About Pomella Capsules

Pomella is a clinically researched pomegranate extract standardized to punicalagins, the bioactive polyphenols that deliver pomegranate's powerful health benefits. The premium extract preserves the native ratio of whole pomegranate compounds, providing the potent anti oxidative stress supplements activity of several pomegranates in a concentrated 150mg dose that supports cardiovascular health and cellular function.

Our Pomella Story

Evaluating pomegranate supplements revealed a market flooded with poorly standardized extracts and juice powders that couldn't deliver consistent bioactive compounds. Most products focused on ellagic acid content, but research from Texas A&M University revealed that punicalagins, not ellagic acid, are the key to pomegranate's bioactivity. This discovery led us to partner with Verdure Sciences and their Pomella extract.

Pomella earned our selection because it's backed by over 30 clinical trials and maintains the complete profile of pomegranate polyphenols in their bioavailable forms. While competitors use generic pomegranate powders, Pomella undergoes rigorous standardization to ensure consistent punicalagin levels and optimal absorption. The extract metabolizes into beneficial compounds like urolithin A and urolithin B, supporting longevity pathways and healthy inflammatory responses throughout the body.

Benefits

• Supports Healthy Heart Function: Pomella delivers punicalagins that help maintain healthy cardiovascular markers, backed by more than 30 clinical trials on pomegranate's heart health benefits.
• Nourishes Beneficial Gut Bacteria: Punicalagins break down into urolithin compounds that feed beneficial bacteria and support healthy gut microbiome balance.
• Supports Healthy Oxidative Balance: Each capsule provides the antioxidant power of several whole pomegranates, helping protect cells from daily oxidative stress.
• Promotes Healthy Skin Appearance: Pomella's polyphenol compounds support skin health from within by supporting healthy cellular function and oxidative balance in skin tissues.

A Texas A&M University study found that Pomella's punicalagins absorb into colon cells as bioactive metabolites, while purified ellagic acid alone showed no absorption. This confirms that the complete pomegranate polyphenol profile delivers superior bioavailability and effectiveness.

Quality and Standardization

• Punicalagin Standardization: We standardize Pomella to punicalagins, the key bioactive compounds that distinguish effective pomegranate extracts from inferior products lacking proper standardization.
• Verdure Sciences Manufacturing: Pomella is produced in a botanicals-only facility certified to ISO9001:2008 and Good Manufacturing Practices, ensuring consistent potency and purity.
• Bioavailability Verification: Texas A&M University research confirmed that Pomella absorbs into colon cells as bioactive metabolites, while purified ellagic acid showed no absorption.
• Native Compound Preservation: Our extract maintains the natural ratio of whole pomegranate polyphenols rather than isolating single compounds, maximizing the cellular health supplements potential.
• Third-Party Safety Testing: Pomella undergoes extensive safety evaluations and delivers pomegranate's benefits without the added calories or sugars found in urolithin A supplements alternatives.

Mechanism of Action

• Punicalagin Hydrolysis: Punicalagins, the primary active compounds in Pomella, undergo enzymatic breakdown in the digestive tract to release ellagic acid and other metabolites that deliver the extract's therapeutic effects.
• Urolithin Metabolite Production: Gut bacteria convert punicalagins into beneficial urolithin compounds including urolithin A and B, which demonstrate enhanced bioavailability and cellular uptake compared to the parent compounds.
• Free Radical Neutralization: The polyphenolic structure of punicalagins enables direct scavenging of reactive oxygen species, protecting cellular health from oxidative damage at the molecular level.
• Vascular Endothelial Support: Pomella's bioactive metabolites help maintain healthy nitric oxide production and endothelial function, supporting optimal blood vessel flexibility and blood flow throughout the body.

Overview of the Science

Pomella pomegranate extract demonstrates superior bioavailability compared to isolated ellagic acid supplements [1]. Research shows that punicalagins are efficiently absorbed in the gastrointestinal tract and converted into bioactive metabolites, including urolithin A, urolithin B, and their glucuronide conjugates [2]. Clinical studies have found that pomegranate supplementation can significantly increase plasma levels of these beneficial compounds within hours of consumption, with peak concentrations reached between 4-12 hours post-ingestion [3]. The gut health microbiome plays a crucial role in this conversion process, as specific bacterial strains metabolize punicalagins into urolithins that support mitochondrial function and cellular health.

Multiple randomized controlled trials have demonstrated pomegranate extract's cardiovascular benefits, including support for healthy blood pressure levels already within normal range [4]. In one study, participants consuming 150mg of pomegranate extract daily for 12 weeks showed improvements in markers of endothelial function and arterial elasticity compared to placebo [5]. Additional research indicates that punicalagins help maintain healthy lipid profiles and support the body's natural inflammatory response [6]. The metabolite urolithin A has been specifically studied for its role in mitochondrial biogenesis, with trials showing enhanced cellular energy production in healthy adults following pomegranate supplementation [7].

[1] Seeram NP et al. Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. Journal of Agricultural and Food Chemistry. 2007;55(19):7732-7737.

[2] González-Sarrías A et al. Clustering according to urolithin metabotype explains the interindividual variability in the improvement of cardiovascular risk biomarkers in overweight-obese individuals consuming pomegranate: A randomized clinical trial. Molecular Nutrition & Food Research. 2017;61(5):1600830.

[3] Singh A et al. Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. European Journal of Clinical Nutrition. 2021;75(11):1697-1709.

[4] Stockton A et al. Effect of pomegranate extract on blood pressure and anthropometry in adults: a double-blind placebo-controlled randomised clinical trial. Journal of Nutritional Science. 2017;6:e39.

[5] Quirós-Fernández R et al. Supplementation with hydroxytyrosol and punicalagin improves early atherosclerosis markers involved in the asymptomatic phase of atherosclerosis in the adult population: A randomized, placebo-controlled, crossover trial. Nutrients. 2019;11:640.

[6] Sahebkar A et al. Effects of pomegranate juice on blood pressure: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research. 2017;115:149-161.

[7] Andreux PA et al. The mitochondrial unfolded protein response is activated upon exposure to the mitochondria-derived postbiotic urolithin A. Nature Metabolism. 2022;4(5):597-610.

Ingredients

Pomella® Pomegranate Extract:

• Pomegranate fruit extract (Punica granatum)
• Standardized to ≥30% punicalagins by HPLC
• 150mg per capsule

The ≥30% punicalagin standardization ensures consistent delivery of the specific polyphenolic compounds responsible for pomegranate's therapeutic effects. This high-potency standardization maintains the native ratio of pomegranate polyphenols while concentrating the bioactive punicalagins that distinguish clinical-grade extracts from generic pomegranate products. Verdure Sciences' proprietary extraction process preserves these delicate compounds at therapeutic concentrations, delivering the equivalent potency of several whole pomegranates in a single concentrated capsule for cellular health supplements.