeletal Muscle from Naturally Aging Rats

Berberine significantly improves cognitive deficits and insulin resistance in naturally aging rats, potentially due to its ability to activate the AMPK/SIRT1/PGC-1 pathway in skeletal muscle.

The Journal Of Nutrition, Health & Aging | Yang Yu, Yali Zhao, Fei Teng, Jing Li, Y. Guan, J. Xu, X. Lv, F. Guan, Ming Zhang, Li Chen | 69 citations | 2018

Non Randomized Controlled Trial

Animal Trial

Rigorous Journal

Can Berberine Help Support Cardiovascular Function?

Summary

These studies suggest berberine can support cardiovascular function by improving lipid profiles, reducing myocardial injury, and enhancing cardiac function.

We've highlighted the 4 most relevant studies below.

Tap Below To See Each Study

Effect Of Berberine On Cardiovascular Risk Factors

Effect of Berberine on Cardiovascular Risk Factors: A Mechanistic Randomized Controlled Trial

Berberine effectively lowers cholesterol and may increase testosterone in men with hyperlipidemia, suggesting sex-specific effects.

Nutrients | Jie V. Zhao et al. | 18 citations | 2021

Randomized Controlled Trial

Very Rigorous Journal

Berberine Promoted Myocardial Protection

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy.

Berberine therapy reduces myocardial injury in postoperative patients by reducing autophagy and apoptosis through the AMPK/mTOR pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie | Yao Qing et al. | 28 citations | 2018

Randomized Controlled Trial

Very Rigorous Journal

The Effects Of Berberine Supplementation On Cardiovascular Risk Factors

The effects of berberine supplementation on cardiovascular risk factors in adults: A systematic review and dose-response meta-analysis

Berberine supplementation significantly improves lipid profile, fasting blood glucose balance, obesity parameters, and systolic blood pressure in adults.

Frontiers in Nutrition | M. Zamani et al. | 4 citations | 2022

Meta Analysis

Berberine in Cardiovascular and Metabolic Functions

Berberine in Cardiovascular and Metabolic Functions: From Mechanisms to Therapeutics

Berberine shows promising therapeutic potential in treating cardiovascular and metabolic functions, with recent discoveries identifying novel molecular targets and supporting its therapeutic potential.

Theranostics | Xiaojun Feng et al. | 212 citations | 2019

Rigorous Journal

Highly Cited

Shop Our Berberine Products

Berberine Phytosome

More Full Spectrum

Sold out

Berberine + Silymarin

Highest Erycomanone

Sold out

Berbelean Capsules

Easier Custom Dosing

Sold out