Buying supplements can be confusing, but it doesn't have to be.
Let us take the guess work out of analyzing the research, so you can understand the science behind Berberine Phytosome's potential benefits.
LEARN MORE BELOW
Piperine Primary Benefits
Metabolism
Neuroprotection
Gut Health
Oxidation
The studies highlighted below are based on general research of Piperine, not specifically on Nootropics Depot's product. Piperine can come in many forms and standardizations, and not all of them have the same efficacy. This research snapshot is intended to highlight the current state of the science regarding Piperine, and should not be construed as direct evidence for the clinical efficacy of any one specific product.
Does Piperine Extract Support Metabolic Health?
Summary
These studies suggest that Piperine Extract (Piper nigrum) supports metabolic health by improving blood lipid profiles, reducing cholesterol levels, enhancing antioxidant and anti-inflammatory properties, improving insulin and leptin sensitivity, and regulating obesity.
We've highlighted the some of the relevant studies below.
Cafeteria Diet-Induced Metabolic and Cardiovascular Changes in Rats: The Role of Piper nigrum Leaf Extract
Piper nigrum leaf extract may prevent weight gain and possess cardioprotective activity with a strong antioxidant activity.
Evidence-based Complementary and Alternative Medicine : eCAM Dorothee | L. E. Mballa et al. | 1 citations | 2021
Randomized Controlled Trial
Animal Trial
Rigorous Journal
Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications
Piperine, the active ingredient in black pepper, is linked to improving blood lipid profiles, reducing cholesterol levels, and enhancing antioxidant and anti-inflammatory properties in overweight individuals.
Molecules | P. Dludla et al. | 0 citations | 2023
Systematic Review
Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats.
Piperine supplementation at a dose of 40mg/kgb.wt significantly reversed HFD-induced alterations in rats, improving insulin and leptin sensitivity, ultimately regulating weight.
Chemico-biological Interactions | P. Brahmanaidu et al. | 60 citations | 2014
Non Randomized Controlled Trial
Animal Trial
In Vivo Experiment
Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis.
Curcuminoid-piperine combination significantly improves oxidative and inflammatory status in patients with metabolic syndrome.
Clinical nutrition | Y. Panahi et al. | 306 citations | 2015
Rigorous Journal
Highly Cited
Meta Analysis
Does Piperine Extract Enhance Neuroprotection?
Summary
We've highlighted the some of the relevant studies below.
Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit.
Piperine significantly improved memory impairment and neurodegeneration in hippocampus in an animal model.
Food and chemical toxicology | Pennapa Chonpathompikunlert et al. | 234 citations | 2010
Non Randomized Controlled Trial
Animal Trial
Highly Cited
Black Pepper (Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent
Piperine extract (black pepper) exhibits neuroprotection by decreasing oxidative stress, restoring mitochondrial membrane potential, and showing potential anti-glycation and anti-AChE activities.
Antioxidants | Himadri Sharma et al. | 1 citations | 2023
In Vitro Trial
Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats.
Piperine extract (Piper nigrum) alleviated neurological deficits and prevented ischemia-induced cellular damage in a rat model of cerebral ischemia.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association | Shiyao Hua et al. | 19 citations | 2019
Non Randomized Controlled Trial
Animal Trial
In Vivo Trial
Amide alkaloids characterization and neuroprotective properties of Piper nigrum L.: A comparative study with fruits, pericarp, stalks and leaves.
Piperine, the most abundant compound in Piper nigrum extracts, has neuroprotective activities.
Food chemistry | Lan Yu et al. | 18 Citations | 2021
In Vitro Trial
Does Piperine Extract Support Gut Health?
Summary
We've highlighted the some of the relevant studies below.
Ocimum sanctum, Zingiber officinale, and Piper nigrum extracts and their effects on gut microbiota modulations (prebiotic potential), basal inflammatory markers and lipid levels: oral supplementation study in healthy rats
Piperine extract (Piper nigrum) has prebiotic potential, as it increases levels of beneficial gut bacteria like Lactobacillus and Bifidobacterium.
Pharmaceutical Biology | N. Kondapalli et al. | 7 citations | 2022
Non Randomized Controlled Trial
Animal Trial
Piper nigrum extract attenuates food allergy by decreasing Th2 cell response and regulating the Th17/Treg balance
Piper nigrum extract (PNE) attenuates food allergy symptoms and improves the Th17/Treg balance, supporting gut health.
Phytotherapy Research | Lei Wang et al. | 6 citations | 2021
Non Randomized Controlled Trial
Animal Trial
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
Piperine enhances digestive capacity and reduces gastrointestinal food transit time by favorably stimulating digestive enzymes.
Critical Reviews in Food Science and Nutrition | K. Srinivasan et al. | 640 citations | 2007
Highly Cited
Literature Review
Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders.
Piperine extract (Piper nigrum) has spasmodic and antispasmodic effects, supporting its medicinal use in gastrointestinal motility disorders.
Journal of medicinal food | M. H. Mehmood et al. | 81 citations | 2010
Animal Trial
In Vitro Trial
Highly Cited
Does Piperine Extract (Piper nigrum) Reduce Oxidative Stress?
Summary
We've highlighted the some of the relevant studies below.
Effect of some medicinal plant extracts on the oxidative stress status.
Piper nigrum extract significantly reduced oxidative stress status and ameliorated neurodegeneration rats.
European review for medical and pharmacological sciences | K. Mahdy et al. | 65 citations | 2012
Randomized Controlled Trial
Animal Trial
Antioxidative Effects of Piperine against Cadmium-Induced Oxidative Stress in Cultured Human Peripheral Blood Lymphocytes
Piperine significantly reduces the tail moment and peroxidation of lipids against cadmium-induced oxidative stress in cultured human peripheral blood lymphocytes.
Journal of Dietary Supplements | N. Verma et al. | 15 citations | 2018
In Vitro Trial
Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters.
Piper species, including Piper nigrum, may possess an antioxidant protective role against atherogenic diet-induced oxidative stress in cardiac, hepatic, and renal tissues.
Food chemistry | G. Agbor et al. | 28 citations | 2012
Randomized Controlled Trial
Animal Trial
Black Pepper (Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent
Piperine extract (black pepper) significantly decreases oxidative stress and restores mitochondrial membrane potential in human neuroblastoma cells.
Antioxidants | Himadri Sharma et al. | 1 citations | 2023
In Vitro Trial
Shop Our Piperine Products
Piperine Capsules
Buying supplements can be confusing, but it doesn't have to be.
Let us take the guess work out of analyzing the research, so you can be sure the benefits from the products you take are backed by valid science.
LEARN MORE BELOW
Piperine Primary Benefits
Metabolism
Neuroprotection
Gut Health
Oxidation
The studies highlighted below are based on general research of Piperine, not specifically on Nootropics Depot's product. Piperine can come in many forms and standardizations, and not all of them have the same efficacy. This research snapshot is intended to highlight the current state of the science regarding Piperine, and should not be construed as direct evidence for the clinical efficacy of any one specific product.
Does Piperine Extract Support Metabolic Health?
Summary
These studies suggest that Piperine Extract (Piper nigrum) supports metabolic health by improving blood lipid profiles, reducing cholesterol levels, enhancing antioxidant and anti-inflammatory properties, improving insulin and leptin sensitivity.
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Cafeteria Diet-Induced Metabolic and Cardiovascular Changes in Rats
Cafeteria Diet-Induced Metabolic and Cardiovascular Changes in Rats: The Role of Piper nigrum Leaf Extract
Evidence-based Complementary and Alternative Medicine : eCAM Dorothee | L. E. Mballa et al. | 1 citations | 2021
Randomized Controlled Trial
Animal Trial
Rigorous Journal
Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper
Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of the Potential Benefits of Black Pepper (Piper nigrum) and Red Pepper (Capsicum annum) against Diverse Metabolic Complications
Molecules | P. Dludla et al. | 0 citations | 2023
Systematic Review
Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats.
Mitigating efficacy of piperine in the physiological derangements of high fat diet induced obesity in Sprague Dawley rats.
Chemico-biological Interactions | P. Brahmanaidu et al. | 60 citations | 2014
Non Randomized Controlled Trial
Animal Trial
In Vivo Experiment
Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome
Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis.
Clinical nutrition | Y. Panahi et al. | 306 citations | 2015
Rigorous Journal
Highly Cited
Meta Analysis
Does Piperine Extract Enhance Neuroprotection?
Summary
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit.
Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit.
Food and chemical toxicology | Pennapa Chonpathompikunlert et al. | 234 citations | 2010
Non Randomized Controlled Trial
Animal Trial
Highly Cited
Black Pepper (Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent
Black Pepper (Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent
Antioxidants | Himadri Sharma et al. | 1 citations | 2023
In Vitro Trial
Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats.
Neuroprotective Effect of Dichloromethane Extraction From Piper nigrum L. and Piper longum L. on Permanent Focal Cerebral Ischemia Injury in Rats.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association | Shiyao Hua et al. | 19 citations | 2019
Non Randomized Controlled Trial
Animal Trial
In Vivo Trial
Amide alkaloids characterization and neuroprotective properties of Piper nigrum L.: A comparative study with fruits, pericarp, stalks and leaves.
Amide alkaloids characterization and neuroprotective properties of Piper nigrum L.: A comparative study with fruits, pericarp, stalks and leaves.
Food chemistry | Lan Yu et al. | 18 Citations | 2021
In Vitro Trial
Does Piperine Extract Support Gut Health?
Summary
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Ocimum sanctum, Zingiber officinale, and Piper nigrum extracts and their effects on gut microbiota modulations (prebiotic potential), basal inflammatory markers and lipid levels: oral supplementation study in healthy rats
Ocimum sanctum, Zingiber officinale, and Piper nigrum extracts and their effects on gut microbiota modulations (prebiotic potential), basal inflammatory markers and lipid levels: oral supplementation study in healthy rats
Pharmaceutical Biology | N. Kondapalli et al. | 7 citations | 2022
Non Randomized Controlled Trial
Animal Trial
Piper nigrum extract attenuates food allergy by decreasing Th2 cell response and regulating the Th17/Treg balance
Piper nigrum extract attenuates food allergy by decreasing Th2 cell response and regulating the Th17/Treg balance
Phytotherapy Research | Lei Wang et al. | 6 citations | 2021
Non Randomized Controlled Trial
Animal Trial
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
Critical Reviews in Food Science and Nutrition | K. Srinivasan et al. | 640 citations | 2007
Literature Review
Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders.
Pharmacological basis for the medicinal use of black pepper and piperine in gastrointestinal disorders.
Journal of medicinal food | M. H. Mehmood et al. | 81 citations | 2010
Animal Trial
In Vitro Trial
Highly Cited
Does Piperine Extract (Piper nigrum) reduce oxidative stress?
Summary
We've highlighted the 4 most relevant studies below.
Tap Below To See Each Study
Effect of some medicinal plant extracts on the oxidative stress status
Effect of some medicinal plant extracts on the oxidative stress status.
European review for medical and pharmacological sciences
| K. Mahdy et al. | 65 citations | 2012
Randomized Controlled Trial
Animal Trial
Antioxidative Effects of Piperine against Cadmium-Induced Oxidative Stress in Cultured Human Peripheral Blood Lymphocytes
Antioxidative Effects of Piperine against Cadmium-Induced Oxidative Stress in Cultured Human Peripheral Blood Lymphocytes
Journal of Dietary Supplements | N. Verma et al. | 15 citations | 2018
In Vitro Trial
Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters.
Piper species protect cardiac, hepatic and renal antioxidant status of atherogenic diet fed hamsters.
Food chemistry | G. Agbor et al. | 28 citations | 2012
Randomized Controlled Trial
Animal Trial
Black Pepper (Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent
Black Pepper (Piper nigrum) Alleviates Oxidative Stress, Exerts Potential Anti-Glycation and Anti-AChE Activity: A Multitargeting Neuroprotective Agent against Neurodegenerative Diseases
Antioxidants | Himadri Sharma et al. | 1 citation | 2023
In Vitro Trial